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This report evaluates an expanded approach using EBUS-guided transbronchial nodal cryobiopsy (EBUS-TBNC) to obtain larger, well-preserved histologic tissue from mediastinal lymph nodes. Four patients underwent combined EBUS-TBNA and EBUS-TBNC under general anesthesia. Two had malignancy and two had benign diseases (silicosis and tuberculosis). In malignant cases, cryobiopsy provided more material for ancillary testing in one patient. In benign cases, results differed between methods; cryobiopsy detected granulomas in the tuberculosis case and improved overall histology in silicosis, enabling definitive diagnosis, with no observed complications.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/early-experience-of-endobronchial-ultrasound-guided-transbronchial-nodal-cryobiopsy-a-case-series-from-sabah-malaysia/326927/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/early-experience-of-endobronchial-ultrasound-guided-transbronchial-nodal-cryobiopsy-a-case-series-from-sabah-malaysia/326927.png","ImageObject",300,407,{"name":92,"@type":93},"Patrick","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What procedure combination was evaluated in this case series?","Question",{"text":112,"@type":113},"The study evaluated combined EBUS-TBNA and EBUS-TBNC for sampling mediastinal lymph nodes in four patients.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did cryobiopsy performance differ between malignant and benign cases?",{"text":117,"@type":113},"In malignant cases, cryobiopsy supported ancillary testing by providing more material in one patient. In benign cases, discordance occurred, and cryobiopsy improved diagnostic histology for tuberculosis and silicosis.",{"name":119,"@type":110,"acceptedAnswer":120},"What conditions were diagnosed among the four patients?",{"text":121,"@type":113},"Two patients were diagnosed with malignancy, while two were diagnosed with benign disorders: silicosis and tuberculosis.",{"name":123,"@type":110,"acceptedAnswer":124},"Were there any reported complications from the procedures?",{"text":125,"@type":113},"No complications were observed in any of the cases.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},326927,1790013030,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":148,"preview_page_count":4},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","Early experience of endobronchial ultrasound-guided transbronchial nodal cryobiopsy: a case series from Sabah, Malaysia  \nHemaYamini Ramarmuty, Nai-Chien Huan, Larry Ellee Nyanti, Teng Shin Khoo, Tamilarasi Renganathan, Ahmad Zaki Manoh, NusaibahAzman and  \nKunji Kannan Sivaraman Kannan  \nTherAdv Respir Dis 2024, Vol. 18: 1–10  \nDOI: 10. 1177/ 17534666241231122 © The Author(s), 2024.  \nArticle reuse guidelines: [sagepub.com/journals](sagepub.com/journals)permissions  \nAbstract: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an established minimally invasive method for the diagnosis of benign and malignant conditions. Continuous efforts are underway to improve the material adequacy of EBUSTBNA, including the introduction of a new technique called EBUS-guided transbronchial nodal cryobiopsy (EBUS-TBNC) . This method allows for the retrieval of larger and wellpreserved histologic samples from the mediastinum. We present a case series of four patients who underwent combined EBUS-TBNA and EBUS-TBNC procedures in our centre. All procedures were performed under general anaesthesia using a convex probe EBUS scope (Pentax EB-1970UK) . Two patients were diagnosed with malignancy and two with benign disorders (silicosis and tuberculosis) . In the malignant cases, both EBUS-TBNA/cell block and cryobiopsy provided a diagnosis but cryobiopsy yielded more material for ancillary tests in one patient. However, in the benign cases, there was discordance between EBUS-TBNA/cell block and cryobiopsy. Only cryobiopsy detected granuloma in the patient with TB (tuberculosis), and in the patient with silicosis, TBNC provided a better overall histological evaluation, leading to a definitive diagnosis. No complications were observed. This case series supports the potential diagnostic value of combining EBUS-TBNA and EBUS-TBNC, particularly in benign mediastinal lesions (granulomatous diseases), and in cases requiring additional molecular tests in cancer diagnosis.  \nPlain language summary  \nExploring a new lymph node biopsy technique: case series from Sabah, Malaysia  \nWe explored a new technique for lung diagnosis called EBUS-guided transbronchial nodal cryobiopsy (EBUS-TBNC) . This method helps get larger and well-preserved tissue samples from the chest area. In our study, we used this technique on four patients alongside the established method called EBUS-guided transbronchial needle aspiration (EBUS-TBNA) . All procedures were done with the patient under general anesthesia using a specific typeof scope. Two patients were found to have cancer, and two had non-cancerous conditions (silicosis and tuberculosis) . In the cancer cases, both methods provided a diagnosis, but the cryobiopsy gave more material for additional tests in one patient. However, in noncancer cases, there were differences between the two methods. Only the cryobiopsy detected granulomas in the tuberculosis patient, and in the silicosis patient, cryobiopsy gave a better overall tissue evaluation, leading to a clear diagnosis. No complications  \nCorrespondence to:  \nHemaYamini Ramarmuty  \nRespiratory Department, Queen Elizabeth Hospital, 13a, Jalan Penampang, Kota Kinabalu, Sabah 88200, Malaysia  \nhemayamini1983@gmail. com  \nNai-Chien Huan Kunji Kannan Sivaraman Kannan  \nRespiratory Department, Queen Elizabeth Hospital, Sabah, Malaysia  \nLarry Ellee Nyanti  \nMedical Department, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Malaysia  \nTeng Shin Khoo  \nMedical Department, Queen Elizabeth Hospital, Sabah, Malaysia  \nTamilarasi Renganathan Ahmad Zaki Manoh Nusaibah Azman  \nDepartment of Pathology, Queen Elizabeth Hospital, Sabah, Malaysia  \n[journals.sagepub.com/home/tar](journals.sagepub.com/home/tar) 1  \nCreative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License  \n([https://creativecommons.org/licenses/by-nc/4.0/](https://creativecommons.org/lice","cbCaigRIR9FrDjEI","https://ap.wps.com/l/cbCaigRIR9FrDjEI","pdf",1203905,"English","# Introduction\n## Procedural steps\n# Results\n## Malignant cases\n## Benign cases\n## Safety and complications\n# Discussion and conclusions","[{\"question\":\"What procedure combination was evaluated in this case series?\",\"answer\":\"The study evaluated combined EBUS-TBNA and EBUS-TBNC for sampling mediastinal lymph nodes in four patients.\"},{\"question\":\"How did cryobiopsy performance differ between malignant and benign cases?\",\"answer\":\"In malignant cases, cryobiopsy supported ancillary testing by providing more material in one patient. In benign cases, discordance occurred, and cryobiopsy improved diagnostic histology for tuberculosis and silicosis.\"},{\"question\":\"What conditions were diagnosed among the four patients?\",\"answer\":\"Two patients were diagnosed with malignancy, while two were diagnosed with benign disorders: silicosis and tuberculosis.\"},{\"question\":\"Were there any reported complications from the procedures?\",\"answer\":\"No complications were observed in any of the cases.\"}]","Early experience of endobronchial ultrasound-guided transbronchial nodal cryobiopsy - a case series from Sabah, Malaysia | PDF",1789975782,25]