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Clinical samples from five cervical squamous cell carcinoma patients and five chronic cervicitis patients were analyzed, alongside DUSP14 overexpression in HeLa and SiHa cells. Gene and protein changes were assessed by qRT-PCR and western blotting, while viability, apoptosis, and migration were measured using CCK-8, flow cytometry, Transwell, and wound healing 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cells by regulating the transforming growth factor-beta-activated kinase 1 and NOD-like receptor pyrin domain containing 3 inflammatory pathways  \nYuanyuan Zhang , Qian Zhuo,  \nShaliya Abuduwufu and Aerziguli Wushouer  \nJournal of International Medical Research 2026, Vol. 54(4) 1–18! The Author(s) 2026 Article reuse guidelines:  \n[sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/03000605261441200](DOI: 10.1177/03000605261441200)[ ](DOI: 10.1177/03000605261441200)[journals.sagepub.com/home/imr](journals.sagepub.com/home/imr)  \nAbstract  \nObjective: This study investigated the role and mechanism of dual-specificity phosphatase 14 in cervical cancer.  \nMethods: In this experimental study, clinical samples from five patients with cervical squamous cell carcinoma and five with chronic cervicitis were analyzed. Dual-specificity phosphatase 14 was overexpressed in HeLa and SiHa cells. Gene and protein expression levels were analyzed using real-time quantitative polymerase chain reaction and western blot analysis. Cell viability, apoptosis, and migration were assessed using cell counting kit-8, flow cytometry as well as Transwell and wound healing assays. Cytokine levels were measured using enzyme-linked immunosorbent assay. Results: Dual-specificity phosphatase 14 expression was significantly downregulated in cervical cancer tissues and cell lines compared with that in their respective controls (p \u003C0.05). Dualspecificity phosphatase 14 overexpression markedly inhibited cell viability and induced apoptosis in HeLa and SiHa cells (p \u003C0.05). Furthermore, it significantly suppressed cell migration (p \u003C0.05). At the molecular level, dual-specificity phosphatase 14 upregulation decreased  \nThe Fifth Department of Gynecological Surgery, the Affiliated Tumor Hospital of Xinjiang Medical University, P. R. China  \nCorresponding author:  \nYuanyuan Zhang, the Fifth Department of Gynecological Surgery, the Affiliated Tumor Hospital of Xinjiang Medical University, No. 789, Suzhou East Street, Urumqi 830000, P. R. China.  \nEmail: [519602409@qq.com](519602409@qq.com)  \nCreative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative  \nCommons Attribution-NonCommercial 4.0 License ([https://creativecommons.org/licenses/by-nc/4.0/](https://creativecommons.org/licenses/by-nc/4.0/)) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ([https://us.sagepub.com/en-us/nam/open-access-at-sage](https://us.sagepub.com/en-us/nam/open-access-at-sage)).  \nmessenger ribonucleic acid levels of transforming growth factor-beta-activated kinase 1, NOD-like receptor pyrin domain containing 3, interleukin-1 beta, and tumor necrosis factoralpha; reduced protein levels of phosphorylated transforming growth factor-beta-activated kinase 1 and NOD-like receptor pyrin domain containing 3; and diminished secretion of interleukin-1 beta and tumor necrosis factor-alpha cytokines (p \u003C0.05).  \nConclusion: Dual-specificity phosphatase 14 acts as a tumor suppressor in cervical cancer by inhibiting proliferation and migration, promoting apoptosis, and suppressing the transforming growth factor-beta-activated kinase 1/NOD-like receptor pyrin domain containing 3 inflammatory pathway, highlighting its potential as a novel therapeutic target and biomarker.  \nKeywords  \nCervical cancer, dual-specificity phosphatase 14, apoptosis, transforming growth factorbeta-activated kinase 1, NOD-like receptor pyrin domain containing 3  \nDate received: 17 September 2025; accepted: 25 March 2026  \nIntroduction  \nCervical cancer is one of the most common types of cancer responsible for morbidity and mortality in women worldwide. According to data from the World Health Organization, approximate","cbCaiqa08UdJ4EwQ","https://ap.wps.com/l/cbCaiqa08UdJ4EwQ","pdf",1424273,18,"English","# Abstract\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What was the main objective of the study?\",\"answer\":\"To investigate the role and mechanism of dual-specificity phosphatase 14 in cervical cancer.\"},{\"question\":\"How was DUSP14 manipulated in the experiments?\",\"answer\":\"Dual-specificity phosphatase 14 was overexpressed in HeLa and SiHa cervical cancer cells.\"},{\"question\":\"What effects did DUSP14 overexpression have on cervical cancer cells?\",\"answer\":\"It significantly inhibited cell viability, induced apoptosis, and suppressed cell migration in HeLa and SiHa cells.\"}]","Dual-specificity phosphatase 14 inhibits the growth of cervical cancer cells by regulating the transforming growth factor-beta-activated kinase 1 and NOD-like receptor pyrin domain containing 3 inflammatory pathways | PDF",1790127029,45]