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Using the caries ecology hypothesis, the text frames prevention around biofilm control and diet, noting that existing strategies remain insufficient and that the post-antibiotic era demands new approaches. It highlights emerging directions spanning antibiofilm materials, probiotics, and novel molecular targets.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":15,"@type":76,"position":81},"https://docshare.wps.com/document/literature/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/editorial-editorial-novel-strategies-for-caries-control/415368/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/editorial-editorial-novel-strategies-for-caries-control/415368.png","ImageObject",300,407,{"name":92,"@type":93},"Alex Sinclair","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is dental biofilm considered central to dental caries development?","Question",{"text":112,"@type":113},"Dental biofilm is described as a primary contributor to oral diseases, and caries is framed as a biofilm-mediated, sugar-driven, dynamic condition. The caries ecology hypothesis links sugar-driven imbalance in oral biofilms to caries development.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What new strategies are emphasized for caries control in the post-antibiotic era?",{"text":117,"@type":113},"The editorial calls for novel strategies targeting oral biofilms directly or modulating the oral environment. Examples include antibacterial agents and molecules, advanced antibiofilm dental materials, and probiotics.",{"name":119,"@type":110,"acceptedAnswer":120},"What do the discussed studies suggest about allulose and L-arginine?",{"text":121,"@type":113},"Allulose is reported to significantly reduce bacterial growth, acid production, and biofilm formation while maintaining higher microbial diversity in saliva-derived biofilms. 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Cell. Infect. Microbiol. 15:1756613 .  \ndoi: 10.3389/fcimb.2025.1756613  \nCOPYRIGHT  \n© 2025 Huang and Zandon´a . This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nEditorial: Novel strategies for caries control  \nXuelian Huang* and Andr´ea Ferreira Zandon´a  \nDivision of Restorative and Prosthetic Dentistry, The Ohio State University College of Dentistry, Columbus, OH, United States  \nKEYWORDS  \nartificial intelligence (AI), caries control, dental biofilm, dental caries, novel strategies, post-antibiotic era, probiotics  \nEditorial on the Research Topic  \nNovel strategies for caries control  \nDental biofilm (plaque) is one of the primary contributors in the development of oral diseases, including dental caries, a “biofilm-mediated, sugar-driven, multifactorial, dynamic disease that poses significant public health concerns.” Dental caries is more than a localized oral health concern—it is intricately linked to systemic health, underscoring its significance as a broader public health issue. According to the caries ecology hypothesis, a sugar-driven imbalance in oral biofilms triggers caries development, making biofilm control and dietary interventions central to caries prevention. Despite extensive research and clinical practice targeting oral biofilms, current strategies remain insufficient. In the Post-Antibiotic Era, there is an urgent need for the development of novel strategies for caries control whether through direct targeting of oral biofilms or through modulation of the oral environment.”  \nThis Research Topic assembles original research and reviews on novel caries control strategies, including: antibacterial agents and novel molecules (allulose, L-arginine, lysine acetylation), novel potential targets (fungi, particularly Candida albicans), advanced antibiofilm dental materials (anti-caries hydrogels, zein-based curcumin nanocapsules, drugdelivery nanosystems), probiotics (Lactobacillus salivarius), and novel strategies to prevent secondary caries.  \nHan et al. evaluated the cariogenic potential of allulose using multi-tiered in vitro models, including single-species, dual-species, and saliva-derived biofilms. Compared to sucrose, glucose, and fructose, allulose significantly reduced bacterial growth, acid production, and biofilm formation, resembling non-fermentable sugar alcohols such as xylitol and erythritol. Biofilms grown with allulose lacked dense EPS-rich structures, while saliva-derived biofilms maintained higher microbial diversity with health-associated genera. These findings suggest that allulose has low cariogenic potential and may serve as a non-cariogenic, microbiome-friendly sugar alternative.  \nGao et al. investigated the effects of L-arginine on key cariogenic oral microbes Streptococcus mutans and C. albicans. Using planktonic growth assays, biofilm biomass measurements, crystal violet staining, CFU counts, fluorescence in situ hybridization (FISH), and assessments of extracellular polysaccharide and lactic acid production in dual-species biofilms, they found that L-arginine inhibited both planktonic growth and biofilm formation in single-species and dual-species cultures, reduced biofilm adhesion, and suppresse","cbCaiu3y8HUSXN7E","https://ap.wps.com/l/cbCaiu3y8HUSXN7E","pdf",317221,"English","# Editorial on the Research Topic\n## Novel strategies for caries control\n## Molecular and material approaches","[{\"question\":\"Why is dental biofilm considered central to dental caries development?\",\"answer\":\"Dental biofilm is described as a primary contributor to oral diseases, and caries is framed as a biofilm-mediated, sugar-driven, dynamic condition. The caries ecology hypothesis links sugar-driven imbalance in oral biofilms to caries development.\"},{\"question\":\"What new strategies are emphasized for caries control in the post-antibiotic era?\",\"answer\":\"The editorial calls for novel strategies targeting oral biofilms directly or modulating the oral environment. Examples include antibacterial agents and molecules, advanced antibiofilm dental materials, and probiotics.\"},{\"question\":\"What do the discussed studies suggest about allulose and L-arginine?\",\"answer\":\"Allulose is reported to significantly reduce bacterial growth, acid production, and biofilm formation while maintaining higher microbial diversity in saliva-derived biofilms. L-arginine is reported to inhibit planktonic growth and biofilm formation, reduce adhesion, and suppress extracellular polysaccharide and acid production in dual-species settings.\"}]","Editorial - Editorial Novel strategies for caries control | PDF",1790601144]