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Key themes include genetic testing and targeted imaging, including targeted contrast-enhanced ultrasound strategies for aggressive disease, and combined ultrasound with gene analysis to predict invasiveness in papillary thyroid microcarcinoma. 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Antonino Belfiore, University of Catania, Italy  \n*CORRESPONDENCE Bo Zhang  \n [thyroidus@163.com](thyroidus@163.com)  \nRECEIVED 30 April 2023  \nACCEPTED 10 May 2023  \nPUBLISHED 17 May 2023  \nCITATION  \nTang J, Ma J, Huo S, Xi X, Li H, Wang L, Sun Z, Liu X and Zhang B (2023) Editorial:  \nThe clinical application and progress of precise diagnosis and treatment of thyroid tumors.  \nFront. Endocrinol. 14:1214596 .  \ndoi: 10.3389/fendo.2023.1214596  \nCOPYRIGHT  \n© 2023 Tang, Ma, Huo, Xi, Li, Wang, Sun, Liu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nEditorial: The clinical application and progress of precise diagnosis and treatment of thyroid tumors  \nJiajia Tang 1,2, Jiaojiao Ma 1, Shirui Huo 3, Xuehua Xi 1, Huilin Li 1,2, Liangkai Wang 1,4, Zhe Sun 1,2, Xinyi Liu 1,5 and Bo Zhang 2,6*  \n1 Department of Ultrasound, China-Japan Friendship Hospital, Beijing, China, 2Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 3 Beijing University of Chinese Medicine, Beijing, China, 4 Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, China, 5Capital Medical University, Beijing, China, 6 Department of Ultrasound, China-Japan Friendship Hospital, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine of Chinese Academy of Medical Sciences, Beijing, China  \nKEYWORDS  \nthyroid tumors, targeted imaging, gene analysis, etiology factors, prognostic model, minimally-invasive therapy  \nEditorial on the Research Topic  \nThe clinical application and progress of precise diagnosis and treatment of thyroid tumors  \nThyroid tumors are common and have become a significant public health concern worldwide. Precise diagnosis and treatment of thyroid tumors are essential for effective disease management and improved outcomes. In recent years, significant advancements in medical research and technology have led to the development of new diagnostic and treatment strategies for thyroid tumors.  \nOne of the most promising developments of thyroid tumors is the application of genetic testing and targeted diagnosis. This has enabled clinicians to identify high-risk patients and tailor treatments to the specific genetic mutations in the thyroid tumors. Ma et al. described the development of a targeted microbubble contrast agent for specific contrast-enhanced ultrasound (CEUS) imaging of highly invasive thyroid cancer. The microbubbles were prepared by coupling a peptide with high affinity and specificity for bgalactoside-binding protein galectin-3 (Gal-3) to the surface of lipid microbubbles and demonstrated good stability and biosafety. The microbubbles showed superior targeting ability to Gal-3 overexpressing BCPAP cells, significantly improving the CEUS imaging of highly invasive thyroid cancer in a mouse model. This study provides an innovative approach for the specific ultrasound imaging diagnosis of highly aggressive thyroid cancer, which assists in improving the precise diagnosis of thyroid tumors and reducing unnecessary treatment interventions. In a separate study, Yan et al. predicted the invasiveness of papillary thyroid microcarcinoma (PTMC) by combining ultrasound and the WNT10A gene analysis to evaluate the invasive capability of PTMC. The expression level of WNT10A was higher in the invasive group than in the non-invasive group. The risk factors for PTMC invasiveness included age, maximum nodule diameter,  ","cbCaipmyizbouLeN","https://ap.wps.com/l/cbCaipmyizbouLeN","pdf",246664,"English","# Editorial on the Research Topic\n## Precise diagnosis and targeted treatment advances\n## Genetic testing and targeted imaging\n## Ultrasound and gene analysis for invasiveness prediction\n## Environmental, social, and individual risk factors\n## Prognostic prediction in rare thyroid malignancy","[{\"question\":\"What is the main focus of this editorial?\",\"answer\":\"It focuses on the clinical application and recent progress in precise diagnosis and treatment strategies for thyroid tumors, emphasizing improved disease management and outcomes.\"},{\"question\":\"How does genetic testing contribute to thyroid tumor care according to the text?\",\"answer\":\"Genetic testing enables identification of high-risk patients and supports tailored treatment based on specific genetic mutations, and it is discussed alongside targeted diagnostic approaches.\"},{\"question\":\"Which diagnostic and analytical factors are discussed as risk-related for thyroid cancer?\",\"answer\":\"The text discusses environmental and social determinants such as air pollution, green space, economic status, and healthcare level, as well as patient-level factors like BMI at the time of initial nodule evaluation.\"}]","Editorial - The clinical application and progress of precise diagnosis and treatment of thyroid tumors | PDF",1790271394]