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A de novo process used key question definition, literature search and selection, bias assessment, evidence synthesis, and recommendation development. Certainty of evidence and recommendation strength were determined using GRADE. Drafts underwent internal and external review plus public hearings, supported by a research grant.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/early-management-of-adult-sepsis-and-septic-shock-korean-clinical-practice-guidelines-506407/506407/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/early-management-of-adult-sepsis-and-septic-shock-korean-clinical-practice-guidelines-506407/506407.png","ImageObject",300,407,{"name":92,"@type":93},"McQueen","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-10-05",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem do these guidelines target?","Question",{"text":112,"@type":113},"They target low adherence to sepsis bundle components in Korea and persistently high mortality for adult sepsis and septic shock despite advances in recognition and supportive care.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the guidelines developed?",{"text":117,"@type":113},"They used a de novo development method: defining key questions, searching and selecting literature, assessing risk of bias, synthesizing evidence, and forming recommendations with GRADE. 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To address this, the Korean Sepsis Alliance, affiliated with the Korean Society of Critical Care Medicine, developed the first sepsis treatment guidelines for Korea based on a comprehensive systematic review and meta-analysis.  \nMethods: A de novo method was used to develop the guidelines. Methodologies included determining key questions, conducting a literature search and selection, assessing the risk of bias, synthesizing evidence, and developing recommendations. The certainty of evidence and the strength of recommendations were determined using the Grading of Recommendations, Assessment, Development, and Evaluations approach. Draft recommendations underwent internal and external review processes and public hearings. The development of these guidelines was supported by a research grant from the Korean Disease Control and Prevention Agency.  \nResults: In these guidelines, we focused on early treatments for adult patients with sepsis and septic shock. Through the guideline development process, 12 key questions and their respective recommendations were formulated. These include lactate measurement, fluid therapies, target blood pressure, antibiotic administration, use of vasopressors and dobutamine, extracorporeal membrane oxygenation, and echocardiography.  \nConclusions: These guidelines aim to support medical professionals in making appropriate decisions about treating adult sepsis and septic shock. We hope these guidelines will increase awareness of sepsis and reduce its mortality rate.  \nKey Words: guidelines; outcome; sepsis; septic shock; treatment  \nINTRODUCTION  \nSepsis is a life-threatening condition characterized by a dysregulated host response to infection, leading to organ dysfunction. It is a significant global health issue, affecting approximately 50 million individuals annually and causing at least 11 million deaths worldwide [1,2]. In recent decades, advances in sepsis recognition and supportive care have led to improved  \nReview Article  \nReceived: August 3, 2024  \nRevised: September 6, 2024  \nAccepted: September 9, 2024  \nCorresponding author  \nSunghoon Park  \nDepartment of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, 22 Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang 14068, Korea Tel: +82-31-380-3715  \nFax: +82-31-380-3973  \n[Email: f2000tj@gmail.com](Email: f2000tj@gmail.com)  \n©2024 The Korean Society of Critical Care Medicine This is an Open Access article distributed under the terms of Creative Attributions Non-Commercial License ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[li-censes/by-nc/4.0/](li-censes/by-nc/4.0/)) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.  \n[https://www.accjournal.org](https://www.accjournal.org) 1  \nPark C, et al. Management of adult sepsis and septic shock  \noutcomes. However, studies indicate that mortality rates in Korea remain higher than in Western countries, and compliance with sepsis bund","cbCaih2N0MmaH6Yr","https://ap.wps.com/l/cbCaih2N0MmaH6Yr","pdf",1446728,28,"English","# Introduction\n## Methods\n## Results\n## Conclusions","[{\"question\":\"What problem do these guidelines target?\",\"answer\":\"They target low adherence to sepsis bundle components in Korea and persistently high mortality for adult sepsis and septic shock despite advances in recognition and supportive care.\"},{\"question\":\"How were the guidelines developed?\",\"answer\":\"They used a de novo development method: defining key questions, searching and selecting literature, assessing risk of bias, synthesizing evidence, and forming recommendations with GRADE. Drafts were reviewed internally and externally and followed public hearings.\"},{\"question\":\"What early treatment topics are covered?\",\"answer\":\"The recommendations focus on early treatments, including lactate measurement, fluid therapies, target blood pressure, antibiotic administration, vasopressors and dobutamine, extracorporeal membrane oxygenation, and echocardiography.\"}]","Early management of adult sepsis and septic shock: Korean clinical practice guidelines | PDF",1791164781,71]