[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-425780-105":59,"doc-detail-425780-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","duloxetine-plus-exercise-for-knee-osteoarthritis-targeting-pain-and-depression-using-combined-treatment","DULOXETINE PLUS EXERCISE FOR KNEE OSTEOARTHRITIS - Targeting Pain and Depression Using Combined Treatment","","Pain and depressive symptoms frequently co-occur in knee osteoarthritis, and treating one does not reliably improve the other due to bidirectional effects. This 12-week pilot study evaluated a hybrid aerobic exercise program combined with duloxetine to address both pain and depressive symptoms. From May 2023 to March 2025, symptomatic KOA participants with mild to severe depressive symptoms were recruited, dosed with duloxetine 30 mg titrated to 60 mg, and assessed at baseline and 12 weeks.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/duloxetine-plus-exercise-for-knee-osteoarthritis-targeting-pain-and-depression-using-combined-treatment/425780/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/duloxetine-plus-exercise-for-knee-osteoarthritis-targeting-pain-and-depression-using-combined-treatment/425780.png","ImageObject",300,407,{"name":92,"@type":93},"Damian","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the goal of combining duloxetine with exercise in this pilot study?","Question",{"text":113,"@type":114},"To treat both knee osteoarthritis pain and depressive symptoms using a combined exercise–pharmacologic approach over 12 weeks.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Who participated and how was the intervention delivered?",{"text":118,"@type":114},"Participants with symptomatic KOA and mild to severe depressive symptoms were recruited, receiving a hybrid walking program and duloxetine starting at 30 mg and titrated to 60 mg.",{"name":120,"@type":111,"acceptedAnswer":121},"What outcomes improved after 12 weeks?",{"text":122,"@type":114},"KOOS pain subscale scores increased (less pain) and Hamilton Depression Rating Scale scores decreased (fewer depressive symptoms). Physical function also improved on 6-Minute Walk Distance and Chair Stands.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},425780,1790764556,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":24,"preview_page_count":4},137451208677,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Innovation in Aging, 2025, Vol. 9, No. S2 1169  \nAbstract citation ID: igaf122.3919  \nDULOXETINE PLUS EXERCISE FOR KNEE  \nOSTEOARTHRITIS: TARGETING PAIN AND  \nDEPRESSION USING COMBINED TREATMENT  \nAlan Rathbun1, Yu Dong1, Brock Beamer2, Mark Luborsky3, Michelle Shardell1, Claudia Campbell4, Grace Lo5, and  \nAlice Ryan1, 1. University of Maryland School of Medicine, Baltimore, Maryland, United States, 2. University of Maryland,  \nBaltimore, Maryland, United States, 3. Wayne State University, Detroit, Michigan, United States, 4. Johns Hopkins University School of Medicine, Baltimore, Maryland, United States,  \n5. Baylor College of Medicine, Houston, Texas, United States  \nPain and depressive symptoms represent the most common knee osteoarthritis (KOA) phenotype, and their co-occurrence causes bidirectional effects that complicate treatment. Intervening on one condition does not necessarily improve the other. This pilot study tested a 12-week hybrid aerobic exercise program plus duloxetine to treat pain and depressive symptoms in KOA.  \n1170 Innovation in Aging, 2025, Vol. 9, No. S2  \nBetween May 2023 and March 2025, participants with symptomatic KOA and mild to severe depressive symptoms were recruited from the University of Maryland, the VA Maryland Health Care System, and the Baltimore area. The intervention combined a hybrid walking program (two home-based and one supervised session per week) with duloxetine, initiated at 30 mg and titrated to 60 mg. Outcomes were collected at baseline and  \n12 weeks: Knee injury and Osteoarthritis Outcome Score (KOOS) pain subscale, Hamilton Depression Rating Scale (HAM-D), 6-Minute Walk Distance (6MWD), and Chair Stands. Acceptability was evaluated through recruitment, adherence, and dropout. Recruitment exceeded targets (N = 20), and 34 participants enrolled; 21 initiated treatment and 17 completed the protocol, with >80% adherence. KOOS pain scores increased, indicating less pain (+14.2, 95% CI [6.5, 21.9], d = 0.95), while HAM-D scores decreased, implying fewer depressive symptoms (−5.5, 95% CI [−9.0, −2.0], d = 0.81) .  \nPhysical function also improved (6MWD = +130 ft, 95% CI [56.7, 204.1], d = 0.91; Chair Stands = +1.8 repetitions, 95% CI [0.7, 2.8], d = 0.88) . This study demonstrates acceptability, high adherence, and large efficacy signals for a combined exercise–pharmacologic protocol and underscores the need for rigorous evaluation in clinical trials.","cbCaigFwkXxKPz5m","https://ap.wps.com/l/cbCaigFwkXxKPz5m","pdf",2011494,"English","# Abstract\n## Study design and participants\n## Intervention and outcomes\n## Acceptability and results","[{\"question\":\"What was the goal of combining duloxetine with exercise in this pilot study?\",\"answer\":\"To treat both knee osteoarthritis pain and depressive symptoms using a combined exercise–pharmacologic approach over 12 weeks.\"},{\"question\":\"Who participated and how was the intervention delivered?\",\"answer\":\"Participants with symptomatic KOA and mild to severe depressive symptoms were recruited, receiving a hybrid walking program and duloxetine starting at 30 mg and titrated to 60 mg.\"},{\"question\":\"What outcomes improved after 12 weeks?\",\"answer\":\"KOOS pain subscale scores increased (less pain) and Hamilton Depression Rating Scale scores decreased (fewer depressive symptoms). Physical function also improved on 6-Minute Walk Distance and Chair Stands.\"}]","DULOXETINE PLUS EXERCISE FOR KNEE OSTEOARTHRITIS - Targeting Pain and Depression Using Combined Treatment | PDF",1790638307]