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This retrospective study evaluated the effectiveness of a 675 nm laser and microfocused ultrasound (MFU), used individually or in combination, for facial aging. Data from 115 patients were analyzed in three groups (675 nm laser, MFU, combined protocol). Efficacy was assessed using the Fitzpatrick Wrinkle Scale and Baker Gravitational Ptosis Classification with standardized photographs at 1, 3, and 6 months. At 6 months, the combined protocol produced greater improvements in wrinkles and laxity, with no major side effects.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/dual-modality-approach-with-675-nm-laser-and-microfocused-ultrasound-for-facial-aging-retrospective-evaluation/433861/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/dual-modality-approach-with-675-nm-laser-and-microfocused-ultrasound-for-facial-aging-retrospective-evaluation/433861.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What treatment modalities were compared in this study?","Question",{"text":113,"@type":114},"The study compared 675 nm laser alone, microfocused ultrasound (MFU) alone, and a combined protocol using both modalities.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was efficacy measured during follow-up?",{"text":118,"@type":114},"Efficacy was evaluated with the Fitzpatrick Wrinkle Scale (FWS), the Baker Gravitational Ptosis Classification (BGP), and standardized photographic assessments at 1, 3, and 6 months.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the main findings at the 6-month evaluation?",{"text":122,"@type":114},"Patients treated with the combined protocol showed more pronounced improvements in wrinkle reduction and laxity reduction than either single-treatment group, and no major side effects were observed.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},433861,1790865278,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Lasers in Medical Science (2026) 41:7  \n[https://doi.org/10.1007/s10103-025-04728-w](https://doi.org/10.1007/s10103-025-04728-w)  \nRESEARCH  \nDual-modality approach with 675 nm laser and microfocused ultrasound for facial aging: retrospective evaluation  \nElena Zappia1,2 · Corinna Genovesi3 · Domenico Piccolo3 · Federica Trovato4 · Martina Tolone5 · Luca Gargano5 · Alessandro Clementi6 · Giuseppe Lodi7 · Annunziata Dattola5 · Steven Paul Nisticò5  \nReceived: 27 September 2025 / Accepted: 28 October 2025 © The Author(s) 2026  \nAbstract  \nCutaneous aging is characterized by gradual structural and functional alterations, including collagen breakdown and reduced elasticity. In recent years, several energy-based modalities have been introduced to address these changes. The aim of this study was to assess the effectiveness of a 675 nm laser and microfocused ultrasound (MFU), applied individually or in combination, for the treatment of facial aging. This retrospective analysis included 115 patients, allocated into three groups: Group A (675 nm laser), Group B (MFU), and Group C (combined protocol) . Efficacy was evaluated through the Fitzpatrick Wrinkle Scale (FWS), the Baker Gravitational Ptosis Classification (BGP), and standardized photographic assessments at 1, 3, and 6 months following treatment. At the 6-month evaluation, individuals treated with the combined protocol exhibited a more pronounced improvement in wrinkle reduction (FWS: from 1.88 to 1.13) and laxity reduction (BGP: from 2.78 to 1.55) compared with either single-treatment group. No major side effects were observed. The combined application of the 675 nm laser and MFU appears to potentiate collagen remodeling and skin tightening more effectively than monotherapy. Further prospective studies are needed to validate these results and further clarify the molecular pathways involved.  \nKeywords 675 nm laser · High frequency ultrasound · Facial aging · Collagen stimulation  \n􀀍 Elena Zappia [elena.zappia@hotmail.it](elena.zappia@hotmail.it)  \nCorinna Genovesi  \n[corinnagenovesi@gmail.com](corinnagenovesi@gmail.com)  \nDomenico Piccolo [domenico.piccolo.skincenters@gmail.com](domenico.piccolo.skincenters@gmail.com)[ ](domenico.piccolo.skincenters@gmail.com)Federica Trovato  \n[federica.trovato01@libero.it](federica.trovato01@libero.it)  \nMartina Tolone  \n[tolonemartina91@gmail.com](tolonemartina91@gmail.com)  \nLuca Gargano  \n[lucagargano1995@gmail.com](lucagargano1995@gmail.com)  \nAlessandro Clementi  \n[dott.alessandroclementi@gmail.com](dott.alessandroclementi@gmail.com)[ ](dott.alessandroclementi@gmail.com)Giuseppe Lodi  \n[giuseppe.lodi@hotmail.com](giuseppe.lodi@hotmail.com)  \nAnnunziata Dattola  \n[annunziata.dattola@uniroma1.it](annunziata.dattola@uniroma1.it)  \nSteven Paul Nisticò  \n[steven.nistico@uniroma1.it](steven.nistico@uniroma1.it)  \n1 Department of Medical Sciences, University of Turin, Turin, Italy  \n2 Department of Health Sciences, Magna Graecia University, Catanzaro, Italy  \n3 Skin Centers, Private Practice, Avezzano-Pescara, Italy  \n4 Dermatology Unit, Istituto Dermopatico dell’Immacolata, Rome, Italy  \n5 Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy  \n6 Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy  \n7 Dermatologic Unit, University of Campania Luigi Vanvitelli, Caserta, Italy  \n1 3  \nIntroduction  \nHumans have always sought to counteract the effects of aging, particularly its visible signs on the body. In recent decades in Western countries the pursuit of anti-aging treatments has intensified, largely due to the visual-centric nature of social media, where aesthetics play a crucial role. Moreover, in the post-pandemic era, with increased reliance on virtual communication for work and social interactions, individuals have become more conscious of facial aging, given its constant exposure in digital media. The progressive reduction of the regenerative capacity of the tissues is a ","cbCainH8edhQaVb0","https://ap.wps.com/l/cbCainH8edhQaVb0","pdf",1563678,"English","# Abstract\n# Keywords\n# Introduction","[{\"question\":\"What treatment modalities were compared in this study?\",\"answer\":\"The study compared 675 nm laser alone, microfocused ultrasound (MFU) alone, and a combined protocol using both modalities.\"},{\"question\":\"How was efficacy measured during follow-up?\",\"answer\":\"Efficacy was evaluated with the Fitzpatrick Wrinkle Scale (FWS), the Baker Gravitational Ptosis Classification (BGP), and standardized photographic assessments at 1, 3, and 6 months.\"},{\"question\":\"What were the main findings at the 6-month evaluation?\",\"answer\":\"Patients treated with the combined protocol showed more pronounced improvements in wrinkle reduction and laxity reduction than either single-treatment group, and no major side effects were observed.\"}]","Dual-modality approach with 675 nm laser and microfocused ultrasound for facial aging - retrospective evaluation | PDF",1790665752,25]