[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-208897-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-208897-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","dysphonia-as-a-sign-of-hpv-laryngeal-infection-a-case-report","Dysphonia as a Sign of HPV Laryngeal Infection - A Case Report","","Voice dysfunction and dysphonia can arise from diverse clinical conditions, including benign lesions caused by human papillomavirus (HPV). This case report documents dysphonia in a patient presenting with an HPV-induced laryngeal lesion, with emphasis on clinical manifestations, histopathological findings, and management. Video-laryngostroboscopy and excision of the vocal fold lesion were followed by pathological confirmation of squamous papilloma without malignancy. Follow-up highlights the role of HPV genotyping to assess recurrence risk.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/dysphonia-as-a-sign-of-hpv-laryngeal-infection-a-case-report/208897/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/dysphonia-as-a-sign-of-hpv-laryngeal-infection-a-case-report/208897.png","ImageObject",300,407,{"name":42,"@type":43},"Hazel","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-22","2026-09-05",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What condition does the case report focus on?","Question",{"text":63,"@type":64},"The report focuses on dysphonia as a sign of HPV-induced laryngeal infection, presenting as laryngeal papilloma.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was the laryngeal lesion evaluated and confirmed?",{"text":68,"@type":64},"Video-laryngostroboscopy showed laryngeal findings, excision was performed, and histopathology confirmed squamous papilloma without malignancy.",{"name":70,"@type":61,"acceptedAnswer":71},"Why is HPV genotyping important in follow-up?",{"text":72,"@type":64},"Diagnostic confirmation by HPV genotyping supports follow-up planning by helping monitor the risk of potential recurrence.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},208897,1788607006,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":30,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":80,"read_time":111},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","Longubuco et al. BMC Research Notes 2014, 7:898 [http://www.biomedcentral.com/1756-0500/7/898](http://www.biomedcentral.com/1756-0500/7/898)  \nCASE REPORT Open Access   \nDysphonia as a sign of HPV laryngeal infection: a case report  \nCarlos Eduardo Gama Longubuco 1, Helena Lucia Barroso dos Reis2*, Fernanda Sampaio Cavalcante3, Carla Renata Petillo de Pinho4, Nathalia Silva Oliveira5, Alcina Frederica Nicol5, Renata Quintella Zamolyi6 and Dennis de Carvalho Ferreira3,4,7,8  \nAbstract  \nBackground: Voice dysfunction or dysphonia may be associated with several clinical conditions. Among these, laryngeal human papillomavirus (HPV)-induced lesions should be considered as a possible causative factor. Wereport a case of dysphonia in a patient presenting with an HPV laryngeal lesion. We also discuss the clinical features of the disease, its histopathological findings, and treatment and rigorous follow-up.  \nCase presentation: We report a case of laryngeal papilloma in a 29-year-old, Afro-descendant, male patient with dysphonia. He was a non-smoker and was not a drug user. Videolaryngostroboscopy revealed signs suggestive of pharyngolaryngeal reflux. The right vocal fold presented with a papillomatous aspect in the posterior third, which underwent excision. Histopathological examination showed a nodular lesion of the right vocal fold, conclusive ofsquamous papilloma with absence of malignancy.  \nConclusion: Patients presenting with persistent voice dysfunction or dysphonia should be investigated for possible laryngeal HPV infection. Diagnostic confirmation by HPV genotyping is important for follow-up of potential recurrence. Keywords: Dysphonia, Human papillomavirus, Vocal fold  \nBackground  \nVoice dysfunction or dysphonia has widespread effects and has been frequently studied. Functional and neoplastic dysphonia is among the many causative factors; however, it may also be associated with neurological and systemic diseases, as well as other diseases such as oropharyngeal papilloma, which is a benign tumor caused by human papillomavirus (HPV). More than 200 HPV types have been described and 40 are capable of infecting the anogenital and oral epithelia. HPV may be clinically characterized by appearing in proliferative processes such as oral papilloma, commonly associated with low-risk genotypes 6 and 11. It has also been considered as the major etiological agent in development of neoplasia of the anogenital tract, such as cervical, anal, and penile cancer, as well as oral tumors, where there is a higher prevalence of high-risk genotypes 16 and 18 [1].  \n* Correspondence: [dr.hbarroso@gmail.com](dr.hbarroso@gmail.com)  \n2Ginecology and Obstetrics Outpatient Care, Federal University of Espírito Santo (UFES), Vitória, Brazil  \nFull list of author information is available at the end of the article  \nThe World Health Organization (WHO) considers HPV infection to be an epidemic of high relevance for public health [2].  \nThe most frequently observed oral manifestations associated with HPV infection there include: condyloma acuminatum, focal epithelial hyperplasia, verruca vulgaris, and oral squamous papilloma. These lesions are all benign and are normally associated with infection with low-risk HPVs, among which subtypes 6 and 11 are more prevalent [3,4].  \nHPV infection may also be associated with oropharyngeal carcinoma development, among which, squamous cell carcinoma is the eighth most common type of cancer in men. Additionally, persistent virus infection, together with the use of alcohol and tobacco are predisposing factors for development of oropharyngeal cancer [3,5].  \nOne of the main complaints with these types of lesions is speech alteration (dysphonia), as reported in the present case, and deglutition (dysphagia) [6]. Ximenes Filho et al. have reported laryngeal papillomatosis, and 54.54% of patients presented with dysphonia, and 4.54% with dysphagia and bleeding [6].  \n© 2014 Longubuco et al.; licensee BioMed Central. This is an Op","cbCaifeu4kxku6sa","https://ap.wps.com/l/cbCaifeu4kxku6sa","pdf",963583,"English","# Abstract\n## Background\n## Case presentation\n## Conclusion\n# Background\n## HPV infection and oral manifestations\n## Laryngeal disease and dysphonia\n# Case presentation\n## Patient history and clinical findings","[{\"question\":\"What condition does the case report focus on?\",\"answer\":\"The report focuses on dysphonia as a sign of HPV-induced laryngeal infection, presenting as laryngeal papilloma.\"},{\"question\":\"How was the laryngeal lesion evaluated and confirmed?\",\"answer\":\"Video-laryngostroboscopy showed laryngeal findings, excision was performed, and histopathology confirmed squamous papilloma without malignancy.\"},{\"question\":\"Why is HPV genotyping important in follow-up?\",\"answer\":\"Diagnostic confirmation by HPV genotyping supports follow-up planning by helping monitor the risk of potential recurrence.\"}]","Dysphonia as a Sign of HPV Laryngeal Infection - A Case Report | PDF"]