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Objective: Assess how chemotherapy influences diaphragm mobility and diaphragm thickness. Methods: A cross-sectional observational study recruited 30 diagnosed patients meeting inclusion criteria, with ultrasonography performed before chemotherapy and after 5 weeks. Results and conclusions quantify significant decline after treatment.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/effect-of-chemotherapy-on-diaphragm-mobility-and-diaphragm-thickness-in-breast-cancer-patients-an-observational-study/639379/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/effect-of-chemotherapy-on-diaphragm-mobility-and-diaphragm-thickness-in-breast-cancer-patients-an-observational-study/639379.png","ImageObject",300,407,{"name":92,"@type":93},"Supernature","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-09","2026-10-22",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the objective of the observational study?","Question",{"text":112,"@type":113},"To determine the effect of chemotherapy on diaphragm mobility and diaphragm thickness in breast cancer patients.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the study conducted and what was the measurement method?",{"text":117,"@type":113},"Thirty diagnosed breast cancer patients were included in a cross-sectional design; ethical clearance and informed consent were obtained, and ultrasonography was used to assess diaphragm mobility and thickness before chemotherapy and after 5 weeks.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings after 5 weeks of chemotherapy?",{"text":121,"@type":113},"The study reported statistically significant changes, concluding that patients showed a significant decline in diaphragm mobility and diaphragm thickness following 5 weeks of chemotherapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},639379,1792811614,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962093270004,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Effect of Chemotherapy on Diaphragm Mobility and Diaphragm Thickness in Breast Cancer Patients: An  \nObservational Study  \nDr. Apurva Bipin Joshi1, Dr. Abhijit Diliprao Diwate2, Dr. Arijit Kumar Das3  \n1Department of Cardiovascular and Respiratory Physiotherapy , 2Department of Cardiovascular and Respiratory Physiotherapy, 3Department of Cardiovascular and Respiratory Physiotherapy DVVPF’s College of Physiotherapy, MUHS University, Ahmednagar, India.  \nCorresponding Author: Dr. Apurva Bipin Joshi  \nDOI: [https://doi.org/10.52403/ijhsr.20241034](https://doi.org/10.52403/ijhsr.20241034)  \nABSTRACT  \nBackground: Breast cancer being the common malignancy that affect many women nowadays and those patients with breast cancer often experience dyspnea after chemotherapy associated with the chemotherapy-induced injury of respiratory muscles and peripheral nerves. Also, Chemotherapy is known to induce diverse side effects including damage to the mitochondrial DNA.  \nObjective: To find out the effect of chemotherapy on diaphragm mobility and diaphragm thickness in breast cancer patients.  \nMaterials & Method: The study was conducted with 30 diagnosed breast cancer patients who met the inclusion criteria using a cross-sectional research design. After approval of ethical clearance, informed consent was obtained from the participants. Data was collected by Ultrasonography before starting of chemotherapy and after 5 weeks of chemotherapy. Demographic data and baseline measures were recorded before starting the examination. The collected data were measured using the open Epi Instat version for Windows statistical software.  \nResult: In the present study of 30 patients, the mean age group was 50.23±12.31, height 157.03±5.18, weight 56±6.0 . In our study, we found a result showing statistically significant changes in diaphragm mobility and diaphragm thickness in breast patients.  \nConclusion: The study concludes that patients with breast cancer showed significant decline in diaphragm mobility and diaphragm thickness after administration of 5 weeks of chemotherapy.  \nKeywords: Diaphragm mobility, Diaphragm thickness, Breast cancer, respiratory muscles, Ultrasonography.  \nINTRODUCTION  \nBreast cancer is seen to be the most common malignancy affecting women and its incidence is increasing by 1% per year. Nowadays it is often detected at an early stage and it is often managed with surgery, radiotherapy and systemic chemotherapy.1  \nIn 2020, approximately 2.3 million cases of breast cancer were diagnosed globally, and about 685,000 women died from the disease.2 As per the prediction by GLOBOCAN cancer cases in India would rise up to 2.08 million, accounting for a  \nincrease of 57.5 per cent in 2040 from 2020.3  \nPatients with breast cancer often experience dyspnea after chemotherapy, which might be associated with the chemotherapyinduced injury of respiratory muscles and peripheral nerves.4  \nAge, reproductive factors, personal or family history of breast disease, genetic predisposition and environmental factors have been associated with an increased risk for the development of female breast cancer.5 Breast cancer typically causes no pain and manifests as a lump in the breast. Nonetheless, 90% of breast masses including fibroadenomata, cysts, and fibrocystic change - are benign in nature. Breast cancer symptoms can include a bulge in the breast or axilla that may have hard, stationary, swelling of breast tissue or alterations in size and shape, skin abnormalities include ulceration, pitting, erythema, and dimpling, changes in the breasts, including inversion, skin changes, or discharge.6  \nThe diaphragm being the major muscle of respiration, its dysfunction is an underestimated cause of respiratory impairment in postsurgical patients.7  \nChemotherapy is known to induce diverse side effects including damage to the mitochondrial DNA. Doxorubicin (DOX) is a well-known anticancer drug for treating solid tumors and hematologic malignancies. DOX is a drug","cbCaiiQcEcBc5aHp","https://ap.wps.com/l/cbCaiiQcEcBc5aHp","pdf",213159,"English","# Abstract\n## Background and Objective\n## Materials & Method\n## Result and Conclusion\n# Introduction\n# Materials & Methods","[{\"question\":\"What was the objective of the observational study?\",\"answer\":\"To determine the effect of chemotherapy on diaphragm mobility and diaphragm thickness in breast cancer patients.\"},{\"question\":\"How was the study conducted and what was the measurement method?\",\"answer\":\"Thirty diagnosed breast cancer patients were included in a cross-sectional design; ethical clearance and informed consent were obtained, and ultrasonography was used to assess diaphragm mobility and thickness before chemotherapy and after 5 weeks.\"},{\"question\":\"What were the main findings after 5 weeks of chemotherapy?\",\"answer\":\"The study reported statistically significant changes, concluding that patients showed a significant decline in diaphragm mobility and diaphragm thickness following 5 weeks of chemotherapy.\"}]","Effect of Chemotherapy on Diaphragm Mobility and Diaphragm Thickness in Breast Cancer Patients: An Observational Study | PDF",1792703347,18]