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\nKarla I. Rodríguez-López 1,2, Mariana Salazar-Castillo 1, Leonardo S. Lino-Silva 1, *, Ángeles Galán-Ramírez 1, Luisa F. Rivera-Moncada 1,2, Emiliano A. López-Jiménez 2 and César Zepeda-Najar 3  \nCitation: Rodríguez-López, K.I.; Salazar-Castillo, M.; Lino-Silva, L.S.; Galán-Ramírez, Á .; Rivera-Moncada, L.F.; López-Jiménez, E.A.; ZepedaNajar, C. Does the Presence of Matted Nodes in Colon Adenocarcinoma Influence 5-Year Overall Survival? Medicina 2024, 60, 1194 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)medicina60081194  \nAcademic Editor: Sorin Tiberiu Alexandrescu  \nReceived: 9 June 2024  \nRevised: 16 July 2024  \nAccepted: 21 July 2024  \nPublished: 24 July 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Surgical Pathology, National Cancer Institute (Mexico), Tlalpan 14080, Mexico City, Mexico; [karlaisarolo07012002@gmail.com](karlaisarolo07012002@gmail.com) (K.I.R.-L.); [mariana.salazar.cas@gmail.com](mariana.salazar.cas@gmail.com) (M.S.-C.); [angelesgalan.rmz@gmail.com](angelesgalan.rmz@gmail.com) (Á .G.-R.); [luisafernandarivera08@gmail.com](luisafernandarivera08@gmail.com) (L.F.R.-M.)  \n2 AFINES Program, Medicine Faculty, National Autonomus Universiti of Mexico (UNAM), Coyoacán 04510, Mexico City, Mexico; [emilianolopezjimenez@gmail.com](emilianolopezjimenez@gmail.com)  \n3 Surgical Oncology, Ángeles Tijuana Hospital, Tijuana 22010, Baja California Norte, Mexico; [cz.surgicaloncology@gmail.com](cz.surgicaloncology@gmail.com)  \n* Correspondence: [saul.lino.sil@gmail.com](saul.lino.sil@gmail.com)  \nAbstract: Background and Objectives: Colon cancer (CC) is prevalent globally, constituting 11.9% of cases in Mexico. Lymph node metastases are established prognostic indicators, with extracapsular lymph node extension (ENE) playing a crucial role in modifying prognosis. While ENE is associated with adverse factors, certain aspects, like matted nodes (lymph node conglomerates), are underexplored. Matted nodes, clusters of lymph nodes infiltrated by cancer cells, are recognized as an independent prognostic factor in other cancers. This study investigates the prognostic implications of matted nodes in CC. Materials and Methods: From a retrospective analysis of 502 CC consecutive cases treated with colectomy (2005–2018), we identified 255 (50.8%) cases with lymph node metastasis (our study group), which were categorized into two groups: (1) lymph node metastasis alone (n = 208), and (2) lymph node metastasis with matted nodes (n = 47) . A comparative survival analysis was performed. Results: Of the 255 patients, 38% had lymph node metastasis. Patients with matted nodes (18.4%) showed an association with higher pN stage and lymphovascular invasion. The 5-year survival rate for patients with matted nodes was 47.7%, compared to 60% without (p = 0.096); however, this association demonstrated only a statistical tendency. Multivariate analysis identified clinical stage and adjuvant chemotherapy use as independent factors contributing to survival. Conclusions: This study underscores matted nodes as potential prognostic indicators in CC, emphasizing their association with higher pN stage and reduced survival. Although the patients with matted nodes showed lower survival, this figure did not search statistical significance, but a tendency was detected, which necessitates precise further research, which is essential for validating these findings and integrating matted nodes into the broader context of colorectal cancer management.  \nKeywords: matted nodes; lymph node metastasis;","cbCailQrdgZSnbxn","https://ap.wps.com/l/cbCailQrdgZSnbxn","pdf",680192,"English","# Abstract\n# Introduction\n# Materials and Methods\n# Results\n# Conclusions","[{\"question\":\"What does this study examine about colon adenocarcinoma?\",\"answer\":\"It investigates whether matted nodes in colon adenocarcinoma influence 5-year overall survival in patients with lymph node metastasis.\"},{\"question\":\"How were patients selected and grouped in the study?\",\"answer\":\"From 502 consecutive colon cancer colectomy cases (2005–2018), 255 patients had lymph node metastasis and were divided into metastasis alone (n=208) and metastasis with matted nodes (n=47).\"},{\"question\":\"What were the main survival findings regarding matted nodes?\",\"answer\":\"Patients with matted nodes showed lower 5-year overall survival (47.7%) than those without (60%), with the association described as only a statistical tendency.\"},{\"question\":\"Which factors were identified as independent contributors to survival?\",\"answer\":\"Multivariate analysis indicated clinical stage and the use of adjuvant chemotherapy as independent factors contributing to survival.\"}]","Does the Presence of Matted Nodes in Colon Adenocarcinoma Influence 5-Year Overall Survival? | PDF",1789992302]