[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-443047-105":59,"doc-detail-443047-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","dural-closure-method-using-dural-suture-and-polyglycolic-acid-nonwoven-fabric-in-the-endoscopic-endonasal-approach","Dural Closure Method Using Dural Suture and Polyglycolic Acid Nonwoven Fabric in the Endoscopic Endonasal Approach","","The study evaluates a dural closure strategy for skull base reconstruction during the endoscopic endonasal approach (EEA) for sellar and parasellar tumors, where cerebrospinal fluid (CSF) leakage risk increases as surgical indications expand. A polyglycolic acid (PGA) nonwoven fabric with dural suturing (S-PGA) was assessed after lesion resection, compared with earlier fat-based reconstructions. Among 325 cases, postoperative CSF leakage occurred in 0.8% with S-PGA versus 5.2% with fat filling, showing significant reduction.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/dural-closure-method-using-dural-suture-and-polyglycolic-acid-nonwoven-fabric-in-the-endoscopic-endonasal-approach/443047/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/dural-closure-method-using-dural-suture-and-polyglycolic-acid-nonwoven-fabric-in-the-endoscopic-endonasal-approach/443047.png","ImageObject",300,407,{"name":92,"@type":93},"moss~","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-02","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What surgical problem does the dural closure method aim to address?","Question",{"text":112,"@type":113},"It targets prevention of postoperative cerebrospinal fluid (CSF) leakage during endoscopic endonasal approach procedures for sellar and parasellar lesions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the S-PGA method differ from the earlier fat-filling approach?",{"text":117,"@type":113},"S-PGA uses dural sutures with a polyglycolic acid (PGA) nonwoven fabric, while the fat-filling method relies on fat graft-based reconstruction with fibrin glue after fat filling.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key outcome results regarding postoperative CSF leakage?",{"text":121,"@type":113},"Postoperative CSF leakage was 0.8% for the S-PGA method and 5.2% for the fat-filling method, indicating a significant improvement (P \u003C 0.01).","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},443047,1790912665,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962090895452,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Accepted Manuscript online: 2024-11-07 Article published online: 2024-11-29  \nOriginal Article 57  \nDural Closure Method Using Dural Suture and Polyglycolic Acid Nonwoven Fabric in the Endoscopic Endonasal Approach  \nDaisuke Tanioka 1 Ikuya Natori 1 Yusuke Kobayashi 1 Katsuyoshi Shimizu 1 Tohru Mizutani 1  \n1 Department of Neurosurgery, Showa University School of Medicine, Tokyo, Japan  \nJ Neurol Surg B Skull Base 2026;87:57–62.  \nAddress for correspondence Daisuke Tanioka, MD, PhD, Department of Neurosurgery, Showa University School of Medicine, Tokyo 142-8555, Japan (e-mail: [tanitani@qk9.so-net. ne.jp](tanitani@qk9.so-net. ne.jp)).  \nAbstract  \nKeywords  \n► polyglycolic acid nonwoven fabric  \n► dural suture  \n► endoscopic endonasal approach  \n► cerebrospinal fluid leakage  \n► reconstruction of skull base  \nIntroduction The indications for surgery using the endoscopic endonasal approach (EEA) for tumors in the sella turcica and parasellar region are expanding. However, the risk of cerebrospinal fluid (CSF) leakage is also increasing. Therefore, to prevent postoperative CSF leakage, it is essential to use safe reconstruction methods for thesella turcica. A polyglycolic acid (PGA) nonwoven fabric is applied during dural reconstruction in neurosurgery. Nevertheless, its suitability for sella turcica reconstruction has not been validated.  \nMethods This study enrolled patients who underwent lesion resection using EEA, followed by sella turcica reconstruction using the dural closure method and the simple and robust suture and PGA (S-PGA) method. The outcomes of the surgery were compared with those of fat-based reconstructive procedures performed prior to the introduction of the S-PGA method.  \nResults In total, 325 patients underwent dural closure using the S-PGA method. The incidence rates of postoperative CSF leakage were 0.8% for the S-PGA method and 5.2% for the fat-filling method. This finding indicated significant improvement in the incidence rates of postoperative CSF leakage (P \u003C 0.01) . The S-PGA method did not affect radiogram interpretation of magnetic resonance imaging performed at 3 months after surgery due to the absence of intrasellar fat filling.  \nConclusion The S-PGA method in EEA is a simple and reliable technique for decreasing the risk of postoperative CSF leakage to the greatest extent possible. Hence, it can be an excellent option for skull base reconstruction.  \nIntroduction  \nThe endoscopic endonasal approach (EEA) for pituitary neuroendocrine tumors (PitNETs) was first introduced by Jho et al.1 Thereafter, it has been used to manage various lesions in the sella turcica and parasellar region.  \nreceived  \nAugust 11, 2024  \naccepted after revision November 4, 2024  \naccepted manuscript online November 7, 2024  \narticle published online November 29, 2024  \nDOI [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.1055/a-2462-8835.](10.1055/a-2462-8835.)[ ](10.1055/a-2462-8835.)[ISSN](ISSN 2193-6331.)[ 2193-6331.](ISSN 2193-6331.)  \nEEA is a minimally invasive surgical technique for resecting sellar and parasellarlesions. It has several advantages. For example, it has a wide panoramic view and can facilitate enhanced visualization of relevant anatomical structures.2 However, the risk of cerebrospinal fluid (CSF) leakage has increased with the expansion of surgical indications.3  \n© 2024 . The Author(s) .  \nThis is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by-nc-nd/4.0/](licenses/by-nc-nd/4.0/))  \nGeorg Thieme Verlag KG, Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany  \n58 Dural Closure Method Using Dural Suture and Polyglycolic ","cbCaiu9GYsXRgrml","https://ap.wps.com/l/cbCaiu9GYsXRgrml","pdf",4730274,"English","# Introduction\n# Methods\n# Results\n# Conclusion","[{\"question\":\"What surgical problem does the dural closure method aim to address?\",\"answer\":\"It targets prevention of postoperative cerebrospinal fluid (CSF) leakage during endoscopic endonasal approach procedures for sellar and parasellar lesions.\"},{\"question\":\"How does the S-PGA method differ from the earlier fat-filling approach?\",\"answer\":\"S-PGA uses dural sutures with a polyglycolic acid (PGA) nonwoven fabric, while the fat-filling method relies on fat graft-based reconstruction with fibrin glue after fat filling.\"},{\"question\":\"What were the key outcome results regarding postoperative CSF leakage?\",\"answer\":\"Postoperative CSF leakage was 0.8% for the S-PGA method and 5.2% for the fat-filling method, indicating a significant improvement (P \\u003c 0.01).\"}]","Dural Closure Method Using Dural Suture and Polyglycolic Acid Nonwoven Fabric in the Endoscopic Endonasal Approach | PDF",1790702662,15]