[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-150673-en":3,"doc-seo-150673-105":29,"detail-sidebar-cat-0-en-105":89},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":4,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":20,"language":21,"language_code":22,"site_id":23,"html_lang":22,"table_of_contents":24,"faqs":25,"seo_title":26,"seo_description":14,"update_tm":27,"read_time":28},150673,19241457091524,"Gelato","https://us-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c",7,"Healthcare","DUROLANE 3 mL IFU (BR) - Instruções de uso","DUROLANE is a sterile, transparent viscoelastic hyaluronic acid gel for single-use intra-articular injection. It is intended for symptomatic treatment of mild to moderate knee or hip osteoarthritis, administered by an authorized physician in accordance with local legislation. Each mL contains 20 mg stabilized nonanimal hyaluronic acid in buffered physiological sodium chloride solution pH 7. The product restores joint viscosity and elasticity to help reduce pain and improve mobility, with a recommended dose of 3 mL injected once per treatment course for the affected knee or hip.","INSTRUCTIONS FOR USE Contents  \nEach mL contains:  \nHyaluronic acid stabilized 20 mg  \nPhys sodium chloride solution, pH7 q.s.  \nDescription  \nDUROLANE* is intended to be used for intra-articular injection for the symptomatic treatment of mild to moderate knee or hip osteoarthritis. It should be injected by an authorized physician, or in accordance with local legislation.  \nDUROLANE contains 20 mg/mL of stabilized nonanimal hyaluronic acid in buffered physiological sodium chloride solution pH 7. DUROLANE is a sterile, transparent viscoelastic gel supplied in a 3 mL glass syringe, see Figure 1 schematic drawing of the filled syringe. The product is for single use only.  \nHyaluronic acid is identical in all living organisms. It is a natural polysaccharide that is present throughout the tissues ofthe body, with particularly high concentrations in the synovial fluid and the skin. DUROLANE is composed of biosynthetically produced hyaluronic acid which has been purified and stabilized. DUROLANE is degraded in the body by the same metabolic pathway as endogenous hyaluronic acid.  \nMode of Action  \nThe body’s hyaluronic acid constitutes a natural part of the synovial fluid and acts in the joints both as a lubricant of cartilage and ligaments and as a shock absorber. Injections of hyaluronic acid in the joint to restore the viscosity and elasticity can diminish the pain and improve the mobility of the joint.  \nDosage  \nDUROLANE is a single injection , single dose preparation and should only be injected once per treatment course. The recommended dose is 3 mL per knee or hip joint.  \nINSTRUÇÕES DE USO Conteúdo  \nCada mL contém:  \nÁcido hialurônico estabilizado 20 mg  \nSolução fisiológica de cloreto de sódio, pH7 q.s.  \nDescrição  \nO DUROLANE* destina-se ao uso como injeção intra-articular para o tratamento sintomático deosteoartrite ou osteoartrose leve à moderada do joelho ou do quadril. Ele deve ser injetado por ummédico autorizado ou em conformidade com alegislação local.  \nO DUROLANE contém 20 mg/mL de ácido hialurônico não animal estabilizado em soluçãofisiológica tamponada de cloreto de sódio compH 7. O DUROLANE é um gel viscoelástico estérile transparente fornecido em uma seringa de vidrode 3 mL, ver na Figura 1 desenho esquemático daseringa preenchida. O produto é indicado apenas para uma única utilização.  \nO ácido hialurônico é idêntico em todos os organismos vivos. Ele é um polissacarídeo natural presenteem todos os tecidos do corpo, com concentrações particularmente elevadas no fluido sinovial e na pele. O DUROLANE é composto de ácido hialurônico biossinteticamente produzido, que foi purificado eestabilizado. O DUROLANE é degradado no corpopela mesma via metabólica do ácido hialurônico endógeno.  \nModo de ação  \nO ácido hialurônico do corpo constitui uma parte natural do fluido sinovial e age nas articulações como lubrificante de cartilagem e ligamentos e como amortecedor. As injeções de ácido hialurônico na articulação para restaura r a viscosidadee a elasticidade podem reduzir a dor e melhorara mobilidade da articulação.  \nDosagem  \nO DUROLANE é uma preparação de dose única e injeção única e deve ser injetado apenas uma vez por curso de tratamento. A dose recomendada é de 3 mL por cada articulação do joelho ou quadril.  \nIndications  \nSymptomatic treatment of mild to moderate knee or hip osteoarthritis.  \nContraindications  \nNone known.  \nWarnings  \n• DUROLANE should not be injected if the synovial joint is infected or severely inflamed.  \n• DUROLANE should not be injected if there is an active skin disease or infection present at or near the injection site.  \n• DUROLANE should not be injected intravascularly or extra-articularly or in the synovial tissues or capsule.  \n• Do not resterilize DUROLANE as this may damage the product.  \nPrecautions  \n• DUROLANE should be used with caution in patients with venous or lymphatic stasis present in the leg.  \n• DUROLANE has not been tested in pregnant or lactating women or in childre","cbCairBSlr0uXltz","https://ap.wps.com/l/cbCairBSlr0uXltz","pdf",751012,1,"English","en",105,"# Contents\n## Description\n## Mode of Action\n## Dosage\n## Indications\n## Contraindications\n## Warnings\n## Precautions","[{\"question\":\"What conditions is DUROLANE indicated for?\",\"answer\":\"DUROLANE is indicated for symptomatic treatment of mild to moderate knee or hip osteoarthritis.\"},{\"question\":\"How is DUROLANE dosed and how many injections are used per course?\",\"answer\":\"DUROLANE is a single injection, single dose preparation. The recommended dose is 3 mL per knee or hip joint, injected only once per treatment course.\"},{\"question\":\"When should DUROLANE not be injected?\",\"answer\":\"Do not inject DUROLANE if the synovial joint is infected or severely inflamed, if there is active skin disease or infection near the injection site, or if injection would be intravascular, extra-articular, or into synovial tissues or the capsule.\"}]","DUROLANE 3 mL IFU (BR) - Instruções de uso | PDF",1787825336,3,{"code":4,"msg":30,"data":31},"ok",{"site_id":23,"language":22,"slug":32,"title":13,"keywords":33,"description":14,"schema_data":34,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":27},"durolane-3-ml-ifu-br-instructions-for-use","",{"@graph":35,"@context":83},[36,52,66],{"@type":37,"itemListElement":38},"BreadcrumbList",[39,43,47,49],{"item":40,"name":41,"@type":42,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":44,"name":45,"@type":42,"position":46},"https://docshare.wps.com/document/","Document",2,{"item":48,"name":12,"@type":42,"position":28},"https://docshare.wps.com/document/healthcare/",{"item":50,"name":13,"@type":42,"position":51},"https://docshare.wps.com/document/durolane-3-ml-ifu-br-instructions-for-use/150673/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"inLanguage":22,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":40,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-08-27",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What conditions is DUROLANE indicated for?","Question",{"text":73,"@type":74},"DUROLANE is indicated for symptomatic treatment of mild to moderate knee or hip osteoarthritis.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"How is DUROLANE dosed and how many injections are used per course?",{"text":78,"@type":74},"DUROLANE is a single injection, single dose preparation. The recommended dose is 3 mL per knee or hip joint, injected only once per treatment course.",{"name":80,"@type":71,"acceptedAnswer":81},"When should DUROLANE not be injected?",{"text":82,"@type":74},"Do not inject DUROLANE if the synovial joint is infected or severely inflamed, if there is active skin disease or infection near the injection site, or if injection would be intravascular, extra-articular, or into synovial tissues or the capsule.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":23},{"code":4,"msg":5,"data":90},[91,95,99,103,108,113,116,121,126,129,133],{"id":20,"doc_module":4,"doc_module_name":45,"category_name":92,"show_sort_weight":93,"slug":94},"Story & Novel",90,"story-novel",{"id":46,"doc_module":4,"doc_module_name":45,"category_name":96,"show_sort_weight":97,"slug":98},"Literature",80,"literature",{"id":51,"doc_module":4,"doc_module_name":45,"category_name":100,"show_sort_weight":101,"slug":102},"Exam",70,"exam",{"id":104,"doc_module":4,"doc_module_name":45,"category_name":105,"show_sort_weight":106,"slug":107},5,"Comic",60,"comic",{"id":109,"doc_module":4,"doc_module_name":45,"category_name":110,"show_sort_weight":111,"slug":112},6,"Technology",50,"technology",{"id":11,"doc_module":4,"doc_module_name":45,"category_name":12,"show_sort_weight":114,"slug":115},40,"healthcare",{"id":117,"doc_module":4,"doc_module_name":45,"category_name":118,"show_sort_weight":119,"slug":120},8,"Research & Report",30,"research-report",{"id":122,"doc_module":4,"doc_module_name":45,"category_name":123,"show_sort_weight":124,"slug":125},9,"Religion & Spirituality",20,"religion-spirituality",{"id":124,"doc_module":4,"doc_module_name":45,"category_name":127,"show_sort_weight":124,"slug":128},"World Cup","world-cup",{"id":130,"doc_module":4,"doc_module_name":45,"category_name":131,"show_sort_weight":130,"slug":132},10,"Lifestyle","lifestyle",{"id":134,"doc_module":4,"doc_module_name":45,"category_name":135,"show_sort_weight":104,"slug":136},19,"General","general"]