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It discusses how similarities between cancer and normal cells drive toxicity and the need for dose or regimen adaptation. The editorial highlights precision medicine informed by individual genetic aberrations and coping mechanisms that contribute to drug resistance. It previews review studies on lncRNAs in radioresistance, antibody-drug conjugates for advanced gastric cancer, and personalized treatment strategies for triple-negative breast cancer, plus a real-world analysis of EPM2A in prostate cancer.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/editorial-new-mechanistic-insights-into-cancer-precision-medicine/384479/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/editorial-new-mechanistic-insights-into-cancer-precision-medicine/384479.png","ImageObject",300,407,{"name":92,"@type":93},"MrHarris58","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are precise anticancer mechanisms important in precision medicine?","Question",{"text":112,"@type":113},"They help reduce severe side effects by improving drug specificity. Cancer cells can resemble normal cells, so accurate targeting is crucial to limit toxicity and improve tolerability.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What key topics do the editorial’s included review articles cover?",{"text":117,"@type":113},"The editorial highlights reviews on lncRNAs in tumor radioresistance/sensitivity, antibody–drug conjugates in advanced gastric cancer, and personalized clinical treatment strategies for triple-negative breast cancer.",{"name":119,"@type":110,"acceptedAnswer":120},"How does EPM2A relate to prostate cancer treatment options in the described study?",{"text":121,"@type":113},"Higher EPM2A is associated with greater sensitivity to immunotherapy, while lower EPM2A corresponds to better suitability for bicalutamide, cisplatin, and paclitaxel therapy. 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Pharmacol. 14:1159703 .  \ndoi: 10.3389/fphar.2023.1159703  \nCOPYRIGHT  \n© 2023 Kwok. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nEditorial: New mechanistic insights into cancer precision medicine  \nHang Fai Kwok 1,2,3*  \n1Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China, 2Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China, 3MoE Frontiers Science Center for Precision Oncology, University of Macau, Avenida de Universidade, Taipa, Macau SAR, China  \nKEYWORDS  \nimmunotherapy, targeted therapy, therapeutic antibody, chemotherapy, novel bioactive molecule, biomarker, drug resistance  \nEditorial on the Research Topic  \nNew mechanistic insights into cancer precision medicine  \nAnticancer drugs’ specificity and precise mechanism are crucial in reducing the severity of side effects associated with the drugs’ use. However, due to the similarity between cancer cells and non-cancerous (normal) cells in our body, anticancer agents are generally toxic to normal cells that can cause numerous side effects, some of which are life-threatening. Those adverse effects may require that the drug dosages are reduced, or the drug regimen be changed to make the drugs tolerable to the patients. In the last decade, many studies have been performed to understand cancer’s response by considering the individual aberrant genetic background, which yields essential information for precision medicine. Furthermore, exploring the coping mechanisms of the malignancy after exposure to drug treatments provides hints about compensatory strategies resulting in drug resistance and how to tackle the “Achilles heel” of cancer progression with a recently developed idea on a precision medicine approach.  \nIn this Research Topic, we brought together leading researchers to exchange and share their findings on the hot topics of the latest mechanistic insights into cancer precision medicine. There are three review articles in this Research Topic. One review is a Long Noncoding RNA study on the cancer radioresistance/radiosensitivity (Wu et al.) . The authors performed a systematic review and summarised that lncRNAs are important regulators in tumor radioresistance/sensitivity. Different lncRNAs may participate in the radioresistance with the same regulatory paradigm. In addition, the same lncRNAs may also participate in the radioresistance differently. Future research should focus more on comprehensively characterising the mechanisms of lncRNAs in tumor radioresistance to help us identify corresponding novel biomarkers.  \nThe second review article systematically analysed the recent progress of antibody–drug conjugates (ADCs) in advanced gastric cancer therapy (Wand et al.). Based on their analyses, ADCs are valid and well-tolerated anticancer drugs whose development is a tremendous breakthrough in tumor therapy and the linchpin of AGC treatment. The authors suggest that optimising each ADC component is one of the es","cbCaiu9Bi1x3ebOI","https://ap.wps.com/l/cbCaiu9Bi1x3ebOI","pdf",519510,"English","# Editorial on the Research Topic\n## Anticancer drug specificity and precision mechanisms\n## Precision medicine and mechanisms of drug resistance\n## Featured review articles: lncRNAs, ADCs, and TNBC personalized treatment\n## Additional study: EPM2A in prostate cancer","[{\"question\":\"Why are precise anticancer mechanisms important in precision medicine?\",\"answer\":\"They help reduce severe side effects by improving drug specificity. Cancer cells can resemble normal cells, so accurate targeting is crucial to limit toxicity and improve tolerability.\"},{\"question\":\"What key topics do the editorial’s included review articles cover?\",\"answer\":\"The editorial highlights reviews on lncRNAs in tumor radioresistance/sensitivity, antibody–drug conjugates in advanced gastric cancer, and personalized clinical treatment strategies for triple-negative breast cancer.\"},{\"question\":\"How does EPM2A relate to prostate cancer treatment options in the described study?\",\"answer\":\"Higher EPM2A is associated with greater sensitivity to immunotherapy, while lower EPM2A corresponds to better suitability for bicalutamide, cisplatin, and paclitaxel therapy. The study also builds a nomogram risk model for individualized predictions.\"}]","Editorial: New mechanistic insights into cancer precision medicine | PDF",1790263565]