[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-336321-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-336321-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","editorial-the-rna-revolution-and-cancer-a-research-topic-overview","Editorial: The RNA revolution and cancer - A Research Topic Overview","","Editorial outlining how RNA biology is reshaping understanding and treatment of cancer, with emphasis on endocrine-related malignancies. Highlights mechanisms including alternative splicing, noncoding RNA regulation, and post-transcriptional processes that drive tumor heterogeneity and behavior. Notes clinical translation through aberrant RNA signatures as potential diagnostic and prognostic biomarkers, and reports recent work identifying therapeutic targets and personalized-treatment opportunities.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/editorial-the-rna-revolution-and-cancer-a-research-topic-overview/336321/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/editorial-the-rna-revolution-and-cancer-a-research-topic-overview/336321.png","ImageObject",300,407,{"name":42,"@type":43},"Ivy","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What role does RNA biology play in cancer understanding and treatment?","Question",{"text":63,"@type":64},"RNA biology has significantly advanced cancer research by explaining how RNA-centered processes influence tumor heterogeneity and behavior, especially in endocrine-related malignancies.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which RNA mechanisms are highlighted as important in endocrine-related cancers?",{"text":68,"@type":64},"The editorial emphasizes alternative splicing, regulation by noncoding RNAs (microRNAs, long noncoding RNAs, and circular RNAs), and multiple post-transcriptional processes including RNA methylation.",{"name":70,"@type":61,"acceptedAnswer":71},"How can RNA-related findings support clinical applications like diagnosis and therapy?",{"text":72,"@type":64},"Aberrant RNA signatures are presented as promising diagnostic and prognostic biomarkers, while targeting dysregulated RNA pathways is described as a route toward precision therapies for endocrine-related cancers.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},336321,1790872578,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":33,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":123},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","TYPE Editorial  \nPUBLISHED 20 May 2024  \nDOI 10.3389/fendo.2024.1422599  \nOPEN ACCESS  \nEDITED AND REVIEWED BY Darko Stefanovski,  \nUniversity of Pennsylvania, United States  \n*CORRESPONDENCE Zodwa Dlamini  \n [zodwa.dlamini@up.ac.za](zodwa.dlamini@up.ac.za)  \nRECEIVED 24 April 2024  \nACCEPTED 01 May 2024  \nPUBLISHED 20 May 2024  \nCITATION  \nDlamini Z, Ladomery MR and Kahraman A (2024) Editorial: The RNA revolution and cancer.  \nFront. Endocrinol. 15:1422599 .  \ndoi: 10.3389/fendo.2024.1422599  \nCOPYRIGHT  \n© 2024 Dlamini, Ladomery and Kahraman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nEditorial: The RNA revolution and cancer  \nZodwa Dlamini 1*, Michael R. Ladomery 2 and Abdullah Kahraman 3,4  \n1SAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP), University of Pretoria, Pretoria, South Africa, 2School of Applied Sciences, University of the West of England, Bristol, United Kingdom, 3School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland, 4Swiss Institute of Bioinformatics, Lausanne, Switzerland  \nKEYWORDS  \nRNA biology, cancer, endocrine-related cancers, alternative splicing, noncoding RNAs, microRNAs, long noncoding RNAs, circular RNAs  \nEditorial on the Research Topic The RNA revolution and cancer  \nRNA biology has revolutionized cancer understanding and treatment, especially in endocrine-related malignancies. This editorial highlights RNA's crucial role in cancer progression, emphasizing its influence on tumor heterogeneity and behavior. Processes like alternative splicing and noncoding RNA regulation shape cancer biology, with microRNAs, long noncoding RNAs, and circular RNAs orchestrating gene expression dynamics. Aberrant RNA signatures hold promise as diagnostic and prognostic biomarkers in endocrine-related cancers. Recent findings, such as aberrant PI3Kd splice isoforms and epithelialmesenchymal transition-related lncRNA signatures, unveil potential therapeutic targets for personalized treatments. Insights into m6A-associated lncRNA prognostic models and the function of lncRNA LINC00659 in gastric cancer represents ongoing research in this field. As understanding of RNA's role in cancer expands, personalized therapies offer transformative potential in managing endocrine-related malignancies. This signifies a significant stride towards precision oncology, fostering innovation for more effective cancer care.  \nIntroduction  \nOver the last decades, molecular biology has seen remarkable discoveries that have increased our understanding of the molecular heterogeneity of cancer, including endocrinerelated malignancies. A critical area that has seen significant development is RNA biology, which has been marked by a major increase in research articles covering its various facets. This growth in RNA biology literature has provided insights into the direct roles of RNA in cellular functions, illuminating the functional flexibility and structural intricacy of RNA molecules. Furthermore, there has been extensive development in understanding how  \nFrontiers in Endocrinology 01 [frontiersin.org](frontiersin.org)  \nproteins recognize and bind RNA sequences and structures (1). Also, it is now apparent that RNA-centered processes regulate gene expression in multiple ways, including co-transcriptional premRNA processing, alternative splicing, mRNA translation, localization, stability, and editing (2, 3) . The advent of regulatory noncoding RNAs, such as microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RN","cbCaig5iEcjO21cT","https://ap.wps.com/l/cbCaig5iEcjO21cT","pdf",492878,"English","# Editorial on the Research Topic The RNA revolution and cancer\n## Introduction\n## Aberrantly spliced isoforms, noncoding RNAs, and endocrine-related malignancies\n## Biomarker and targeted therapy prospects\n## Conclusion","[{\"question\":\"What role does RNA biology play in cancer understanding and treatment?\",\"answer\":\"RNA biology has significantly advanced cancer research by explaining how RNA-centered processes influence tumor heterogeneity and behavior, especially in endocrine-related malignancies.\"},{\"question\":\"Which RNA mechanisms are highlighted as important in endocrine-related cancers?\",\"answer\":\"The editorial emphasizes alternative splicing, regulation by noncoding RNAs (microRNAs, long noncoding RNAs, and circular RNAs), and multiple post-transcriptional processes including RNA methylation.\"},{\"question\":\"How can RNA-related findings support clinical applications like diagnosis and therapy?\",\"answer\":\"Aberrant RNA signatures are presented as promising diagnostic and prognostic biomarkers, while targeting dysregulated RNA pathways is described as a route toward precision therapies for endocrine-related cancers.\"}]","Editorial: The RNA revolution and cancer - A Research Topic Overview | PDF",1790014529]