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The review focuses on repurposing antibiotics for cancer therapy, emphasizing advantages over developing new molecular entities. It describes how antibiotics can protect vulnerable cancer patients from infections by killing bacteria and influencing tumor cell growth. Examples include aspirin, metformin, and chloroquine, and discusses anticancer antibiotic classes such as anthracyclines.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/drug-repurposing-of-selected-antibiotics-an-emerging-approach-in-cancer-drug-discovery/330908/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/drug-repurposing-of-selected-antibiotics-an-emerging-approach-in-cancer-drug-discovery/330908.png","ImageObject",300,407,{"name":92,"@type":93},"Maeve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is drug repurposing and why is it used in cancer drug discovery?","Question",{"text":112,"@type":113},"Drug repurposing tests new therapeutic applications for already approved medications. It is described as faster, safer, easier to arrange, and cost-effective, with relatively low risk compared with creating new molecular entities.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do antibiotics relate to cancer therapy in the review?",{"text":117,"@type":113},"Antibiotics help protect cancer patients from infections due to weakened immune systems. The review also explains that antibiotics can contribute to anticancer effects by influencing bacterial killing and processes tied to cancer cell growth, and notes their repurposing as potent anticancer agents.",{"name":119,"@type":110,"acceptedAnswer":120},"What challenges does drug repurposing face according to the document?",{"text":121,"@type":113},"The review highlights challenges such as many drugs not being cost-effective and issues with bacterial resistance. It also notes that drug resistance in cancer is a major problem, with multiple mechanisms involved.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330908,1790099344,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","This article is licensed under CC-BY-NC-ND 4.0   \n[http://pubs.acs.org/journal/acsodf](http://pubs.acs.org/journal/acsodf)  Review   \nDrug Repurposing of Selected Antibiotics: An Emerging Approach in Cancer Drug Discovery  \nNilofer Bano, Sana Parveen, Mohd Saeed, Samra Siddiqui, Mohammad Abohassan, and Snober S. Mir*  \n Cite This: ACS Omega 2024, 9, 26762−26779  \nRead Online  \n\n|  |  |  |  |\n| --- | --- | --- | --- |\n| ACCESS   | Metrics & More |  |  Article Recommendations |\n\nABSTRACT: Drug repurposing is a method of investigating new therapeutic applications for previously approved medications. This repurposing approach to “old” medications is now highly efficient, simple to arrange, and cost-effective and poses little risk of failure in treating a variety of disorders, including cancer. Drug repurposing for cancer therapy is currently a key topic of study. It is a way of exploring recent therapeutic applications for already-existing drugs. Theoretically, the repurposing strategy has various advantages over the recognized challenges of creating new molecular entities, including being faster, safer, easier, and less expensive. In the real world, several medications have been repurposed, including aspirin, metformin, and chloroquine. However, doctors and scientists address numerous challenges when repurposing drugs, such as the fact that most drugs are not cost-effective and are resistant to bacteria. So the goal of this review is to gather information regarding repurposing pharmaceuticals to make them more cost-effective and harder for bacteria to resist. Cancer patients are more susceptible to bacterial infections. Due to their weak immune systems, antibiotics help protect them from a variety of infectious diseases. Although antibiotics are not immune boosters, they do benefit the defense system by killing bacteria and slowing the growth of cancer cells. Their use also increases the therapeutic efficacy and helps avoid recurrence. Of late, antibiotics have been repurposed as potent anticancer agents because of the evolutionary relationship between the prokaryotic genome and mitochondrial DNA of eukaryotes. Anticancer antibiotics that prevent cancer cells from growing by interfering with their DNA and blocking growth of promoters, which include anthracyclines, daunorubicin, epirubicin, mitoxantrone, doxorubicin, and idarubicin, are another type of FDA-approved antibiotics used to treat cancer. According to the endosymbiotic hypothesis, prokaryotes and eukaryotes are thought to have an evolutionary relationship. Hence, in this study, we are trying to explore antibiotics that are necessary for treating diseases, including cancer, helping people reduce deaths associated with various infections, and substantially extending people’s life expectancy and quality of life.  \n■ INTRODUCTION  \nCancer is a common and often-seen disease that poses a serious health risk to people. Cancer is caused by abnormal cells growing out of control and the genome changing quickly (which causes cancerous features in normal cells). 1 In 2020, there was an estimate of 19 million new cases of cancer and nearly 10 million deaths due to cancer.2 Cancer’s basic cause is the aberrant cell growth and motility caused by an unregulated  \n\n| Received: January 18, 2024\u003Cbr>Revised: May 19, 2024\u003Cbr>Accepted: May 29, 2024\u003Cbr>Published: June 13, 2024 | |\n| --- | --- |\n\n© 2024 The Authors. Published by American Chemical Society  \n26762  \n[https://doi.org/10.1021/acsomega.4c00617](https://doi.org/10.1021/acsomega.4c00617)  \nACS Omega 2024, 9, 26762−26779  \ncell cycle and the constant cancer stem cell self-renewal and reproduction.3 The spread of cancer interferes with typical biological processes, including those of healthy cells. This is completed by infiltrating and spreading to adjacent tissues.4 Usually, cancer therapies include radiation therapy, chemotherapy, surgery, laser therapy, and combination therapy. Selective treatments have been found to improve the know","cbCaikKrTCief5y6","https://ap.wps.com/l/cbCaikKrTCief5y6","pdf",5647128,18,"English","# ABSTRACT\n# INTRODUCTION\n# DRUG RESISTANCE\n## Mechanisms of drug resistance\n# REFERENCES (IMPLIED)","[{\"question\":\"What is drug repurposing and why is it used in cancer drug discovery?\",\"answer\":\"Drug repurposing tests new therapeutic applications for already approved medications. It is described as faster, safer, easier to arrange, and cost-effective, with relatively low risk compared with creating new molecular entities.\"},{\"question\":\"How do antibiotics relate to cancer therapy in the review?\",\"answer\":\"Antibiotics help protect cancer patients from infections due to weakened immune systems. The review also explains that antibiotics can contribute to anticancer effects by influencing bacterial killing and processes tied to cancer cell growth, and notes their repurposing as potent anticancer agents.\"},{\"question\":\"What challenges does drug repurposing face according to the document?\",\"answer\":\"The review highlights challenges such as many drugs not being cost-effective and issues with bacterial resistance. It also notes that drug resistance in cancer is a major problem, with multiple mechanisms involved.\"}]","Drug Repurposing of Selected Antibiotics - An Emerging Approach in Cancer Drug Discovery | PDF",1789990680,45]