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Stromal cells are presented as integral immune components that shape tissue homeostasis, inflammatory responses, and disease progression across multiple systems. Advances in omics, including single-cell and spatial transcriptomics, reveal stromal molecular phenotypes and their function as immune sentinels, while receptor-ligand bioinformatic tools clarify dysregulated immune–stromal crosstalk. The article highlights stromal subsets as therapeutic targets and modalities, summarizing reviews and studies on lymphoid architecture, germinal center regulation, ECM remodeling, and AAA and EMT-driven remodeling in asthma.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/editorial-exploring-immune-stromal-cell-dynamics-pathways-and-therapeutic-implications/416262/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/editorial-exploring-immune-stromal-cell-dynamics-pathways-and-therapeutic-implications/416262.png","ImageObject",300,407,{"name":92,"@type":93},"supergirl","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-07","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What role do immune-stromal cell dynamics play in disease?","Question",{"text":113,"@type":114},"They contribute bidirectionally to immune homeostasis and to immune system dysregulation that drives disease pathogenesis.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do omics technologies inform understanding of stromal cells?",{"text":118,"@type":114},"Single-cell and spatial transcriptomics reveal stromal molecular phenotypes and help identify how stromal cells regulate the inflammatory milieu.",{"name":120,"@type":111,"acceptedAnswer":121},"Why are stromal cell types considered in therapeutic research?",{"text":122,"@type":114},"Because they orchestrate immune responses, stromal subsets are investigated as therapeutic targets and as therapeutic modalities or approaches.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},416262,1791156957,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":24,"preview_page_count":4},962088121634,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","TYPE Editorial  \nPUBLISHED 15 December 2025 DOI 10.3389/fimmu.2025.1744273  \nOPEN ACCESS  \nEDITED AND REVIEWED BY  \nRaphaela Goldbach-Mansky,  \nNational Institute of Allergy and Infectious Diseases (NIH), United States  \n*CORRESPONDENCE  \nStephen B Gauld  \n [stephen.gauld@abbvie.com](stephen.gauld@abbvie.com)  \nRECEIVED 11 November 2025  \nACCEPTED 27 November 2025  \nPUBLISHED 15 December 2025  \nCORRECTED 19 December 2025  \nCITATION  \nRyu S, Gauld SB, Staron MM, Odell ID,  \nCash JL and Radstake TRDJ (2025) Editorial: Exploring immune-stromal cell dynamics: pathways and therapeutic implications. Front. Immunol. 16:1744273 .  \ndoi: 10.3389/fimmu.2025.1744273  \nCOPYRIGHT  \n© 2025 Ryu, Gauld, Staron, Odell, Cash and Radstake. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nEditorial: Exploring immune  \nstromal cell dynamics: pathways and therapeutic implications  \nStacy Ryu 1, Stephen B Gauld 1*, Matthew M Staron 1,  \nIan D Odell 2, Jenna L Cash 3 and Timothy RDJ Radstake 1  \n1Abbvie Inc., North Chicago, IL and Cambridge, MA, United States, 2 Department of Dermatology, Yale School of Medicine, Department of Immunobiology, Yale University School of Medicine, New Haven, CT, United States, 3Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, United Kingdom  \nKEYWORDS  \ntissue resident immune cells, fibroblast and immune crosstalk, tertiary lymphoid structures, cell-cell interactions, mesenchymal stem/stromal cells  \nEditorial on the Research Topic  \nExploring immune-stromal cell dynamics: pathways and therapeutic implications  \nBidirectional immune-stromal cell dynamics play a pivotal role in immune homeostasis and disease pathogenesis. Accumulating data demonstrates that stromal cells are more than mere structural components; rather, they constitute a key part of the immune system. Specifically, stromal cells have been shown to shape tissue homeostasis, inflammatory responses, and disease progression in various tissues-including pulmonary, lymphoid, and vascular systems. Advances in omics technologies (single cell and spatial transcriptomics) have uncovered the molecular phenotypes of stromal cells and illuminate their potential as key immune sentinels, capable of regulating the inflammatory milieu by detecting danger signals and releasing soluble mediators. Novel bioinformatic tools that enable analyses of complex receptor-ligand interactions have further uncovered how dysregulated crosstalk between immune and stromal cells can drive the initiation and progression of such disorders. Given their role as orchestrators of the immune response, stromal cell types are investigated both as therapeutic targets and as therapeutic modalities/approaches. The current Research Topic aims to deepen our understanding of the molecular profiles, mechanisms and pathways of stromal cells that govern immune cell regulation, while shedding light on their therapeutic potential.  \nYasmin et al. provided a comprehensive review on the architectural and functional diversity of stromal subsets in secondary lymphoid organs. The authors summarize key findings on the heterogeneous molecular phenotypes of distinct stromal populations such as fibroblastic reticular cells (FRCs), follicular dendritic cells (FDCs), marginal reticular cells, and adventitial cells in lymph nodes, spleen, and Peyer’s patches. These subsets occupy discrete anatomical niches throughout secondary lymphoid organs and provide scaffolding critical for immune cell migration, antigen presentation, germinal center (GC) formation and orchestration of ","cbCaicNSneKbSYEG","https://ap.wps.com/l/cbCaicNSneKbSYEG","pdf",303817,"English","# Editorial on the Research Topic\n## Exploring immune-stromal cell dynamics: pathways and therapeutic implications\n## Stromal cells as immune components and sentinels\n## Omics advances and receptor-ligand crosstalk tools\n## Stromal subsets in secondary lymphoid organs\n## Fibroblasts, FDCs, and germinal center orchestration\n## Disease microenvironments from immune-stromal interactions","[{\"question\":\"What role do immune-stromal cell dynamics play in disease?\",\"answer\":\"They contribute bidirectionally to immune homeostasis and to immune system dysregulation that drives disease pathogenesis.\"},{\"question\":\"How do omics technologies inform understanding of stromal cells?\",\"answer\":\"Single-cell and spatial transcriptomics reveal stromal molecular phenotypes and help identify how stromal cells regulate the inflammatory milieu.\"},{\"question\":\"Why are stromal cell types considered in therapeutic research?\",\"answer\":\"Because they orchestrate immune responses, stromal subsets are investigated as therapeutic targets and as therapeutic modalities or approaches.\"}]","Editorial - Exploring immune-stromal cell dynamics - pathways and therapeutic implications | PDF",1790604801]