[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-437054-105":59,"doc-detail-437054-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","dotatate-scan-in-meningiomatosis-in-a-patient-with-ophthalmoplegia","DOTATATE Scan in Meningiomatosis in a Patient With Ophthalmoplegia","","Case report describing a 51-year-old woman with progressive bilateral ophthalmoplegia and diplopia due to meningiomatosis involving both cavernous sinuses, highlighted by DOTATATE imaging. Her history included Tolosa–Hunt syndrome treatment and incidental meningiomas monitored on MRI. Examination and imaging showed multiple meningiomas, including peri-optic canal lesions and cavernous sinus involvement, leading to neurosurgical referral for symptomatic management. The DOTATATE scan helped identify lesions previously missed and supported diagnosis despite complex prior ocular findings.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/dotatate-scan-in-meningiomatosis-in-a-patient-with-ophthalmoplegia/437054/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/dotatate-scan-in-meningiomatosis-in-a-patient-with-ophthalmoplegia/437054.png","ImageObject",300,407,{"name":92,"@type":93},"Adam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What condition and symptom complex does the case focus on?","Question",{"text":112,"@type":113},"The case focuses on a patient with progressive bilateral ophthalmoplegia and diplopia caused by meningiomatosis involving both cavernous sinuses, highlighted using DOTATATE imaging.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the patient’s prior history influence the diagnostic process?",{"text":117,"@type":113},"The patient had a complicated ocular history including Tolosa–Hunt syndrome treated with steroids and incidental meningiomas monitored by MRI; this background contributed to diagnostic challenges addressed by DOTATATE imaging.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the DOTATATE PET/CT confirm and why was it clinically important?",{"text":121,"@type":113},"The DOTATATE PET/CT confirmed multiple meningiomas, including peri-optic nerve canals and both cavernous sinuses, and was useful for identifying previously missed lesions and supporting the diagnosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},437054,1790779752,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":39},1374404737137,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Wiley  \nCase Reports in Ophthalmological Medicine Volume 2026, Article ID 9978785, 3 pages [https://doi.org/10.1155/crop/9978785](https://doi.org/10.1155/crop/9978785)  \nCase Report  \nDOTATATE Scan in Meningiomatosis in a Patient With Ophthalmoplegia  \nJoshua Pasol , 1 Carolina G. Benjamin ,2 and W. David Honeycutt 3  \n1Bascom Palmer Eye Institute Department of Ophthalmology, University of Miami Miller School of Medicine, Plantation, Florida, USA  \n2Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA  \n3Department of Neurology, Neurology Associates, Maitland, Florida, USA  \nCorrespondence should be addressed to Joshua Pasol; [jpasol@med.miami.edu](jpasol@med.miami.edu)  \nReceived 15 March 2025; Revised 15 July 2025; Accepted 17 November 2025  \nAcademic Editor: Cristiano Giusti  \nCopyright © 2026 Joshua Pasol et al. Case Reports in Ophthalmological Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \nDOTATATE (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid [DOTA]-octreotate) is a compound that binds somatostatin receptors seen in tumors such as meningiomas. Here, we present a case of a patient with progressive bilateral ophthalmoplegia due to meningiomatosis involving both cavernous sinuses, which was highlighted by DOTATATE imaging. Some studies have shown DOTATATE imaging is superior to contrast-enhanced magnetic resonance imaging (MRI) in identifying extent of intraosseous meningioma growth, which has been associated with worse prognosis. DOTATATE imaging should be considered in cases of unknown diagnosis of mass lesions and lesions that are in areas not easily accessible to biopsy, such as the cavernous sinuses.  \nKeywords: cranial nerve palsies; diplopia; DOTATATE scan; meningiomatosis  \n1. Case Presentation  \nA 51-year-old female presented with diplopia and progressive ophthalmoplegia since Age 47 . She had a past ocular history of left eye amblyopia, accommodative esotropia status–post strabismus surgery performed at Age 8, and hyperopia. At Age 18, she experienced painful diplopia and left facial swelling; she was treated with steroids and diagnosed with Tolosa–Hunt syndrome (THS) . At Age 28, she had a recurrence of pain in the left forehead, left sided ptosis, and diplopia, which was treated with steroids for presumed THS. At that time, she was found to have incidental meningiomas on magnetic resonance imaging (MRI), which were monitored. Two lesions were documented on MRI in 2014, a right orbital roof and a planum lesion. She was followed by her strabismologist who noted progressive vertical gaze palsy, unreactive pupils, and a larger angle exotropia, which led to neuro-ophthalmic referral.  \nThe eye examination showed a BCVA of 20/20 OD and 20/30 OS. Humphrey visual fields 24-2 were normal. The anterior segment exam showed punctate epithelial erosions OU, whereas posterior exam showed nasal drusen of the right optic disc and retinal pigmentary epithelial changes in the macula OU. The external exam showed 2mm left upper lid ptosis. Pupils measured 5mm OD and 5.5mm OS in the light and 5.5mm OD and 6mm OS in the dim room. Both pupils were poorly reactive to light. The ocular motility showed 50% supraduction OD in the direction of the superior rectus and inferior oblique and 25% limitation in adduction consistent with a partial right third nerve palsy. The left eye had 50% limitation in supraduction and adduction, 100% limitation in the direction of the inferior rectus and 25% limitation in abduction consistent with left third and sixth nerve palsies. Retinal nerve fiber layer (RNFL) optical coherence tomography (OCT) measured an average thickness of 82μm OD and 92μm OS, whereas the ganglion  \n2 Case Reports in Ophthalmological Medicine  \nFigure 1: On the left panel is ","cbCaid6FClbvZcF5","https://ap.wps.com/l/cbCaid6FClbvZcF5","pdf",938775,"English","# Case Presentation\n## Clinical history and ophthalmologic findings\n## Imaging review and diagnosis\n# Discussion","[{\"question\":\"What condition and symptom complex does the case focus on?\",\"answer\":\"The case focuses on a patient with progressive bilateral ophthalmoplegia and diplopia caused by meningiomatosis involving both cavernous sinuses, highlighted using DOTATATE imaging.\"},{\"question\":\"How did the patient’s prior history influence the diagnostic process?\",\"answer\":\"The patient had a complicated ocular history including Tolosa–Hunt syndrome treated with steroids and incidental meningiomas monitored by MRI; this background contributed to diagnostic challenges addressed by DOTATATE imaging.\"},{\"question\":\"What did the DOTATATE PET/CT confirm and why was it clinically important?\",\"answer\":\"The DOTATATE PET/CT confirmed multiple meningiomas, including peri-optic nerve canals and both cavernous sinuses, and was useful for identifying previously missed lesions and supporting the diagnosis.\"}]","DOTATATE Scan in Meningiomatosis in a Patient With Ophthalmoplegia | PDF",1790680051]