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Results show similar loop electrosurgical excision procedure rates and no significant differences in hrHPV persistence, abnormal cytology, or treatment requirements. Conclusion supports risk-based follow-up management.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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is the study’s objective?","Question",{"text":62,"@type":63},"To compare two follow-up strategies and determine whether colposcopy is needed at the initial visit for women with normal Pap cytology but positive for high-risk HPV types other than 16/18, using cytology, HPV testing, and colposcopic findings at 1 year.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How were participants allocated to follow-up strategies?",{"text":67,"@type":63},"A total of 122 women with negative Pap smears and positive high-risk HPV types (not 16/18) were randomly assigned to two groups: early colposcopy at diagnosis or standard Pap/HPV follow-up without initial colposcopy.",{"name":69,"@type":60,"acceptedAnswer":70},"What were the main findings at 1-year follow-up?",{"text":71,"@type":63},"Loop electrosurgical excision procedure rates were similar between groups, and there was no statistically significant difference in high-risk HPV persistence, abnormal cytology rates, or LEEP requirements between early versus delayed assessment.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},351886,1790359608,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & 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colposcopy in non-16/18 high-risk human papillomavirus positivity with normal cytology  \nElif Görkem Bademci1*  , Didem Soysal2 , Mehtap Güneş3  , Ahmet Zengin4   \nSUMMARY  \nOBJECTIVE: Very few clinical studies have been done to evaluate the potential clinical benefit of utilizing early colposcopy in women with normal Pap smear cytology but positive for high-risk human papillomavirus types other than human papillomavirus 16 or human papillomavirus 18 in a screening population for cervical cancer. The aim of this study was to compare two follow-up strategies and assess the need for colposcopy at the initial visit, based on cytology, human papillomavirus testing, and colposcopic findings at 1 year, among study participants.  \nMETHODS: In total, 122 women who had negative Pap smears and were positive for high-risk types of human papillomavirus (not human papillomavirus 16/18) were randomly allocated to two groups via simple computer-generated randomization. Notably, one group had a colposcopic examination when they were first diagnosed (61), and the other group had standard Pap/human papillomavirus follow-up without a colposcopic examination (61) . All women in both groups had repeat Pap and human papillomavirus testing and a colposcopic examination after 1 year.  \nRESULTS: Rates of loop electrosurgical excision procedure application were similar between groups (11.5 and 8.2%; p=0.343). So early colposcopy has enabled the treatment of high-gradesquamous intraepithelial lesion lesions without increasing the number of loop electrosurgical excision procedures. CONCLUSION: In women who had negative cytology yet positive high-risk human papillomavirus types other than human papillomavirus 16/18, there was no statistically significant difference in either high-risk human papillomavirus persistence, abnormal cytology rates, or loop electrosurgical excision procedure requirements at a 1-year follow-up after having their colposcopy performed early vs. delayed assessments. This suggests that these patients can be appropriately managed with risk-based follow-up care.  \nKEYWORDS: Human papillomavirus. Colposcopy. Uterine cervical neoplasms. Papillomavirus infections.  \nINTRODUCTION  \nCervical cancer is one of the deadliest cancers for women globally. Based on GLOBOCAN 2022 data, cervical cancer is the 4th leading cause of cancer in women, with an enormous amount of morbidity and mortality from gynecologic cancers. The annual worldwide incidence of cervical cancer isabout 0.01%1. In Turkey, the incidence of cervical cancer was reported by the General Directorate of Public Health as 4.5 per 100,000 women in 20252. Although there has been a declining trend in the incidence rate of cervical cancer as a result of better access to effective screening programs and increased use of the HPV vaccine in developed nations, cervical cancer remains a significant public health dilemma worldwide, particularly in developing nations.  \nHPV (Human papillomavirus) is primarily responsible for the incidence of cervical cancer. Over 200 types of HPV have been identified worldwide to date; some are called low-risk,  \nwhile others are considered high-risk and can cause cancer. In terms of risk from HPV, there are two principal groups: The two highest-risk types (HPV 16 and HPV 18) have been extensively researched, but many other types in the “HighRisk” category also significantly contribute to the development of cervical cancer, e.g., HPV 31, HPV 33, HPV 35, HPV 39, HPV 45, HPV 51, HPV 52, HPV 56, HPV 58, HPV 59, HPV 66, HPV 68, and HPV 733. The incidence of HPV varies by geographic location, with the highest rates in low-and middle-income regions4. A recent meta-analysis published that included 78 studies of women with normal cytology showed that HPV prevalence is 22.1% in Africa, 20.4% in Central America/Mexico, 11.3% in North America, 8.1% in Europ","cbCaiixbUTM8Qkst","https://ap.wps.com/l/cbCaiixbUTM8Qkst","pdf",203391,"English","# Summary\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What is the study’s objective?\",\"answer\":\"To compare two follow-up strategies and determine whether colposcopy is needed at the initial visit for women with normal Pap cytology but positive for high-risk HPV types other than 16/18, using cytology, HPV testing, and colposcopic findings at 1 year.\"},{\"question\":\"How were participants allocated to follow-up strategies?\",\"answer\":\"A total of 122 women with negative Pap smears and positive high-risk HPV types (not 16/18) were randomly assigned to two groups: early colposcopy at diagnosis or standard Pap/HPV follow-up without initial colposcopy.\"},{\"question\":\"What were the main findings at 1-year follow-up?\",\"answer\":\"Loop electrosurgical excision procedure rates were similar between groups, and there was no statistically significant difference in high-risk HPV persistence, abnormal cytology rates, or LEEP requirements between early versus delayed assessment.\"}]","Early colposcopy in non-16/18 high-risk human papillomavirus positivity with normal cytology | PDF",1790096404,18]