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Prior in vitro and in vivo studies suggest dutasteride can induce PSMA expression. This pilot study evaluated short-term oral dutasteride on PSMA PET/MRI standardized uptake values (SUVmax) and PSMA immunohistochemical expression in four patients, comparing pre- and post-treatment findings.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/dutasteride-treatment-and-its-effect-on-standardized-uptake-values-in-prostate-specific-membrane-antigen-pet-imaging-a-pilot-study/352879/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/dutasteride-treatment-and-its-effect-on-standardized-uptake-values-in-prostate-specific-membrane-antigen-pet-imaging-a-pilot-study/352879.png","ImageObject",300,407,{"name":92,"@type":93},"Aditya","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the primary goal of this pilot study?","Question",{"text":113,"@type":114},"To assess how short-term dutasteride treatment affects PSMA PET imaging standardized uptake values (SUVmax) and PSMA immunohistochemical expression in humans.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was dutasteride administered, and for how long?",{"text":118,"@type":114},"All patients received 0.5 mg oral dutasteride once daily for seven days before the second PSMA PET/MRI and template biopsy.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the main imaging and biopsy findings?",{"text":122,"@type":114},"SUVmax increased in all patients after short-term dutasteride. Histology confirmed prostate cancer (ISUP grade ≥ 2) in PSMA-positive lesions with increased SUVmax, while one PSMA-positive lesion with decreased SUVmax was negative for cancer on biopsy.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},352879,1790797351,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":41},962085564549,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","OPEN ACCESS  \nCitation: Praetzel L, Burger IA, Rüschoff JH, Rupp NJ, Eberli D, Kranzbühler B (2026) Dutasteride treatment and its effect on standardized uptake values in prostate-specific membrane antigen-PET imaging: A pilot  \nstudy. PLoS One 21(5): e0348695. [https://doi](https://doi). org/10.1371/journal.pone.0348695  \nEditor: Matteo Bauckneht, IRCCS Ospedale Policlinico San Martino, Genova, Italy, ITALY Received: February 18, 2026  \nAccepted: April 20, 2026  \nPublished: May 6, 2026  \nPeer Review History: PLOS recognizes the benefits of transparency in the peer review process; therefore, we enable the publication of all of the content of peer review and author responses alongside final, published articles. The editorial history of this article is available here: [https://doi.org/10.1371/journal](https://doi.org/10.1371/journal). pone.0348695  \nCopyright: © 2026 Praetzel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution,  \nRESEARCH ARTICLE  \nDutasteride treatment and its effect on standardized uptake values in prostate-specific membrane antigen-PET imaging: A pilot study  \nLucas Praetzel1, Irene A. Burger2,3,4, Jan H. Rüschoff5, Niels J. Rupp5, Daniel Eberli1, Benedikt Kranzbühler1*  \n1 Department of Urology, University Hospital of Zurich, Zürich, Switzerland, 2 Department of Nuclear Medicine, University Hospital of Zurich, Zürich, Switzerland, 3 Department of Nuclear Medicine, Cantonal Hospital Baden, University of Zurich, Baden, Switzerland, 4 Department of Health Sciences and Technology, Federal Institute of Technology Zurich, Zurich, Switzerland, 5 Department of Pathology, University Hospital of Zurich, Zürich, Switzerland  \n* [b.kranzbuehler@me.com](b.kranzbuehler@me.com)  \nAbstract  \nBackground  \nProstate-specific membrane antigen (PSMA)-based imaging has become an increasingly important diagnostic tool in prostate cancer, though limited by low surface expression of PSMA in some patients. Previous studies have demonstrated that dutasteride can induce PSMA expression in vitro and in vivo. This pilot study aimed to evaluate the impact of short-term dutasteride treatment on standardized uptake values (SUVmax) in PSMA PET imaging and the immunohistochemical expression of PSMA for the first time in humans.  \nMethods  \nFour prostate cancer (PCa) patients underwent an initial PSMA PET/MRI of the prostate. Afterwards, all patients received 0.5 mg of oral dutasteride once daily for seven days. Subsequently, a second PSMA PET/MRI of the prostate and a template biopsy were performed. We compared the maximum standardized uptake value (SUVmax) of PSMA-positive lesions before and after dutasteride treatment. Additionally, histopathological specimens from PSMA-positive lesions and negative controls were analyzed for Gleason score and PSMA expression.  \nResults  \nAn increase in SUVmax was observed in all patients following short-term dutasteride treatment. Histological analysis confirmed prostate cancer with an ISUP grade of ≥ 2 in PSMA-positive lesions that exhibited increased SUVmax following short-term stimulation. One PSMA-positive lesion, which showed a decrease in SUVmax after stimulation, was negative for prostate cancer on biopsy.  \nPLOS One | [https://doi.org/10.1371/journal.pone.0348695](https://doi.org/10.1371/journal.pone.0348695) May 6, 2026 1 / 12  \nand reproduction in any medium, provided the original author and source are credited.  \nData availability statement: All relevant data are within the manuscript.  \nFunding: The author(s) received no specific funding for this work.  \nCompeting interests: There are no competing interests.  \nConclusion  \nThis pilot study demonstrated an increase in SUVmax in PSMA-positive prostate cancer lesions following a short-term seven-day course of dutasteride. Short-term dutasteride treatment prior to PSMA-PET imaging may have the potential to enhance detection rates in patients with ","cbCaimBL3LTOFzJQ","https://ap.wps.com/l/cbCaimBL3LTOFzJQ","pdf",1008050,12,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Materials and method","[{\"question\":\"What was the primary goal of this pilot study?\",\"answer\":\"To assess how short-term dutasteride treatment affects PSMA PET imaging standardized uptake values (SUVmax) and PSMA immunohistochemical expression in humans.\"},{\"question\":\"How was dutasteride administered, and for how long?\",\"answer\":\"All patients received 0.5 mg oral dutasteride once daily for seven days before the second PSMA PET/MRI and template biopsy.\"},{\"question\":\"What were the main imaging and biopsy findings?\",\"answer\":\"SUVmax increased in all patients after short-term dutasteride. Histology confirmed prostate cancer (ISUP grade ≥ 2) in PSMA-positive lesions with increased SUVmax, while one PSMA-positive lesion with decreased SUVmax was negative for cancer on biopsy.\"}]","Dutasteride treatment and its effect on standardized uptake values in prostate-specific membrane antigen-PET imaging: A pilot study | PDF",1790101837]