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The authors question terminology and study rationale, distinguishing concurrent chemoradiotherapy from short-course approaches, and propose alternative nomenclature (short-course RT + consolidation CT). They also critique the use of propensity score matching based on changes in standard care before and after 2019, noting selective CCRT application to higher-risk patients.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/does-the-different-study-period-influence-outcome-evaluation/436113/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/does-the-different-study-period-influence-outcome-evaluation/436113.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What issue do the authors raise about the original study’s term “chemoradiation”?","Question",{"text":112,"@type":113},"They note that “chemoradiation” was used in two different clinical situations: standard concurrent chemoradiotherapy versus short-course chemoradiotherapy, and they seek clarification of how these differ.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do the authors interpret the described short-course protocol?",{"text":117,"@type":113},"They argue the regimen is a sequential RT followed by consolidation CT, suggesting it should be termed “short-course RT + consolidation CT (CCT)” rather than abbreviated as SCRT.",{"name":119,"@type":110,"acceptedAnswer":120},"Why do the authors question the rationale for the treatment-period comparison?",{"text":121,"@type":113},"They state that comparing periods based on “change” in favorable treatment selection is difficult to justify, especially because concurrent chemoradiotherapy was applied selectively for poorer-risk features, implying uncontrolled limitations.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436113,1790791274,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81,"preview_page_count":4},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","J Chin MedAssoc  \nLetter to the editor  \nDoes “the different study period” influence outcome evaluation?  \nYiu-Tai Lia, Wen-Hsun Changb,c,*  \naDepartment of Obstetrics and Gynecology, Kuo General Hospital, Tainan, Taiwan, ROC; bDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; cDepartment of Nursing, Taipei Veterans General Hospital, Taipei, Taiwan, ROC  \nDEAR EDITOR,  \nWe read Dr. Chang’s article entitled “Short-term outcomes of short-and long-course chemoradiotherapy before total mesorectal excision for locally advanced rectal tumors: A single-center study in Taiwan utilizing propensity score matching” published in August issue of the Journal of Chinese Medical Association with much interest.1 We congratulated their success to offer us the benefits of using neoadjuvant chemoradiation in treatment of patients with locally advanced rectal cancers (LARC) . Neoadjuvant therapy is familiar to us, because for treating gynecologic cancers, the role of neoadjuvant therapy is important. For example, to decrease the complication rate and possible mortality rate secondary to primary cytoreductive surgery for patients with advanced ovarian cancer, neoadjuvant chemotherapy (NACT) in combination of other potential agents, such as immunotherapy (IO) and antiangiogenic agents (bevacizumab) before cytoreductive surgery (called as interval cytoreductive surgery) is considered an alternative consideration for patients unsuitable to immediate surgery due to physical intolerability or impossibility to total and complete resection of their tumors (R0, no visible residual tumor after surgery) .2,3 However, we confused some of the authors’ description and hope the authors could give responses. First, we are confused with the authors’using “chemoradiation,” which appeared in both situations, and one described standard concurrent chemoradiotherapy (CCRT) and the other was the short-course chemoradiotherapy (SCRT) .1 In our limited knowledge, we believe that two clinical practices fulfilling the description of chemoradiotherapy. One is the combination of chemotherapy (CT) and radiotherapy (RT), which indicates both are essential for treatment of main diseases and each of them plays their role independently, such as administration by their own schedule.4 The other is also a combination of CT and RT, but CT is integrating into the main treatment of RT, and plays a chemo-sensitizer to enhance the RT response, and this is often called as CCRT.4 However, we found SCRT may be a sequential treatment protocol containing an initial  \n*Address correspondence. Ms. Wen-Hsun Chang, Department of Nursing, Taipei Veterans General Hospital, 201, Section 2, Shi-Pai Road, Taipei 112, Taiwan,  \n[ROC. E-mail addresses: whchang@vghtpe.gov.tw](ROC. E-mail addresses: whchang@vghtpe.gov.tw); [Whchang818@gmail.com](Whchang818@gmail.com)  \n(W.-H. Chang).  \nConflicts of interest: The authors declare no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2024) 87: 1029.  \nReceived August 14, 2024; accepted August 15, 2024. doi: 10. 1097/JCMA.0000000000001161  \nCopyright © 2024, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc-nd/4.0/](by-nc-nd/4.0/))  \nshort-course pure RT (25 Gy in five fractions) and following at least four courses of FOLFOX therapy (pure CT), suggesting that RT and CT work independently, which had better be called as short-course RT + consolidation CT (CCT) . Can this treatment be abbreviated as SCRT?  \nSecond, the authors attempted to compare the short-term outcomes of patients with LARC treated either with short-course RT + at least four courses of CCT or with conventional CCRT, by utilizing propensity score matching.1 Based on the “change”or “difference” of favor","cbCaigYf19dBrk9W","https://ap.wps.com/l/cbCaigYf19dBrk9W","pdf",251597,"English","# Letter to the editor\n## Clarification of chemoradiotherapy terminology\n## Critique of treatment comparison rationale and propensity score matching","[{\"question\":\"What issue do the authors raise about the original study’s term “chemoradiation”?\",\"answer\":\"They note that “chemoradiation” was used in two different clinical situations: standard concurrent chemoradiotherapy versus short-course chemoradiotherapy, and they seek clarification of how these differ.\"},{\"question\":\"How do the authors interpret the described short-course protocol?\",\"answer\":\"They argue the regimen is a sequential RT followed by consolidation CT, suggesting it should be termed “short-course RT + consolidation CT (CCT)” rather than abbreviated as SCRT.\"},{\"question\":\"Why do the authors question the rationale for the treatment-period comparison?\",\"answer\":\"They state that comparing periods based on “change” in favorable treatment selection is difficult to justify, especially because concurrent chemoradiotherapy was applied selectively for poorer-risk features, implying uncontrolled limitations.\"}]","Does “the different study period” influence outcome evaluation? | PDF",1790676859]