[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-400466-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-400466-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","doxycycline-post-exposure-prophylaxis-for-sexually-transmitted-infection-prevention-doxypep","Doxycycline Post-Exposure Prophylaxis for Sexually Transmitted Infection Prevention (DoxyPEP)","","Doxycycline Post-Exposure Prophylaxis (DoxyPEP) is an antibiotic taken after sex to help prevent sexually transmitted infections (STIs). Taking doxycycline reduces STI risk by up to 50% in people born as male. Guidance covers timing after condomless sex, repeat dosing windows, limits on total daily dosage, and daily use during ongoing condomless sex. It also includes administration tips (water, upright posture, possible food), sun sensitivity precautions, and how to manage interactions with dairy, calcium, antacids, and vitamins. Additional sections address effects on intestinal “good” bacteria and antibiotic resistance, and emphasize ongoing STI testing, limits of protection, and consultation for HIV prevention options such as PrEP/PEP.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/doxycycline-post-exposure-prophylaxis-for-sexually-transmitted-infection-prevention-doxypep/400466/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/doxycycline-post-exposure-prophylaxis-for-sexually-transmitted-infection-prevention-doxypep/400466.png","ImageObject",300,407,{"name":42,"@type":43},"Cart","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-27",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"When should DoxyPEP be taken after sex?","Question",{"text":63,"@type":64},"Two 100 mg tablets should be taken within 24 hours, but no later than 72 hours after condomless sex. Condomless sex includes oral, anal, or vaginal/front-hole sex without a condom for the entire time.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Can DoxyPEP be taken again if you have sex again soon after the first dose?",{"text":68,"@type":64},"If you have sex again within 24–72 hours of taking doxycycline, take another dose 24–72 hours after your last dose. Do not take more than 200 mg (two 100 mg pills) within 24 hours, and doxycycline can be taken as often as every day during ongoing condomless sex.",{"name":70,"@type":61,"acceptedAnswer":71},"What does DoxyPEP not protect against, and what should you do next?",{"text":72,"@type":64},"DoxyPEP does not protect against MPOX, HIV, or other viral infections. Continue getting tested for STIs every three months and whenever symptoms are present, and discuss PrEP/PEP options for HIV prevention with a health care provider.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},400466,1790673519,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":22,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":30,"preview_page_count":4},18829141979164,"https://eur-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Doxycycline Post-Exposure Prophylaxis for Sexually Transmitted Infection Prevention (DoxyPEP)  \nDoxycycline Post-Exposure Prophylaxis (DoxyPEP) means taking the antibiotic, doxycycline, after sex to prevent getting a sexually transmitted infection (STI) . Taking DoxyPEP reduces the chance of getting an STI by up to 50% in people born as male.  \nWhen should I take DoxyPEP?  \nTwo 100 milligram tablets of doxycycline should betaken within 24 hours, but no later than 72 hours after sex without a condom. Condomless sex means any oral, anal, or vaginal/front-hole sex where a condom is not used for the entire time.  \nCan I take DoxyPEP again if I have sex again?  \nIf you have sex within 24-72 hours of taking doxycycline, take another dose 24-72 hours after your last dose. It is important not to take more than 200 mg (two 100 mg pills) within 24 hours.  \nDoxycycline can be taken as often as every daywhen you are having sex without a condom.  \nHow should I take DoxyPEP?  \nDoxycycline should be taken with plenty of water or another liquid, so it does not get stuck when swallowed. Remain upright for 30 minutes after taking doxycycline. If your stomach is upset by doxycycline, taking it with food may help.  \nWear sunscreen as some people are more sensitive to the sun after they have taken doxycycline.  \nDo not share doxycycline with others.  \nAvoid dairy products, calcium, antacids, and multivitamins two hours before and after taking doxycycline.  \nDoes DoxyPEP affect normal (“good”)  \nbacteria in our intestines?  \nDoxycycline appears to be less likely than other antibiotics to affect the good bacteria. Researchers are currently studying this.  \nWill DoxyPEP make me resistant to antibiotics if I get an infection? (For example, staph or STI)?  \nIt may or may not increase resistance to other bacteria. Researchers are currently studying this.  \nThere is no known resistance to doxycycline in chlamydia or syphilis at this time.  \nAbout 25% of gonorrhea cases in the United States are already resistant to doxycycline.  \nReminders:  \n• Continue to get tested for STIs every three months and whenever symptoms are present.  \n• DoxyPEP does not protect against:  \no MPOX  \no Human Immunodeficiency Virus (HIV)  \no Other viral infections  \n• Talk to your health care provider about preexposure prophylaxis (PrEP) and postexposure to prophylaxis (PEP) for HIV prevention.  \n• For those living with HIV, continue to take your medications and consult your healthcare provider regularly.  \n• For more information on STI Prevention, select link or scan the QR code:  \n[https://www.hiv.va.gov/patient/sexually](https://www.hiv.va.gov/patient/sexually)transmitted-infections.asp","cbCairHXhQPyJ6zV","https://ap.wps.com/l/cbCairHXhQPyJ6zV","pdf",165151,"English","# DoxyPEP overview\n## When to take DoxyPEP and dosing schedule\n## How to take DoxyPEP safely\n## Intestinal bacteria and antibiotic resistance\n## Reminders for STI testing and limitations","[{\"question\":\"When should DoxyPEP be taken after sex?\",\"answer\":\"Two 100 mg tablets should be taken within 24 hours, but no later than 72 hours after condomless sex. Condomless sex includes oral, anal, or vaginal/front-hole sex without a condom for the entire time.\"},{\"question\":\"Can DoxyPEP be taken again if you have sex again soon after the first dose?\",\"answer\":\"If you have sex again within 24–72 hours of taking doxycycline, take another dose 24–72 hours after your last dose. Do not take more than 200 mg (two 100 mg pills) within 24 hours, and doxycycline can be taken as often as every day during ongoing condomless sex.\"},{\"question\":\"What does DoxyPEP not protect against, and what should you do next?\",\"answer\":\"DoxyPEP does not protect against MPOX, HIV, or other viral infections. Continue getting tested for STIs every three months and whenever symptoms are present, and discuss PrEP/PEP options for HIV prevention with a health care provider.\"}]","Doxycycline Post-Exposure Prophylaxis for Sexually Transmitted Infection Prevention (DoxyPEP) | PDF",1790511655]