[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332945-105":59,"doc-detail-332945-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","dynamics-in-the-prostate-immune-microenvironment-induced-by-androgen-deprivation-therapy","Dynamics in the Prostate Immune Microenvironment Induced by Androgen Deprivation Therapy","","This study investigates how testosterone influences the prostate immune microenvironment and how these dynamics change after androgen deprivation therapy (ADT). Using retrospective comparisons of paired prostate needle biopsy and radical prostatectomy specimens from 33 patients receiving neoadjuvant ADT, immune-cell infiltration was quantified by multiplex fluorescence immunohistochemistry. After ADT, immune cells in prostatectomy specimens significantly increased, while the same patients’ biopsies showed few detectable cells. CD20+ B cells decreased in cancer areas of high-risk NCCN cases and this difference related to Gleason Grade Group rather than PSA or T stage, with no recurrence-rate differences across grade groups.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/dynamics-in-the-prostate-immune-microenvironment-induced-by-androgen-deprivation-therapy/332945/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/dynamics-in-the-prostate-immune-microenvironment-induced-by-androgen-deprivation-therapy/332945.png","ImageObject",300,407,{"name":92,"@type":93},"Theodora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s main goal regarding the prostate immune microenvironment?","Question",{"text":112,"@type":113},"To clarify the dynamics of immune cells in the prostate after androgen deprivation therapy (ADT), especially in relation to testosterone’s influence on immune microenvironment behavior.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were immune cells evaluated after ADT in the study?",{"text":117,"@type":113},"Immune-cell infiltration in cancer and stroma areas was assessed using multiplex fluorescence immunohistochemistry on paired biopsy and radical prostatectomy specimens from the same 33 patients.",{"name":119,"@type":110,"acceptedAnswer":120},"What key immune-cell changes were observed after ADT, and how did biopsy compare to prostatectomy?",{"text":121,"@type":113},"Post-ADT, all immune cell types assessed significantly increased in prostatectomy specimens, whereas few immune cells were detected in the corresponding biopsy samples from the same patients (p \u003C 0.001).","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332945,1790012847,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},687197207919,"https://ap-avatar.wpscdn.com/avatar/a000253d6f5f7c60be?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779446848396160552","The Prostate  \nORIGINAL ARTICLE   \nDynamics in the Prostate Immune Microenvironment Induced by Androgen Deprivation Therapy  \nYoshinori Yanai1,2 | Takeo Kosaka1  | Shuji Mikami3,4 | Masashi Arai1 | Keitaro Watanabe1 | Toshikazu Takeda1 | Kazuhiro Matsumoto1  | Makiko Yamashita5 | Shigehisa Kitano2,5 | Mototsugu Oya1  \n1Department of Urology, Keio University School of Medicine, Tokyo, Japan | 2Division of Clinical Chemotherapy, The Cancer Chemotherapy Center of Japanese Foundation for Cancer Research, Tokyo, Japan | 3Department of Diagnostic Pathology, National Hospital Organization Saitama Hospital, Saitama, Japan | 4Department of Diagnostic Pathology, Keio University School of Medicine, Tokyo, Japan | 5Department of Advanced Medical Development, The  \nCancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan Correspondence: Takeo Kosaka ([takemduro@gmail.com](takemduro@gmail.com))  \nReceived: 4 October 2024 | Revised: 4 November 2024 | Accepted: 8 November 2024  \nFunding: This work was supported in part by a Grant‐in‐Aid for Scientific Research (\\#20H03817 to T.K.) from the Ministry of Education, Culture, Sports, Science and Technology of Japan and a research grant to T.K. from the Japan Urological Association Research Grant.  \nKeywords: androgen deprivation therapy | dynamics | immune cell | microenvironment | prostate  \nABSTRACT  \nBackground: The influence of testosterone on the prostate's immune microenvironment remains unclear. This study aims to elucidate the dynamics of immune cells in the prostate following androgen deprivation therapy (ADT) .  \nMethods: We retrospectively compared prostate needle biopsy and radical prostatectomy specimens from 33 patients who underwent both procedures, along with neoadjuvant ADT at a single institution. Immune cell infiltration in the cancer and stroma areas was assessed using multiplex fluorescence immunohistochemistry.  \nResults: Post‐ADT, all immune cells, including CD4+ T cells, CD8+ T cells, Foxp3+ regulatory T cells, CD204+ macrophages, and CD20+ B cells, significantly increased in the prostatectomy specimen. However, few immune cells were detected in the biopsy of the same patients (p \u003C 0 .001) . The number of CD20+ B cells in the cancer area was significantly lower post‐ADT in high‐risk cases according to the NCCN classification (p = 0.020) . This difference was significantly associated with the Gleason Grade Group, rather than PSA levels or T classification (p \u003C 0.001) . However, no significant difference was observed in the recurrence rate between Grade Groups 1, 2, 3 and 4, 5 (p = 0.991) . There was no significant difference in immune cells other than CD20+ B cells when divided into NCCN classifications.  \nConclusions: The marked increase in immune cells following ADT suggests an intensified immune response against prostate cancer.  \n1 | Introduction  \nThe incidence of prostate cancer is strongly correlated with age, with the highest rates observed in older men [1]. Testosterone, a primary male hormone, exhibits variability in both its production and physiological effects across individuals. The relationship between testosterone and the immune system is multifaceted, involving several interconnected pathways. Testosterone profoundly influences male immune function and is generally believed  \nto suppress the immune system [2, 3]. It serves as a key regulator of neutrophil function and curtails the reproduction of proinflammatory cytokines [4]. However, testosterone does not merely suppress the immune system but has various effects. It is important to fully understand how these relationships influence the individual's circumstances and diseases.  \nThe immune system plays a crucial role in cancer's onset and progression [5, 6] . It can be affected when androgen levels  \nThis is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the or","cbCait9pnXom3sep","https://ap.wps.com/l/cbCait9pnXom3sep","pdf",4645658,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions","[{\"question\":\"What was the study’s main goal regarding the prostate immune microenvironment?\",\"answer\":\"To clarify the dynamics of immune cells in the prostate after androgen deprivation therapy (ADT), especially in relation to testosterone’s influence on immune microenvironment behavior.\"},{\"question\":\"How were immune cells evaluated after ADT in the study?\",\"answer\":\"Immune-cell infiltration in cancer and stroma areas was assessed using multiplex fluorescence immunohistochemistry on paired biopsy and radical prostatectomy specimens from the same 33 patients.\"},{\"question\":\"What key immune-cell changes were observed after ADT, and how did biopsy compare to prostatectomy?\",\"answer\":\"Post-ADT, all immune cell types assessed significantly increased in prostatectomy specimens, whereas few immune cells were detected in the corresponding biopsy samples from the same patients (p \\u003c 0.001).\"}]","Dynamics in the Prostate Immune Microenvironment Induced by Androgen Deprivation Therapy | PDF",1790000087,18]