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It outlines EB-OCT structure and strengths, then summarizes applications across in vivo experiments and clinical studies, including differential diagnosis of airway lesions, early detection of lung cancer and lung nodules, lymph node biopsy localization, and palliative treatment support. Bottlenecks for clinical development and popularization are also analyzed, with OCT image characteristics aligning with pathology.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/eb-oct-a-potential-strategy-on-early-diagnosis-and-treatment-for-lung-cancer/381101/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/eb-oct-a-potential-strategy-on-early-diagnosis-and-treatment-for-lung-cancer/381101.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is early lung cancer diagnosis difficult with current screening methods?","Question",{"text":112,"@type":113},"Early diagnosis is hindered by limited value of available early screening strategies and the low specificity of symptoms, which contribute to low early-stage detection rates.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What advantages does EB-OCT offer for lung cancer detection?",{"text":117,"@type":113},"EB-OCT is described as non-invasive, accurate, and repeatable. It can provide real-time OCT image characteristics that are consistent with pathology for judging lesion nature.",{"name":119,"@type":110,"acceptedAnswer":120},"How can EB-OCT support clinical procedures beyond diagnosis?",{"text":121,"@type":113},"EB-OCT is presented as an assistant to biopsy of pulmonary nodules to improve biopsy success rates, and it also has an auxiliary role in treatment of lung cancer.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},381101,1790367231,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","TYPE Review  \nPUBLISHED 25 April 2023  \nDOI 10.3389/fonc.2023.1156218  \nOPEN ACCESS  \nEDITED BY  \nQinglin Shen,  \nJiangxi Provincial People ’s Hospital, China  \nREVIEWED BY  \nCornelia M. Wilson,  \nCanterbury Christ Church University, United Kingdom  \nChia-Hao Liang,  \nNational Yang Ming Chiao Tung University, Taiwan  \n*CORRESPONDENCE Yang Yang  \n [18981838300@189.cn](18981838300@189.cn)  \n†These authors share first authorship  \nSPECIALTY SECTION  \nThis article was submitted to Thoracic Oncology, a section of the journal Frontiers in Oncology  \nRECEIVED 01 February 2023  \nACCEPTED 12 April 2023  \nPUBLISHED 25 April 2023  \nCITATION  \nLong H, Ji J, Chen L, Feng J, Liao J and Yang Y (2023) EB-OCT: a potential strategy on early diagnosis and treatment for lung cancer.  \nFront. Oncol. 13:1156218 .  \ndoi: 10.3389/fonc.2023.1156218  \nCOPYRIGHT  \n© 2023 Long, Ji, Chen, Feng, Liao and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nEB-OCT: a potential strategy on early diagnosis and treatment for lung cancer  \nHang Long 1†, Jiaqi Ji 1, Lijuan Chen 1, Jiayue Feng 2, Jie Liao 2 and Yang Yang 1*  \n1 Department of Respiratory and Critical Medicine, Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Sciences, Chengdu, Sichuan, China, 2 Department of Cardiology, Sichuan Provincial People’s Hospital, Sichuan Academy of Medical Sciences, Chengdu, Sichuan, China  \nLung cancer is the leading cause of cancer-related death in China and the world, mainly attributed to delayed diagnosis, given that currently available early screening strategies exhibit limited value. Endobronchial optical coherence tomography (EB-OCT) has the characteristics of non-invasiveness, accuracy, and repeatability. Importantly, the combination of EB-OCT with existing technologies represents a potential approach for early screening and diagnosis. In this review, we introduce the structure and strengths of EB-OCT. Furthermore, we provide a comprehensive overview of the application of EBOCT on early screening and diagnosis of lung cancer from in vivo experiments to clinical studies, including differential diagnosis of airway lesions, early screening for lung cancer, lung nodules, lymph node biopsy and localization and palliative treatment of lung cancer . Moreover, the bottlenecks and difficulties in developing and popularizing EB-OCT for diagnosis and treatment during clinical practice are analyzed. The characteristics of OCT images of normal and cancerous lung tissues were in good agreement with the results of pathology, which could be used to judge the nature of lung lesions in realtime. In addition, EB-OCT can be used as an assistant to biopsy of pulmonary nodules and improve the success rate of biopsy. EB-OCT also plays an auxiliary role in the treatment of lung cancer. In conclusion, EB-OCT is non-invasive, safe and accurate in real-time. It is of great significance in the diagnosis of lung cancer and suitable for clinical application and is expected to become an important diagnostic method for lung cancer in the future.  \nKEYWORDS  \nendobronchial optical coherence tomography, endobronchoscopy, lung cancer, diagnosis, treatment  \nAbbreviations: EB-OCT, Endobronchial optical coherence tomography; LDCT, Low-dose computed tomography; PET/CT, Positron emission tomography/computed tomography; HRCT, High-resolution computed tomography; TBLB, Transbronchial lung biopsy; TBNA, Transbronchial needle aspiration; FNA, Fine needle aspiration; OCT, optical coherence tomography; SPNS, Solitary pulmonary nodules; NIR, The near-infrared; EBUS, Endobronchial ultrasound; LUAD,","cbCaigwzFmBeQegx","https://ap.wps.com/l/cbCaigwzFmBeQegx","pdf",1164878,"English","# Introduction\n## Early screening and diagnostic challenges\n## Current tools and limitations\n# EB-OCT overview\n## Structure and strengths\n# Applications in early diagnosis and treatment\n## Airway lesion differential diagnosis\n## Early screening for lung cancer and nodules\n## Lymph node biopsy and localization\n## Palliative treatment support\n# Clinical bottlenecks and future outlook","[{\"question\":\"Why is early lung cancer diagnosis difficult with current screening methods?\",\"answer\":\"Early diagnosis is hindered by limited value of available early screening strategies and the low specificity of symptoms, which contribute to low early-stage detection rates.\"},{\"question\":\"What advantages does EB-OCT offer for lung cancer detection?\",\"answer\":\"EB-OCT is described as non-invasive, accurate, and repeatable. It can provide real-time OCT image characteristics that are consistent with pathology for judging lesion nature.\"},{\"question\":\"How can EB-OCT support clinical procedures beyond diagnosis?\",\"answer\":\"EB-OCT is presented as an assistant to biopsy of pulmonary nodules to improve biopsy success rates, and it also has an auxiliary role in treatment of lung cancer.\"}]","EB-OCT - a potential strategy on early diagnosis and treatment for lung cancer | PDF",1790243591]