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Premalignant lesions such as intraductal papillary mucinous neoplasms and mucinous cystic neoplasms are often visible on imaging, enabling earlier management. PanINs are the most frequent precursors of pancreatic adenocarcinoma, yet they are typically not detectable on radiologic studies. Indirect imaging signs can raise suspicion, leading to serial imaging and blood tests, with resource cost and potential harm. This work reviews possibilities for detecting early malignant lesions before invasion, including cytology of pancreatic juice obtained via nasopancreatic intubation.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/early-detection-of-pancreatic-cancer-editorial/339541/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/early-detection-of-pancreatic-cancer-editorial/339541.png","ImageObject",300,407,{"name":92,"@type":93},"Maeve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is early detection important in pancreatic cancer?","Question",{"text":113,"@type":114},"Early detection of preinvasive stages can improve survival by identifying disease before it becomes invasive and disseminates.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which precursor lesions of pancreatic adenocarcinoma are detectable on imaging?",{"text":118,"@type":114},"Intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas are detectable on imaging studies, supporting earlier management.",{"name":120,"@type":111,"acceptedAnswer":121},"Why are PanINs difficult to detect radiologically?",{"text":122,"@type":114},"PanINs generally cannot be detected on CT or MRI because of their microscopic identity and the lack of characterized associated radiological signs.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},339541,1790303816,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":105},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","| W | J | C | C | World Journal of\u003Cbr>Clinical Cases |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Cases 2024 June 16; 12(17): 2935-2938  \nDOI: 10.12998/wjcc.v12.i17.2935 ISSN 2307-8960 (online)  \nEDITORIAL  \nEarly detection of pancreatic cancer  \nFrancisco J Morera-Ocon  \nSpecialty type: Surgery  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade C  \nNovelty: Grade B  \nCreativity or Innovation: Grade B  \nScientific Significance: Grade B  \nP-Reviewer: Peng XC, China  \nReceived: March 3, 2024  \nRevised: April 24, 2024  \nAccepted: May 11, 2024  \nPublished online: June 16, 2024  \nFrancisco J Morera-Ocon, Department of General Surgery, Hospital General de Requena, Requena 46340, Spain  \nCorresponding author: Francisco J Morera-Ocon, PhD, Doctor, Department of General Surgery, Hospital General de Requena, Paraje Casablanca s/n, Requena 46340, Spain.  \n[fmoreraocon@gmail.com](fmoreraocon@gmail.com)  \nAbstract  \nThe diagnosis of pancreatic cancer associates an appalling significance. Detection of preinvasive stage of pancreatic cancer will ameliorate the survival of this deadly disease. Premalignant lesions such as Intraductal Papillary Mucinous Neoplasms or Mucinous Cystic Neoplasms of the pancreas are detectable on imaging exams and this permits their management prior their invasive development. Pancreatic intraepithelial neoplasms (PanIN) are the most frequent precursors of pancreatic adenocarcinoma (PDAC), and its particular type PanIN high-grade represents the malignant non-invasive form of PDAC. Unfortunately, PanINs are not detectable on radiologic exams. Nevertheless, they can associate indirect imaging signs which would rise the diagnostic suspicion. When this suspicion is established, the patient will be enrolled in a follow-up strategy that includes performing of blood test and serial imaging test such as computed tomography or magnetic resonance imaging, which will cost in the best-case scenario a burden of healthcare systems, and potential mortality in the worst-case scenario when the patient underwent resection surgery, worthless when there is no moderate or high grade dysplasia in the final histopathology. This issue will be avoid having at its disposal a diagnostic technique capable of detecting high-grade PanIN lesions, such is the cytology of pancreatic juice obtained by nasopancreatic intubation. Herein, we review the possibility of detection of early malignant lesions before they become invasive PADC.  \nKey Words: Early pancreatic cancer; Pancreatic adenocarcinoma precursor lesions; Pancreatic juice analysis; PanIN; High-grade pancreatic intraepithelial neoplasm; Magnetic resonance cholangiopancreatography  \n©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJCC  [https://www.wjgnet.com](https://www.wjgnet.com) 2935 June 16, 2024  Volume 12  Issue 17   \nMorera-Ocon FJ. Early detection of pancreatic cancer  \nCore Tip: High-grade pancreatic intraepithelial neoplasia can be diagnosed by cytology of pancreatic juice before they become invasive carcinoma. Candidates to this diagnostic procedure are patients with disturbed anatomy in pancreatic imaging without evident tumor such as segmental atrophy of parenchyma, main pancreatic duct (MPD) stenosis/dilatation, focal blurred MPD or local parenchymal fatty changes.  \nCitation: Morera-Ocon FJ. Early detection of pancreatic cancer. World J Clin Cases 2024; 12(17): 2935-2938  \nURL: [https://www.wjgnet.com/2307-8960/full/v12/i17/2935.htm](https://www.wjgnet.com/2307-8960/full/v12/i17/2935.htm)  \nDOI: [https://dx.doi.org/10.12998/wjcc.v12.i17.2935](https://dx.doi.org/10.12998/wjcc.v12.i17.2935)  \nPancreatic cancer continuous to be a dismal disease. Patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) stage I resectable dise","cbCaig1CMif6RK6k","https://ap.wps.com/l/cbCaig1CMif6RK6k","pdf",2526212,"English","# Editorial\n## Early detection of pancreatic cancer\n## Abstract\n## Core Tip\n## Candidates for cytology-based diagnosis","[{\"question\":\"Why is early detection important in pancreatic cancer?\",\"answer\":\"Early detection of preinvasive stages can improve survival by identifying disease before it becomes invasive and disseminates.\"},{\"question\":\"Which precursor lesions of pancreatic adenocarcinoma are detectable on imaging?\",\"answer\":\"Intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas are detectable on imaging studies, supporting earlier management.\"},{\"question\":\"Why are PanINs difficult to detect radiologically?\",\"answer\":\"PanINs generally cannot be detected on CT or MRI because of their microscopic identity and the lack of characterized associated radiological signs.\"}]","Early detection of pancreatic cancer - Editorial | PDF",1790030918]