[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-330380-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-330380-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","early-onset-gastrointestinal-cancer-an-epidemiological-reality-with-great-significance-and-implications","Early-onset gastrointestinal cancer - An epidemiological reality with great significance and implications","","Epidemiological evidence from multiple countries indicates a shift in many digestive system cancers toward younger onset ages, termed “early-onset cancer.” This pattern is most evident in colorectal cancer and also appears, to a lesser extent, in gastric, pancreatic, and biliary tract malignancies, while data on several other digestive neoplasms remain limited. The observed age change likely reflects environmental exposures beginning in early life, interacting with diet, gut microbiome alterations, obesity-related factors, and genetic susceptibility. Further studies are needed to quantify individual and combined effects and to measure population exposure using advanced technologies, alongside proposed actions for the research community.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/early-onset-gastrointestinal-cancer-an-epidemiological-reality-with-great-significance-and-implications/330380/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/early-onset-gastrointestinal-cancer-an-epidemiological-reality-with-great-significance-and-implications/330380.png","ImageObject",300,407,{"name":42,"@type":43},"Olivia Brown","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What does “early-onset cancer” mean in this article?","Question",{"text":63,"@type":64},"It refers to cancer appearing in any body organ at an age of less than 50 years.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which digestive cancers show the clearest early-onset shift?",{"text":68,"@type":64},"Colorectal cancer shows the most evident shift, with additional evidence in gastric cancer and, to a lesser degree, cancers of the pancreas and biliary tract.",{"name":70,"@type":61,"acceptedAnswer":71},"What factors does the article propose may drive this phenomenon?",{"text":72,"@type":64},"It suggests environmental influences, potentially starting in childhood, interacting with changes in eating habits, gut microbiome consistency, increasing obesity, and genetic factors. However, the individual carcinogenic effects of each factor remain largely unknown.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},330380,1790290178,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":108},16904993612988,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","| W | J | G | O | World Journal of\u003Cbr>Gastrointestinal Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Oncol 2024 March 15; 16(3): 583-597  \nDOI: 10.4251/wjgo.v16.i3.583 ISSN 1948-5204 (online)  \nEDITORIAL  \nEarly-onset gastrointestinal cancer: An epidemiological reality with great significance and implications  \nJohn K Triantafillidis, Konstantinos Georgiou, Manousos M Konstadoulakis, Apostolos E Papalois  \nSpecialty type: Oncology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): B, B  \nGrade C (Good): 0  \nGrade D (Fair): 0  \nGrade E (Poor): 0  \nP-Reviewer: Brisinda G, Italy; Majumdar APN, United States  \nReceived: November 24, 2023  \nPeer-review started: November 25, 2023  \nFirst decision: December 6, 2023  \nRevised: December 17, 2023  \nAccepted: January 11, 2024  \nArticle in press: January 11, 2024  \nPublished online: March 15, 2024  \nJohn K Triantafillidis, Department of IBD and GI Endoscopy, Metropolitan General Hospital, Holargos 15562, Athens, Greece. Hellenic Society for Gastrointestinal Oncology, 354 Iera Odos, Chaidari 12461, Attica, Greece  \nKonstantinos Georgiou, Manousos M Konstadoulakis, Apostolos E Papalois, 2nd Department of Surgery, University of Athens School of Medicine, Aretaieion Hospital, Athens 11528, Greece  \nCorresponding author: John K Triantafillidis, PhD, Professor Emerita, Department of IBD and GI Endoscopy, Metropolitan General Hospital, 264 Mesogeion Avenue, Holargos 15562, Athens, [Greece.](Greece. jktrian@gmail.com)[ jktrian@gmail.com](Greece. jktrian@gmail.com)  \nAbstract  \nDuring the last few years, epidemiological data from many countries suggest that the incidence and prevalence of many cancers of the digestive system are shifting from the older to the younger ages, the so-called “early-onset cancer”. This is particularly evident in colorectal cancer and secondarily in other malignant digestive neoplasms, mainly stomach and in a lesser degree pancreas, and biliary tract. It should be emphasized that data concerning digestive neoplasms, except for those referring to the colon and stomach, could be characterized as rather insufficient. The exact magnitude of the shift in younger ages is expected to become clearer shortly, as long as relevant epidemiological data from many parts of the world would be available. The most important question concerns the etiology of this phenomenon, since its magnitude cannot be explained solely by the better diagnostic methodology and the preventive programs applied in many countries. The existing data support the assumption that a number of environmental factors may play a primary role in influencing carcinogenesis, sometimes from childhood. Changes that have appeared in the last decades related mainly to eating habits, consistency of gut microbiome and an increase of obese people interacting with genetic factors, ultimately favor the process of carcinogenesis. Even these factors however, are not entirely sufficient to explain the age-related changes in the frequency of digestive neoplasms. Studies of the individual effect of each of the already known factors or factors likely to be involved in the etiology of this phenomenon and studies using state-of-the-art technologies to accurately determine the degree of the population exposure to these factors are required. In this article, we attempt to describe the epidemiological data supporting the ageshifting of digestive malignancies and their possible pathogenesis. Finally, we propose some measures regarding the attitude of the scientific community to this alarming phenomenon.  \n WJGO  [https://www.wjgnet.com](https://www.wjgnet.com) 583 March 15, 2024  Volume 16  Issue 3   \nTriantafillidis JK et al. Gastrointestinal cancer and epidemiology  \nKey Words: G","cbCait4srlXSCYlB","https://ap.wps.com/l/cbCait4srlXSCYlB","pdf",1735940,16,"English","# Abstract\n## Introduction","[{\"question\":\"What does “early-onset cancer” mean in this article?\",\"answer\":\"It refers to cancer appearing in any body organ at an age of less than 50 years.\"},{\"question\":\"Which digestive cancers show the clearest early-onset shift?\",\"answer\":\"Colorectal cancer shows the most evident shift, with additional evidence in gastric cancer and, to a lesser degree, cancers of the pancreas and biliary tract.\"},{\"question\":\"What factors does the article propose may drive this phenomenon?\",\"answer\":\"It suggests environmental influences, potentially starting in childhood, interacting with changes in eating habits, gut microbiome consistency, increasing obesity, and genetic factors. However, the individual carcinogenic effects of each factor remain largely unknown.\"}]","Early-onset gastrointestinal cancer - An epidemiological reality with great significance and implications | PDF",1789988556]