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\nEDITED AND REVIEWED BY Peter Brossart,  \nUniversity of Bonn, Germany  \n*CORRESPONDENCE Hao Chi  \n [Chihao7511@163.com](Chihao7511@163.com)[ ](Chihao7511@163.com)Guanhu Yang  \n [gy182915@ohio.edu](gy182915@ohio.edu)[ ](gy182915@ohio.edu)Gang Tian  \n [tiangang@swmu.edu.cn](tiangang@swmu.edu.cn)  \n†These authors have contributed equally to this work  \nRECEIVED 29 April 2024  \nACCEPTED 10 May 2024  \nPUBLISHED 16 May 2024  \nCITATION  \nChi H, Jiang L, Zhang S, Liu Y, Yang G and Tian G (2024) Editorial: Targeting key cellular signaling network for cancer chemotherapy and immunotherapy.  \nFront. Immunol. 15:1425261 .  \ndoi: 10.3389/fimmu.2024.1425261  \nCOPYRIGHT  \n© 2024 Chi, Jiang, Zhang, Liu, Yang and Tian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nEditorial: Targeting key cellular signaling network for  \ncancer chemotherapy and immunotherapy  \nHao Chi 1*†, Lai Jiang 1†, Shengke Zhang 1†, Yunfei Liu 2†, Guanhu Yang 3* and Gang Tian 4,5,6*  \n1Clinical Medical College, Southwest Medical University, Luzhou, China, 2 Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany,  \n3 Department of Specialty Medicine, Ohio University, Athens, OH, United States, 4 Department of Clinical Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China,  \n5Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases, Luzhou, China, 6 Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Sichuan, China  \nKEYWORDS  \ncellular signaling network, cancer, chemotherapy, immunotherapy, tumor microenvironment (TME)  \nEditorial on the Research Topic  \nTargeting key cellular signaling network for cancer chemotherapy and immunotherapy  \n1 Introduction  \nCancer pathology is diversely complex, with the key lying in the deep understanding and strategic manipulation of cellular signaling networks (1) . In this Research Topic of the journal on “Targeting Key Cellular Signaling Networks for Cancer Chemotherapy and Immunotherapy,” 16 cutting edge articles have been accommodated. Most of these articles not only bring forth the enormous therapeutic potential of precisely targeting these pathways but also provide a deeper understanding of the various signaling networks and emphasize upon highly innovative strategies of combining chemotherapy with immunotherapy. Some of these strategies promise not only to enhance therapeutic efficacy but also to reduce cancer’s resistance to current treatments. We are at the cusp of a new dawn in the understanding of oncology, a time at which precision medicine is just about to come of age (2, 3). The articles presented in this Research Topic contain pathbreaking perspectives and futuristic approaches that might change the course offuture cancer treatment. The presented research ranges from fundamental biochemical insights to translational and clinical applications, pushing us to challenge the disease with more precision and fewer side effects.  \nThis editorial aims to shed light on this theme by summarizing and discussing some of the key articles in this Research Topic. These articles delve into various aspects including the interaction between TME and immunotherapy, the interaction between immune cell dynamicsand immunotherapy, new chemotherapy and therapeutic strategies, and molecular and cellular level mechanisms.  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \n2 Interactions between the tumor mi","cbCaihUofEuDHxTA","https://ap.wps.com/l/cbCaihUofEuDHxTA","pdf",326572,"English","# Introduction\n# Interactions between the tumor microenvironment and immunotherapy","[{\"question\":\"What is the main purpose of the editorial in this Research Topic?\",\"answer\":\"It summarizes and discusses key articles focused on targeting cellular signaling networks for cancer chemotherapy and immunotherapy, highlighting major insights and future directions.\"},{\"question\":\"Which research themes are emphasized across the included articles?\",\"answer\":\"The editorial highlights interactions between the TME and immunotherapy, immune cell dynamics with immunotherapy, new chemotherapy and therapeutic strategies, and underlying molecular and cellular mechanisms.\"},{\"question\":\"How does the tumor microenvironment influence immunotherapy according to the editorial?\",\"answer\":\"The editorial explains that the TME is a complex system of tumor, immune, fibroblast, vascular cells, and extracellular matrix, which interact via cytokines, growth factors, and chemokines and can modulate responses to immunotherapy.\"}]","Editorial: Targeting key cellular signaling network for cancer chemotherapy and immunotherapy - Editorial on the Research Topic | PDF",1789996801]