[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-435868-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-435868-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","double-calcication-in-plnty-an-unusual-presentation-of-a-rare-tumor-in-young-patients","Double calcification in PLNTY - an unusual presentation of a rare tumor in young patients","","A 17-year-old previously healthy female presented with new-onset seizures. CT and MRI identified a right parietal solid lesion containing two densely calcified areas, prompting surgical resection for diagnostic clarification. Histopathology and immunohistochemistry confirmed polymorphous low-grade neuroepithelial tumor of the young (PLNTY). Postoperatively, the patient improved clinically and remained disease-free, consistent with 2021 WHO features such as oligodendroglioma-like morphology and low Ki-67.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/double-calcication-in-plnty-an-unusual-presentation-of-a-rare-tumor-in-young-patients/435868/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/double-calcication-in-plnty-an-unusual-presentation-of-a-rare-tumor-in-young-patients/435868.png","ImageObject",300,407,{"name":42,"@type":43},"Himbo","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-02","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What symptoms led to the patient’s workup?","Question",{"text":63,"@type":64},"The patient presented with new-onset seizures.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What did CT and MRI show in the brain lesion?",{"text":68,"@type":64},"CT and MRI revealed a solid lesion in the right parietal lobe with two densely calcified areas.",{"name":70,"@type":61,"acceptedAnswer":71},"How was the diagnosis of PLNTY confirmed?",{"text":72,"@type":64},"Histopathological and immunohistochemical analyses confirmed PLNTY, including findings such as a very low Ki-67 index and negative markers reported in the figures and text.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},435868,1790764569,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":26,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":97,"preview_page_count":4},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","Article published online: 2025-07-28  \nNeuroimaging 1  \nDouble calcification in PLNTY: an unusual presentation of a rare tumor in young patients  \nDiego Jordão Lino Dias 1 Camilla Akemi Felizardo Yamada2 Carmen Lucia Penteado Lancellotti3 Lázaro Luíz Faria do Amaral 1  \n1 Hospital Beneficência Portuguesa de São Paulo, Divisão de Neurorradiologia, São Paulo SP, Brazil.  \n2 Hospital Beneficência Portuguesa de São Paulo, Divisão de Oncologia Clínica, São Paulo SP, Brazil.  \nArq. Neuro-Psiquiatr. 2025;83(11):s00451809933 .  \nAddress for correspondence Diego Jordão Lino Dias (email: [diax.rad@hotmail.com](diax.rad@hotmail.com))  \n3 Santa Casa de São Paulo, Faculdade de Ciências Médicas, São Paulo SP, Brazil,  \nA 17-year-old, previously healthy, female patient presented with new-onset seizures. Computed tomography and magnetic resonance imaging scans ( ►Figure 1) revealed a solid lesion in the right parietal lobe with two densely calcified  \nareas, suggestive of neoplastic characteristics, which was surgically resected for diagnostic clarification. The histopathological and immunohistochemical analyses ( ►Figure 2) confirmed the diagnosis of polymorphous low-grade  \nFigure 1 Head computed tomography (CT) scan (A,B) demonstrating a deep, solid, and heterogeneously-calcified parenchymal lesion in the right parietal lobe. Axial susceptibility-weighted imaging (SWI) magnietic resonance imaging (MRI) scan (C,D) showing marked hypointensity due to calcification, with emphasis on a smaller component of this lesion in the cortico-subcortical region of the right superior parietal lobule. Axial fluid-attenuated inversion recovery (FLAIR) MRI scan (E) demonstrating the lesion at two levels, with a predominance of hyperintense signal and hypointense areas in the more densely-calcified regions (blue arrows) . A Head CT scan (F), presented in soft tissue and bone windows on the same coronal plane, better characterizes the dual calcification pattern (yellow arrows) . Sagittal T1-weighted MRI scan (G) showing the lesion ’s extension from the cortico-subcortical region to the deep white matter, surrounded by a slight hyperintense halo (red arrows) . Venous MR angiography (H) revealing mild enhancement of the lesion with paramagnetic contrast (green arrows) .  \nreceived March 4, 2025 accepted May 4, 2025  \nDOI [https://doi.org/](https://doi.org/)[ ](https://doi.org/)10.1055/s-0045-1809933 . ISSN 0004-282X  \nEditor-in-Chief: Ayrton Roberto Massaro.  \nAssociate Editor: Antonio José da Rocha.  \n© 2025 . The Author(s) .  \nThis is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/))  \nThieme Revinter Publicações Ltda. , Rua Rego Freitas, 175, loja 1, República, São Paulo, SP, CEP 01220-010, Brazil  \n2 Neuroimaging  \nFigure 2 (A) Hematoxylin and eosin staining (H&E) showing small, round, oligodendroglioma-like cells with slight nuclear variability.  \n(B) H&E staining revealing dense calcifications within both adjacent tumor and non-tumor components. (C) S100-positive cells,(D)GFAP-positive cells, (E,F) Olig2-positive cells, and (F) CD34-positive cells are an important finding to distinguish from oligodendrogliomas. (G)Preserved ATRX.  \n(H) SYN-negative. (I) IDH-1-negative. (J) Very low Ki-67 index (1–2%) . BRAF V600E gene mutations were not found.  \nneuroepithelial tumor of the young (PLNTY). Postoperatively, the patient improved clinically and remains disease-free.  \nThe 2021 World Health Organization classification for PLNTY describes features such as oligodendroglioma-like cellular morphology, microcalcifications, low Ki-67 index, and absence of necrosis.1 The imaging findings and the tumor’s location in the right, non-dominant hemisphere, support the diagnosis.2,3  \nAuthors’ Contributions  \nConceptualization: DJLD, ","cbCaifYN0TtGyl8V","https://ap.wps.com/l/cbCaifYN0TtGyl8V","pdf",2326224,"English","# Case presentation\n## Imaging findings\n## Histopathological and immunohistochemical confirmation\n# Diagnosis and clinical outcome\n# WHO classification context\n# Author contributions\n# Conflict of interest and data availability","[{\"question\":\"What symptoms led to the patient’s workup?\",\"answer\":\"The patient presented with new-onset seizures.\"},{\"question\":\"What did CT and MRI show in the brain lesion?\",\"answer\":\"CT and MRI revealed a solid lesion in the right parietal lobe with two densely calcified areas.\"},{\"question\":\"How was the diagnosis of PLNTY confirmed?\",\"answer\":\"Histopathological and immunohistochemical analyses confirmed PLNTY, including findings such as a very low Ki-67 index and negative markers reported in the figures and text.\"}]","Double calcification in PLNTY - an unusual presentation of a rare tumor in young patients | PDF",1790675666]