[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-426186-105":59,"doc-detail-426186-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","does-frailty-modify-the-associations-of-late-life-vascular-risk-factors-with-incident-dementia","DOES FRAILTY MODIFY THE ASSOCIATIONS OF LATE-LIFE VASCULAR RISK FACTORS WITH INCIDENT DEMENTIA?","","Late-life vascular risk factors, especially hypertension, remain controversial in relation to dementia. Because frailty is linked to lower blood pressure, the study hypothesized that hypertension—not diabetes or smoking—would relate more strongly to dementia in robust than in pre-frail/frail older adults. Cox proportional hazards models estimated 11-year incident dementia risk using interaction terms between vascular risks and physical frailty in Atherosclerosis Risk in Communities Neurocognitive Study participants.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/does-frailty-modify-the-associations-of-late-life-vascular-risk-factors-with-incident-dementia/426186/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/does-frailty-modify-the-associations-of-late-life-vascular-risk-factors-with-incident-dementia/426186.png","ImageObject",300,407,{"name":92,"@type":93},"Pentious","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-12","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main research hypothesis of this study?","Question",{"text":112,"@type":113},"The study hypothesized that hypertension would be more strongly associated with dementia risk in robust older adults than in pre-frail/frail adults, unlike diabetes or smoking.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the researchers estimate dementia risk over time?",{"text":117,"@type":113},"They used Cox proportional hazards models adjusted for demographic and clinical or lifestyle characteristics, including a multiplicative interaction between vascular risk factors and physical frailty.",{"name":119,"@type":110,"acceptedAnswer":120},"What key result was found regarding blood pressure and frailty?",{"text":121,"@type":113},"There was an interaction between blood pressure and frailty on dementia risk (P=.04), with different hazard ratio patterns for robust versus pre-frail/frail groups.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},426186,1790740294,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},1374404730887,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Innovation in Aging, 2025, Vol. 9, No. S2 1169  \nAbstract citation ID: igaf122.3918  \nDOES FRAILTY MODIFY THE ASSOCIATIONS OF  \nLATE-LIFE VASCULAR RISK FACTORS WITH  \nINCIDENT DEMENTIA?  \nJason Smith1, A. Richey Sharrett2, Priya Palta1,  \nB. Gwen Windham3, Pamela Lutsey4, Alden Gross5, and Jennifer Deal5, 1. UNC School of Medicine, Chapel Hill, North Carolina, United States, 2. Johns Hopkins University, Baltimore, Maryland, United States, 3. University of Mississippi Medical Center-The MIND Center, Jackson, Mississippi, United States, 4. University of Minnesota, Minneapolis, Minnesota, United States, 5. Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States  \nThe contribution of late-life vascular risk factors—hypertension in particular—to dementia remains controversial. Given the association of frailty with lower blood pressure (BP) specifically, we hypothesized that hypertension, but not diabetes or smoking, is more strongly associated with dementia risk in robust than in pre-frail/frail older adults. We used Cox proportional hazards models, adjusted for demographic and clinical/lifestyle characteristics, with a multiplicative interaction term between vascular risk factors and physical frailty (robust versus pre-frail/frail) to estimate cause-specific hazard ratios (HRs) of 11-year incident dementia associated with elevated BP, hypertension, diabetes and current smoking in community-living White and Black participants aged 67-89 years without dementia in the Atherosclerosis Risk in Communities Neurocognitive Study. We then stratified HRs of dementia by frailty. Overall, there were 377 (15.8%) dementia cases in robust participants (n = 2383; mean age, 74.2 years; 55.4% female) and 812 (30.0%) in pre-frail/frail participants (n = 2710; mean age 76.4 years; 61.3% female). There was an interaction between BP and frailty on dementia risk (P=.04) . For robust participants, HRs were 1.06 (95% CI: 0.63-1.77) for elevated BP and 1.34 (95% CI: 0.92-1.94) for hypertension relative to normal BP. For pre-frail/frail participants, HRs were 0.59 (95% CI: 0.40-0. 86) for elevated BP and 0.83 (95% CI: 0.67-1.04) for hypertension relative to normal BP. Diabetes and smoking were associated with increased dementia risk in both robust and pre-frail/frail individuals. Our findings suggest frailty status could be useful for clinical management of BP in older adults to support brain health.","cbCaie3WRZ0zlTYi","https://ap.wps.com/l/cbCaie3WRZ0zlTYi","pdf",1029850,"English","# Methods\n## Statistical approach (Cox proportional hazards)\n# Study population and outcomes\n## Incident dementia over 11 years\n# Results\n## Interaction between blood pressure and frailty\n## Associations by frailty group\n# Implications\n## Clinical management of blood pressure in older adults","[{\"question\":\"What was the main research hypothesis of this study?\",\"answer\":\"The study hypothesized that hypertension would be more strongly associated with dementia risk in robust older adults than in pre-frail/frail adults, unlike diabetes or smoking.\"},{\"question\":\"How did the researchers estimate dementia risk over time?\",\"answer\":\"They used Cox proportional hazards models adjusted for demographic and clinical or lifestyle characteristics, including a multiplicative interaction between vascular risk factors and physical frailty.\"},{\"question\":\"What key result was found regarding blood pressure and frailty?\",\"answer\":\"There was an interaction between blood pressure and frailty on dementia risk (P=.04), with different hazard ratio patterns for robust versus pre-frail/frail groups.\"}]","DOES FRAILTY MODIFY THE ASSOCIATIONS OF LATE-LIFE VASCULAR RISK FACTORS WITH INCIDENT DEMENTIA? | PDF",1790639664]