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A de novo development process formulates 12 key questions and corresponding recommendations, supported by a comprehensive systematic review and meta-analysis. Evidence certainty and recommendation strength use the GRADE approach, with drafts reviewed internally and externally plus public hearings. 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To address this, the Korean Sepsis Alliance, affiliated with the Korean Society of Critical Care Medicine, developed the first sepsis treatment guidelines for Korea based on a comprehensive systematic review and meta-analysis.  \nMethods: A de novo method was used to develop the guidelines. Methodologies included determining key questions, conducting a literature search and selection, assessing the risk of bias, synthesizing evidence, and developing recommendations. The certainty of evidence and the strength of recommendations were determined using the Grading of Recommendations, Assessment, Development, and Evaluations approach. Draft recommendations underwent internal and external review processes and public hearings. The development of these guidelines was supported by a research grant from the Korean Disease Control and Prevention Agency.  \nResults: In these guidelines, we focused on early treatments for adult patients with sepsis and septic shock. Through the guideline development process, 12 key questions and their respective recommendations were formulated. These include lactate measurement, fluid therapies, target blood pressure, antibiotic administration, use of vasopressors and dobutamine, extracorporeal membrane oxygenation, and echocardiography.  \nConclusions: These guidelines aim to support medical professionals in making appropriate decisions about treating adult sepsis and septic shock. We hope these guidelines will increase awareness of sepsis and reduce its mortality rate.  \nKey Words: guidelines; outcome; sepsis; septic shock; treatment  \nINTRODUCTION  \nSepsis is a life-threatening condition characterized by a dysregulated host response to infection, leading to organ dysfunction. It is a significant global health issue, affecting approximately 50 million individuals annually and causing at least 11 million deaths worldwide [1,2]. In recent decades, advances in sepsis recognition and supportive care have led to improved  \nGuideline  \nReceived: August 3, 2024  \nRevised: September 6, 2024  \nAccepted: September 9, 2024  \nCorresponding author  \nSunghoon Park  \nDepartment of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, 22 Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang 14068, Korea Tel: +82-31-380-3715  \nFax: +82-31-380-3973  \n[Email: f2000tj@gmail.com](Email: f2000tj@gmail.com)  \n©2024 The Korean Society of Critical Care Medicine This is an Open Access article distributed under the terms of Creative Attributions Non-Commercial License ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[li-censes/by-nc/4.0/](li-censes/by-nc/4.0/)) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.  \n[https://www.accjournal.org](https://www.accjournal.org) 445  \nPark C, et al. Management of adult sepsis and septic shock  \noutcomes. However, studies indicate that mortality rates in Korea remain higher than in Western countries, and compliance with sepsis","cbCaiiPSSdXZ24PB","https://ap.wps.com/l/cbCaiiPSSdXZ24PB","pdf",33588765,230,"English","# Introduction\n## Background\n## Scope and intended use\n# Methods\n## Development approach\n## Evidence evaluation and review\n# Results\n## Key questions and recommendations\n# Conclusions","[{\"question\":\"What problem do these guidelines target in Korea?\",\"answer\":\"High mortality persists and adherence to sepsis bundle components in Korea is low, prompting a need for standardized early sepsis treatment.\"},{\"question\":\"How were the guidelines developed?\",\"answer\":\"A de novo method was used, including defining key questions, conducting a literature search and selection, assessing risk of bias, synthesizing evidence, and drafting recommendations using GRADE.\"},{\"question\":\"What early treatments are covered by the recommendations?\",\"answer\":\"Recommendations focus on early interventions such as lactate measurement, fluid therapies, target blood pressure, antibiotic administration, vasopressors and dobutamine, extracorporeal membrane oxygenation, and echocardiography.\"}]","Early management of adult sepsis and septic shock - Korean clinical practice guidelines | PDF",1791162536,580]