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The Angiopoietin–TIE2 axis regulates endothelial function via Ang-1/Ang-2 balance, and elevated Ang-2 with a high Ang-2/1 ratio predicts poor outcomes in critical illness. This prospective study measured serum Ang-1, Ang-2, and Ang-2/1 ratio on postburn day 1 to evaluate endothelial dysfunction biomarkers and 30-day mortality prediction.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/early-dysregulation-of-angiopoietin-1-and-2-as-a-predictor-of-mortality-in-critically-ill-burn-patients/440260/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/early-dysregulation-of-angiopoietin-1-and-2-as-a-predictor-of-mortality-in-critically-ill-burn-patients/440260.png","ImageObject",300,407,{"name":92,"@type":93},"Rainbow Cat","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-07","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the main aim of this study?","Question",{"text":113,"@type":114},"To evaluate Ang-1, Ang-2, and the Ang-2/1 ratio as biomarkers of endothelial dysfunction and as predictors of 30-day mortality in critically ill burn patients.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were Angiopoietin levels measured and when were samples collected?",{"text":118,"@type":114},"Serum Ang-1 and Ang-2 were measured via enzyme-linked immunosorbent assay on postburn day 1.",{"name":120,"@type":111,"acceptedAnswer":121},"Which angiopoietin-related measures were associated with 30-day mortality?",{"text":122,"@type":114},"Non-survivors had lower Ang-1, higher Ang-2, and an elevated Ang-2/1 ratio, and these early levels correlated with 30-day mortality and prognostication.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},440260,1791101984,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962090769181,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","ORIGINAL ARTICLE  \nEarly Dysregulation ofAngiopoietin-1 and-2 as a Predictor of Mortality in Critically Ill Burn Patients  \nRyan M. Johnson, MD1 , 2 , * ; Abigail Plum, MPH2 ; Kevin E. Galicia, MD1 , 2 ;  \nIrena B. Helenowski, PhD2 ; Madison D. Kipp, BS2 ; Mary Grace Murray, BA2 ;  \nRichard Gonzalez, MD1 , 2 ; Mashkoor A. Choudhry, PhD2 ; John C. Kubasiak, MD1 , 2 , *  \nAbstract  \nShock-induced endothelial dysfunction plays a critical role in burn pathophysiology, with endothelial glycocalyx layer degradation promoting systemic inflammation, vascular instability, and multi-organ failure. The angiopoietin-tunica interna endothelial cell kinase (TIE2) axis, particularly the angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) balance, regulates endothelial function; elevated Ang-2 and a high Ang-2/1 ratio are linked to worse outcomes in critical illness. While well-documented in sepsis and trauma, effects of burn-induced angiopoietin dysregulation remain unclear. This study evaluates Ang-1, Ang-2, and the Ang-2/1 ratio as biomarkers of endothelial dysfunction and predictors of 30-day mortality in patients with burn injuries. In this prospective study, 62 adult patients with burn injuries were enrolled (January 2021–November 2024), with serum Ang-1 and Ang-2 measured via  \nenzyme-linked immunosorbent assay on postburn day 1 . Of 62 patients, 52 were analyzed; 78.05% of survivors and 90.91% of non-survivors were male. Median age was 45 (survivors) vs 54 years (non-survivors, P = .139) .  \nNon-survivors trended toward burns > 20% TBSA (72.73% vs 41.46%, P = .093). Ang-1 was lower in non-survivors (3.96 vs 7.97 ng/mL, P \u003C .001), predicting early mortality (area under the receiver operating characteristic [AUROC]: 0.82) with a cut-off of 4.825 ng/mL and decreased mortality risk (odds ratio [OR]: 0.63, 95% confidence interval [CI]: 0.40-0.87, P = .017). Ang-2 was higher (6.07 vs 1.99 ng/mL, P \u003C .001; AUROC: 0.95), with a cut-off of 3.554 ng/mL. The Ang-2/1 ratio was elevated (1.59 vs 0.23, P \u003C .001; AUROC: 0.93), with a cut-off of 0.504 and increased mortality risk (OR: 2.17, 95% CI: 1.10-5.12, P = .038) . Early Ang-1, Ang-2, and Ang-2/1 ratio levels correlate with 30-day mortality and may guide early prognostication.  \nKey words: burn injury; endothelial glycocalyx; endotheliopathy; angiopoietin; prognostic biomarkers.  \nINTRODUCTION  \nPatients with severe burns (>20% of total body surface area [%TBSA]) undergo a profound and sustained immune  \n1 Department of Surgery, Loyola University Medical Center, Maywood, IL 60153, United States; 2 Burn and Shock Trauma Research Institute, Loyola University Chicago, Maywood, IL 60153, United States  \nAuthor contributions: Ryan M. Johnson (Data curation [lead], Formal analysis [equal], Investigation [lead], Supervision [supporting], Validation [equal], Visualization, Writing—original draft, Writing—review & editing [lead]), Abigail Plum (Data curation, Investigation [equal], Validation, Writing—review & editing [supporting]), Kevin E. Galicia (Data curation [supporting], Investigation [equal], Validation, Writing—review & editing [supporting]), Irena B. Helenowski (Data curation, Formal analysis [equal], Validation, Visualization, Writing—review & editing [supporting]), Madison D. Kipp (Data curation, Writing—original draft, Writing—review & editing [supporting]), Mary Grace Murray (Investigation, Validation, Writing—review & editing [supporting]), Richard Gonzalez (Validation, Writing—review & editing [supporting]), MashkoorA. Choudhry (Funding acquisition, Validation, Writing—review & editing [supporting]), and John  \nC. Kubasiak (Conceptualization [lead], Data curation, Formal analysis [supporting], Funding acquisition, Investigation, Methodology, Project  \nadministration, Resources, Software, Supervision [lead], Validation [equal], Visualization, Writing—original draft, Writing—review & editing [supporting])  \nFunding: This work is supported by the National Institute of General Medical Sciences (","cbCaif9MwMsPsefm","https://ap.wps.com/l/cbCaif9MwMsPsefm","pdf",727180,"English","# Abstract\n# Introduction","[{\"question\":\"What was the main aim of this study?\",\"answer\":\"To evaluate Ang-1, Ang-2, and the Ang-2/1 ratio as biomarkers of endothelial dysfunction and as predictors of 30-day mortality in critically ill burn patients.\"},{\"question\":\"How were Angiopoietin levels measured and when were samples collected?\",\"answer\":\"Serum Ang-1 and Ang-2 were measured via enzyme-linked immunosorbent assay on postburn day 1.\"},{\"question\":\"Which angiopoietin-related measures were associated with 30-day mortality?\",\"answer\":\"Non-survivors had lower Ang-1, higher Ang-2, and an elevated Ang-2/1 ratio, and these early levels correlated with 30-day mortality and prognostication.\"}]","Early Dysregulation of Angiopoietin-1 and -2 as a Predictor of Mortality in Critically Ill Burn Patients | PDF",1790691641,25]