[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-451768-105":59,"doc-detail-451768-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","echoes-of-the-struggle-with-cancer-cognitive-impairment-in-chinese-children","Echoes of the struggle with cancer - cognitive impairment in Chinese children","","Cancer-related cognitive impairment is a frequent complication in pediatric cancer care, limiting children’s return to school and normal family life. Evidence remains limited within China regarding how common CRCI is and which factors independently predict it. This multicenter cross-sectional study recruited 276 patients aged 6–16 to estimate CRCI prevalence and identify independent predictors using logistic regression, with results visualized via forest plots.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/echoes-of-the-struggle-with-cancer-cognitive-impairment-in-chinese-children/451768/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/echoes-of-the-struggle-with-cancer-cognitive-impairment-in-chinese-children/451768.png","ImageObject",300,407,{"name":92,"@type":93},"McGucket","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the purpose of the study on cancer-related cognitive impairment in Chinese children?","Question",{"text":112,"@type":113},"To determine the prevalence of cancer-related cognitive impairment (CRCI) and to identify independent predictors among pediatric cancer patients in China.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was CRCI prevalence and predictors assessed in the study?",{"text":117,"@type":113},"A convenience-sampled multicenter cross-sectional survey was conducted with 276 pediatric patients, using cognitive, anxiety, and sleep measures, followed by binary logistic regression and forest-plot visualization.",{"name":119,"@type":110,"acceptedAnswer":120},"Which factors were identified as independent predictors of cognitive impairment?",{"text":121,"@type":113},"The study found independent predictors including sleep disorders, parenting style, personality traits, age at initial diagnosis, number of chemotherapy sessions, and anxiety, along with effects of father’s educational level.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},451768,1791297480,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1236954412713,"https://us-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Chen et al. BMC Cancer (2026) 26:24 BMC Cancer  \n[https://doi.org/10.1186/s12885-025-15374-4](https://doi.org/10.1186/s12885-025-15374-4)  \nRESEARCH Open Access  \nEchoes of the struggle with cancer: cognitive impairment in Chinese children  \nZefang Chen 1,2,3,4, Ni Zhang2,3,4, Qian Liu8, Wenting Tan5, Qian Cai6, Xian Zhang7, Lu Yu2,3,4, Lifang Xu2,3,4, Chunhai Gao9, Tao Liu 1,3,4, Rongli Li2,3,4* and Lin Mo2,3,4*  \nAbstract  \nBackground Cancer-related cognitive impairment is a common complication among pediatric cancer patients, significantly hindering their return to school and family life. However, research on cancer-related cognitive impairment is still insufficient in China. This study aimed to investigate the prevalence and independent predictors of cancer-related cognitive impairment in pediatric cancer patients.  \nMethods Through convenience sampling, a multicenter cross-sectional survey was conducted in four hospitals in western, northern, and central China from September 2023 to August 2024. A total of 276 pediatric cancer patients aged 6 to 16 years old were recruited. Data was collected using a general information questionnaire, the Wechsler Intelligence Scale for Children-Fourth Edition Chinese Version (short form), the Spence Children’s Anxiety Scale-Short Version, and the sleep disturbances scale for children. Binary logistic regression analysis was performed to identify independent predictors of cognitive impairment and the results were visualized using a forest plot.  \nResults The Wechsler Intelligence Scale score of pediatric cancer patients was 93.85 ± 9.46, with cancer-related cognitive impairment prevalence rate of 34 . 1% . Binary logistic regression identified several independent predictors:  \nsleep disorders (OR = 2 . 85, 95% CI: 1.38–5. 86), parenting style (OR = 3 . 24, 95% CI: 1.46–7. 18), father’s educational level (OR = 0 . 10, 95% CI: 0 .02–0.40), personality trait (OR = 2 . 71, 95% CI: 1.31–5. 62), age at initial diagnosis (OR = 0 . 33, 95% CI: 0.17–0. 65), number of chemotherapy sessions (OR = 3 .42, 95% CI: 1.71–6. 84), and anxiety (OR = 2 . 51, 95% CI: 1.09–5. 78) . Conclusions Pediatric cancer patients exhibit lower cognitive function, influenced by a combination of sleep quality, family environment, age at diagnosis, anti-cancer treatment, and psychological factors. Clinical healthcare providers should accurately assess and identify cognitive impairments in these children and develop personalized intervention strategies based on their individual health status and influencing factors to enhance their cognitive abilities and improve their quality of life.  \nKeywords Children and adolescent, Cancer, Cancer-related cognitive impairment, Independent predictors, multicenter cross-sectional study  \n*Correspondence: Rongli Li [602541830@qq.com](602541830@qq.com)[ ](602541830@qq.com)Lin Mo[molin999@126.com](molin999@126.com)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creat","cbCaipjEaoHyLbGm","https://ap.wps.com/l/cbCaipjEaoHyLbGm","pdf",1494655,11,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What was the purpose of the study on cancer-related cognitive impairment in Chinese children?\",\"answer\":\"To determine the prevalence of cancer-related cognitive impairment (CRCI) and to identify independent predictors among pediatric cancer patients in China.\"},{\"question\":\"How was CRCI prevalence and predictors assessed in the study?\",\"answer\":\"A convenience-sampled multicenter cross-sectional survey was conducted with 276 pediatric patients, using cognitive, anxiety, and sleep measures, followed by binary logistic regression and forest-plot visualization.\"},{\"question\":\"Which factors were identified as independent predictors of cognitive impairment?\",\"answer\":\"The study found independent predictors including sleep disorders, parenting style, personality traits, age at initial diagnosis, number of chemotherapy sessions, and anxiety, along with effects of father’s educational level.\"}]","Echoes of the struggle with cancer - cognitive impairment in Chinese children | PDF",1790735892,28]