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Cancer Registry of Norway records were analyzed with age-standardized incidence rates and joinpoint regression to estimate annual and average annual percentage change. Results show a sustained rise in EOCRC (20–49 years), driven largely by left-sided colon and rectal cancers, while incidence in older groups remained stable or increased more recently.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/early-onset-colorectal-cancer-incidence-in-norway-a-national-registry-based-study-1993-2022-analyzing-subsite-and-morphology-trends/333029/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/early-onset-colorectal-cancer-incidence-in-norway-a-national-registry-based-study-1993-2022-analyzing-subsite-and-morphology-trends/333029.png","ImageObject",300,407,{"name":92,"@type":93},"Ophelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-13","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main purpose of the study on early-onset colorectal cancer in Norway?","Question",{"text":113,"@type":114},"To provide up-to-date incidence patterns of EOCRC, emphasizing age-specific differences in tumor site and morphology, using a largely screening-naive population.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which age group and tumor types drove the increase in EOCRC incidence?",{"text":118,"@type":114},"EOCRC in ages 20–49 increased, mainly caused by left-sided colon and rectal cancers.",{"name":120,"@type":111,"acceptedAnswer":121},"How did incidence trends differ between older age groups compared with EOCRC?",{"text":122,"@type":114},"Ages 50–74 showed stable overall incidence, while ages 75 and above had an increased incidence largely associated with right-sided colon cancer, with changes over time.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},333029,1790157710,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","ORIGINAL ARTICLE  \nEarly-onset colorectal cancer incidence in Norway: a national registry-based study (1993-2022) analyzing subsite and morphology trends  \nM. F. Ystgaard1, T. Å . Myklebust2 , 3, J. Smeby1, I. K. Larsen2, T. K. Guren1, E. H. Kure4, K. M. Tveit5, B. Glimelius6,  \nM. G. Guren1 , 5 􀀁 & J. Hamfjord1, 4, 7  \n1Department of Oncology, Oslo University Hospital, Oslo; 2Department of Registration, Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo; 3Department of Research and Innovation, Møre and Romsdal Hospital Trust, Ålesund; 4Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo; 5Division of Cancer Medicine, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; 6Department of Immunology, Genetics and Pathology, Uppsala university, Uppsala, Sweden; 7Lovisenberg Diaconal University College, Oslo, Norway  \nAvailable online 2 August 2024  \nBackground: The overall incidence of colorectal cancer (CRC) has decreased or stabilized in most high-income countries, but an increase is observed in adults \u003C50 years of age, termed early-onset colorectal cancer (EOCRC) .  \nMaterials and methods: We conducted a nationwide registry-based study to provide up-to-date incidence patterns of EOCRC, with an emphasis on age-specific differences in tumor site and morphology. We extracted data from the Cancer Registry of Norway, with completeness estimated to be >99% . We calculated age-standardized incidence rates and used joinpoint regression to provide annual percentage change (APC) and average annual percentage change (AAPC) . National screening started in Norway in 2022; hence, this study is on a largely screening-naive population.  \nResults: There were 107 523 cases of CRC diagnosed between 1993 and 2022 eligible for analysis. The incidence of EOCRC (20-49 years) increased by 66%(AAPC 1 .3), caused by left-sided colon and rectal cancers. The age group 50- 74 years had a stable overall incidence (AAPC e0 . 2) . In the age group 􀀃75 years, an increased incidence (AAPC 0 .8) was observed, mainly by right-sided colon cancer, which increased until 2016 (APC 2.5), followed by a decrease (APC e0 .9) . EOCRC adenocarcinomas increased by 77%(AAPC 1 .4) . Neuroendocrine neoplasms were rare (1 .4%), but increased in all age groups (AAPC 4 . 2) . EOCRC showed a significantly higher proportion of distant metastases at time of diagnosis compared with the age group 􀀃75 years (28 .6% versus 18 . 2%, P \u003C 0.001) .  \nConclusions: We observed a sustained increase in EOCRC, caused by left-sided colon and rectal cancers. Unlike countries with established screening programs, the incidence of the age group >50 years remained stable or increased, but declined in recent years.  \nKey words: early-onset, incidence, colorectal cancer, primary tumor location, neuroendocrine, adenocarcinoma  \nINTRODUCTION  \nColorectal cancer (CRC) is one of the most common malignancies worldwide and is the second leading cause of cancer death.1 Norway has a high incidence of CRC, which has been increasing until the past two decades, when it has subsequently leveled out.2,3 The incidence in most high-income countries has been either stable or decreasing, but there have been several reports of increasing incidence rates in younger adults( \u003C50years old), termed early-onset colorectal cancer (EOCRC) .4,5  \n*Correspondence to: Prof. Marianne G. Guren, Department of Oncology, Oslo University Hospital, P.O. Box 4956 Nydalen, Oslo N-0424, Norway. Tel: þ47 22 93 40 00  \n[E-mail:](E-mail: marianne.gronlie.guren@ous-hf.no)[ marianne.gronlie.guren@ous-hf.no](E-mail: marianne.gronlie.guren@ous-hf.no) (M. G. Guren).  \n2949-8198/© 2024 The Authors. Published by Elsevier Ltd on behalf of European Society for Medical Oncology. This is an open access article under the CC BY license ([http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/)).  \nCompared with late-onset CRC (LOCRC, a","cbCaif5T6jLeHH8b","https://ap.wps.com/l/cbCaif5T6jLeHH8b","pdf",592031,"English","# Background\n# Materials and methods\n# Results\n# Conclusions\n# Introduction\n## Epidemiology of colorectal cancer in Norway\n## Prognostic and molecular relevance of subsite\n## Rationale for studying neuroendocrine neoplasms and screening","[{\"question\":\"What is the main purpose of the study on early-onset colorectal cancer in Norway?\",\"answer\":\"To provide up-to-date incidence patterns of EOCRC, emphasizing age-specific differences in tumor site and morphology, using a largely screening-naive population.\"},{\"question\":\"Which age group and tumor types drove the increase in EOCRC incidence?\",\"answer\":\"EOCRC in ages 20–49 increased, mainly caused by left-sided colon and rectal cancers.\"},{\"question\":\"How did incidence trends differ between older age groups compared with EOCRC?\",\"answer\":\"Ages 50–74 showed stable overall incidence, while ages 75 and above had an increased incidence largely associated with right-sided colon cancer, with changes over time.\"}]","Early-onset colorectal cancer incidence in Norway: a national registry-based study (1993-2022) - analyzing subsite and morphology trends | PDF",1790000392,23]