[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-427639-105":59,"doc-detail-427639-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","dysregulation-of-srf-regulated-genes-accelerates-the-development-of-myocardial-aging","Dysregulation of SRF-Regulated Genes Accelerates the Development of Myocardial Aging","","Myocardial aging is linked to structural and functional remodeling that increases vulnerability to heart failure. Serum response factor (SRF), a transcription factor governing cytoskeletal, metabolic, and stress-response genes, is implicated in cardiac homeostasis, with elevated SRF observed in hypertrophy and aging. This study tests whether SRF dysregulation drives myocardial aging by using transgenic mice with mild cardiac SRF overexpression and analyzing echocardiographic, histological, and gene-expression changes.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/dysregulation-of-srf-regulated-genes-accelerates-the-development-of-myocardial-aging/427639/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/dysregulation-of-srf-regulated-genes-accelerates-the-development-of-myocardial-aging/427639.png","ImageObject",300,407,{"name":92,"@type":93},"\tJames","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-20","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What role does SRF play in cardiac homeostasis and aging?","Question",{"text":112,"@type":113},"SRF regulates cytoskeletal, metabolic, and stress-response genes. Increased SRF expression has been observed in cardiac hypertrophy and aging, suggesting a role in maintaining cardiac function.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the effect of SRF dysregulation tested?",{"text":117,"@type":113},"Researchers generated a transgenic mouse model with mild overexpression of the SRF gene in the heart. Echocardiography, histology, quantitative PCR, Western blotting, and bioinformatics analyses of SRF binding sites and pathways were used.",{"name":119,"@type":110,"acceptedAnswer":120},"What metabolic shifts were observed in SRF-dysregulated hearts?",{"text":121,"@type":113},"Over 200 SRF-regulated genes changed significantly in transgenic versus non-transgenic hearts. Fatty acid metabolism, lipid transport, and mitochondrial function were downregulated, while glycolysis-related genes were upregulated, indicating metabolic reprogramming.",{"name":123,"@type":110,"acceptedAnswer":124},"Why does SRF dysregulation matter for cardiac function and therapy?",{"text":125,"@type":113},"The reported gene-expression changes reduced cardiac metabolic efficiency and cardiac function. The study concludes that SRF may be a potential therapeutic target to improve cardiac metabolism and function in aging and pathological conditions.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},427639,1790766475,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":24},2336474466412,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","746 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.2539  \nDYSREGULATION OF SRF-REGULATED GENES  \nACCELERATES THE DEVELOPMENT OF  \nMYOCARDIAL AGING  \nInnovation in Aging, 2025, Vol. 9, No. S2 747  \nXiaomin Zhang1, Gohar Azhar2, Sayed Hasan1, and Jeanne Wei2, 1. University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States, 2. University of Arkansas for Medical Sciences, Little Rock, AR, LITTLE ROCK, Arkansas, United States  \nBackground Myocardial aging is associated with structural and functional changes that increase susceptibility to heart failure. Serum response factor (SRF), a key transcription factor regulating cytoskeletal, metabolic, and stress-response genes, plays a critical role in cardiac homeostasis. An increased expression of SRF has been observed in cardiac hypertrophy and aging. This study aims to investigate the impact of SRF dysregulation on myocardial aging. Methods We generated a transgenic mouse model (Tg) with the mild overexpression of the SRF gene in the heart. The echocardiographic and histological analyses demonstrated that the 6-month-old Tg mice manifested the phenotype of cardiac hypertrophy and aging. We analyzed the cardiac gene expression profile in Tg vs Non-Tg. Quantitative PCR and Western blotting confirmed gene expression. Bioinformatics tools were used to analyze SRF binding sites (CArG and CArG-like motifs) and categorize affected pathways. Results and conclusions Over 200 SRF-regulated genes exhibited significant changes in the Tg versus non-Tg mouse hearts (P \u003C 0.05). These genes are involved in energy metabolism, lipid turnover, cardiac muscle contraction, transcriptional and translational regulation, and stress responses. Notably, the genes critical for fatty acid metabolism, lipid transport and mitochondrial function were downregulated, whereas genes involved in glycolysis were upregulated.  \nTaken together, dysregulation of SRF-regulated genes triggers“metabolic reprogramming”leading to reduced fatty acid metabolism and mitochondrial function, as well as increased glycolysis.  \nThese changes ultimately decrease the cardiac metabolism efficiency and cardiac function. Therefore, SRF is a potential therapeutic target for improving cardiac metabolism and function in aging and pathological conditions.","cbCaidl1X4eRtigg","https://ap.wps.com/l/cbCaidl1X4eRtigg","pdf",1299131,"English","# Background\n# Methods\n# Results and Conclusions\n# Therapeutic Implications","[{\"question\":\"What role does SRF play in cardiac homeostasis and aging?\",\"answer\":\"SRF regulates cytoskeletal, metabolic, and stress-response genes. Increased SRF expression has been observed in cardiac hypertrophy and aging, suggesting a role in maintaining cardiac function.\"},{\"question\":\"How was the effect of SRF dysregulation tested?\",\"answer\":\"Researchers generated a transgenic mouse model with mild overexpression of the SRF gene in the heart. Echocardiography, histology, quantitative PCR, Western blotting, and bioinformatics analyses of SRF binding sites and pathways were used.\"},{\"question\":\"What metabolic shifts were observed in SRF-dysregulated hearts?\",\"answer\":\"Over 200 SRF-regulated genes changed significantly in transgenic versus non-transgenic hearts. Fatty acid metabolism, lipid transport, and mitochondrial function were downregulated, while glycolysis-related genes were upregulated, indicating metabolic reprogramming.\"},{\"question\":\"Why does SRF dysregulation matter for cardiac function and therapy?\",\"answer\":\"The reported gene-expression changes reduced cardiac metabolic efficiency and cardiac function. The study concludes that SRF may be a potential therapeutic target to improve cardiac metabolism and function in aging and pathological conditions.\"}]","Dysregulation of SRF-Regulated Genes Accelerates the Development of Myocardial Aging | PDF",1790644433]