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The review synthesizes current ovarian-cancer treatment options and challenges, outlines principles of tumor evolution, and proposes evolutionarily designed strategies to improve outcomes and counter drug resistance through ecological and evolutionary considerations.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/ecological-and-evolutionary-dynamics-to-design-and-improve-ovarian-cancer-treatment/328720/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/ecological-and-evolutionary-dynamics-to-design-and-improve-ovarian-cancer-treatment/328720.png","ImageObject",300,407,{"name":42,"@type":43},"Theodore","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why does ovarian cancer develop resistance to therapies?","Question",{"text":63,"@type":64},"Resistance emerges from evolutionary dynamics within the complex tumor microenvironment, heterogeneous cell populations, and the plasticity of individual cancer cells.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What treatment approaches are discussed for ovarian cancer?",{"text":68,"@type":64},"The text highlights PARP inhibitors, targeted therapies, and immunotherapies, used in sequential or combined treatment designs.",{"name":70,"@type":61,"acceptedAnswer":71},"What is the core idea behind eco-evolutionarily designed therapies?",{"text":72,"@type":64},"Therapies should account for cancer cell plasticity and patient-specific characteristics to improve clinical outcomes and prevent relapse.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},328720,1790186545,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},7971461740886,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","DOI: 10.1002/ctm2.70012  \nREVIEW  \nEcological and evolutionary dynamics to design and improve ovarian cancer treatment  \nGrace Y. Q. Han1   Monica Alexander2   Julia Gattozzi3  Marilyn Day4 Elayna Kirsch4  Narges Tafreshi5  Raafat Chalar6  Soraya Rahni7  Gabrielle Gossner8  William Burke8  Mehdi Damaghi6, 9, 10  \n1 Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA  \n2 Department of Molecular and Cellular Biology, Stony Brook University, Stony Brook, New York, USA  \n3 Department of Molecular and Cellular Pharmacology, Stony Brook University, Stony Brook, New York, USA  \n4 Department of Obstetrics and Gynecology, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA  \n5 Cellinfinity Bio, New Haven, Connecticut, USA  \n6 Stony Brook Cancer Center, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA  \n7 Stony Brook University, Stony Brook, New York, USA  \n8 Department of Obstetrics and Gynecology, Stony Brook University Hospital, Stony Brook, New York, USA  \n9 Department of Pathology, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA  \n10 Department of Radiation Oncology, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA  \nCorrespondence  \nMehdi Damaghi, Department of Pathology, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA. Email:  \n[mehdi.damaghi@stonybrookmedicine.edu](mehdi.damaghi@stonybrookmedicine.edu)  \nGraphical Abstract  \n1. Tumours are ecosystems in which cancer and non-cancer cells interact and evolve in complex and dynamic ways.  \n2. Conventional therapies for ovarian cancer inevitably lead to the development of resistance because they fail to consider tumours’ heterogeneity and cellular plasticity.  \n3. Eco-evolutionarily designed therapies should consider cancer cell plasticity and patient-specific characteristics to improve clinical outcome and prevent relapse.  \nClin. Transl. Med. 2024;e70012 .  \n[https://doi.org/10.1002/ctm2.70012](https://doi.org/10.1002/ctm2.70012)  \n[wileyonlinelibrary.com/journal/ctm2](wileyonlinelibrary.com/journal/ctm2)  \nDOI: 10.1002/ctm2.70012  \nREVIEW  \nEcological and evolutionary dynamics to design and improve ovarian cancer treatment  \nGrace Y. Q. Han1   Monica Alexander2   Julia Gattozzi3  Marilyn Day4 Elayna Kirsch4  Narges Tafreshi5  Raafat Chalar6  Soraya Rahni7  Gabrielle Gossner8  William Burke8  Mehdi Damaghi6, 9, 10  \n1 Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA  \n2 Department of Molecular and Cellular Biology, Stony Brook University, Stony Brook, New York, USA  \n3 Department of Molecular and Cellular Pharmacology, Stony Brook University, Stony Brook, New York, USA  \n4 Department of Obstetrics and Gynecology, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA  \n5 Cellinfinity Bio, New Haven, Connecticut, USA  \n6 Stony Brook Cancer Center, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA  \n7 Stony Brook University, Stony Brook, New York, USA  \n8 Department of Obstetrics and Gynecology, Stony Brook University Hospital, Stony Brook, New York, USA  \n9 Department of Pathology, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA  \n10 Department of Radiation Oncology, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA  \nCorrespondence  \nMehdi Damaghi, Department of Pathology, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.  \nEmail:  \n[mehdi.damaghi@stonybrookmedicine.edu](mehdi.damaghi@stonybrookmedicine.edu)  \nFunding information  \nPhysical Sciences Oncology Network atthe National Cancer Institute through, Grant/Award Numbers: U01CA261841-01, R01CA249016-01; National Institutes of Health, Grant/Award Number:  \nR01CA249016-01; National Cancer Institute, Grant/Award Number:  \nU01CA","cbCaiibxcKMfZwfs","https://ap.wps.com/l/cbCaiibxcKMfZwfs","pdf",3267751,22,"English","# Graphical Abstract\n## Tumours as evolving ecosystems\n## Limits of conventional therapies\n## Eco-evolutionary therapy design\n# Abstract\n## Complexity and heterogeneity\n## Treatment modalities and resistance\n## Proposed evolution-focused strategies","[{\"question\":\"Why does ovarian cancer develop resistance to therapies?\",\"answer\":\"Resistance emerges from evolutionary dynamics within the complex tumor microenvironment, heterogeneous cell populations, and the plasticity of individual cancer cells.\"},{\"question\":\"What treatment approaches are discussed for ovarian cancer?\",\"answer\":\"The text highlights PARP inhibitors, targeted therapies, and immunotherapies, used in sequential or combined treatment designs.\"},{\"question\":\"What is the core idea behind eco-evolutionarily designed therapies?\",\"answer\":\"Therapies should account for cancer cell plasticity and patient-specific characteristics to improve clinical outcomes and prevent relapse.\"}]","Ecological and evolutionary dynamics to design and improve ovarian cancer treatment | PDF",1789980716,55]