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\nFrancesca Granucci,  \nUniversity of Milano-Bicocca, Italy  \n*CORRESPONDENCE  \nKazuhisa Iwabuchi  \n [iwabuchi@juntendo.ac.jp](iwabuchi@juntendo.ac.jp)  \n†These authors have contributed equally to this work  \nRECEIVED 02 December 2025  \nREVISED 02 December 2025  \nACCEPTED 10 December 2025  \nPUBLISHED 22 December 2025  \nCITATION  \nIwabuchi K, Tsuji M and Kasahara K (2025) Editorial: The role of glycolipids and sphingolipids in the differentiation and function of innate immune cells.  \nFront. Immunol. 16:1758633 .  \ndoi: 10.3389/fimmu.2025.1758633  \nCOPYRIGHT  \n© 2025 Iwabuchi, Tsuji and Kasahara. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nEditorial: The role of glycolipidsand sphingolipids in the differentiation and function of innate immune cells  \nKazuhisa Iwabuchi 1,2,3*†, Moriya Tsuji 4† and Kohji Kasahara 5†  \n1 Faculty of Pharmacy, Juntendo University, Urayasu, Japan, 2Advanced Research Center for Health Drug Discovery, Graduate School of Medicine, Juntendo University, Urayasu, Japan, 3 Institute for Environmental and Gender-specific Medicine, Graduate School of Medicine, Juntendo University, Urayasu, Japan, 4Aaron Diamond AIDS Research Center, Division of Infectious Diseases, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States, 5 Biomembrane Group, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan  \nKEYWORDS  \ndifferentiation, glycolipids, immune response, infection, innate immunity, lymphocytes, macrophages, neutrophils  \nEditorial on the Research Topic  \nThe role of glycolipids and sphingolipids in the differentiation and function of innate immune cells  \nRecent immunology research highlights the essential roles of glycolipids and sphingolipids in directing the differentiation and functions of innate immune cells, including macrophages, neutrophils, and innate T cells. These lipids support pathogen recognition, while many microorganisms exploit their own glycolipids to evade host defenses; for example, Mycobacterium tuberculosis uses mannose-capped lipoarabinomannan to inhibit phagocyte maturation. Innate immune cells have therefore evolved mechanisms to detect and eliminate diverse pathogen-derived glycolipids. Lipid rafts, membrane microdomains enriched in glycolipids and cholesterol, also regulate key signaling processes related to hemostasis and thrombosis. CD1 molecules present lipid antigens to NKT cells, thereby linking innate and adaptive immunity. Despite these advances, deeper insight is needed into how host-and pathogen-derived lipids influence immune cell development and host–pathogen interactions. This Research Topic comprises five original articles and one review article, which collectively describe how glycolipids and sphingolipids regulate innate immune cell differentiation and how pathogen-derived glycolipids affect both innate and cell-mediated immune responses.  \nDong et al. reviewed the synthesis and physiological functions of glycosphingolipids (GSLs), as well as their roles in disease and therapeutic applications. Anti-ganglioside and other tumor-associated antibodies show antitumor activity in certain patients. Several viruses, pathogens, and toxins exploit GSLs as cellular receptors. Gangliosides have also been proposed as potential co-receptors or attachment factors that facilitate ACE2-dependent entry of SARS-CoV-2, and inhibitors of glucosylceramide synthase suppress SARS-CoV-2 replication. These findings und","cbCaigjw4cTx2OjA","https://ap.wps.com/l/cbCaigjw4cTx2OjA","pdf",305582,"English","# Editorial on the Research Topic\n## The role of glycolipids and sphingolipids in the differentiation and function of innate immune cells\n## Summary of included articles","[{\"question\":\"What is the central focus of this editorial?\",\"answer\":\"It centers on how glycolipids and sphingolipids regulate the differentiation and functions of innate immune cells and how lipid-derived interactions influence host–pathogen outcomes.\"},{\"question\":\"How do pathogens interact with host glycolipids or sphingolipids?\",\"answer\":\"The text notes that many microorganisms exploit their own glycolipids to evade host defenses, including examples such as Mycobacterium tuberculosis impairing phagocyte maturation.\"},{\"question\":\"Which molecular systems are highlighted as linking lipid biology to immunity?\",\"answer\":\"The editorial highlights lipid rafts for signaling regulation and CD1 molecules for presenting lipid antigens to NKT cells, connecting innate and adaptive immunity.\"}]","Editorial - The role of glycolipids and sphingolipids in the differentiation and function of innate immune cells | PDF",1790680083]