[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-405923-105":59,"doc-detail-405923-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","does-age-affect-outcome-with-breast-cancer-read-online-free","Does age affect outcome with breast cancer? - read online free","","Prior evidence on how age at breast cancer diagnosis influences patient outcomes and survival remains conflicting. This retrospective, population-based study used the BC Cancer Outcomes Unit database and included 24,469 patients with invasive breast cancer diagnosed from 2005 to 2014, with a median 11.5-year follow-up. Age cohorts (\u003C35 to ≥80) were compared for clinical-pathological features, treatment patterns, breast cancer specific survival (BCSS), and overall survival (OS) by subtype. Marked differences occurred at both extremes, and both young (\u003C40) and elderly (≥80) ages independently predicted worse prognosis after adjusting for subtype, LVI, stage, and treatments. The findings support improved outcome estimation and evidence-based recommendations.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/does-age-affect-outcome-with-breast-cancer-read-online-free/405923/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/does-age-affect-outcome-with-breast-cancer-read-online-free/405923.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn Holloway","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What data and patient cohort were used in the study?","Question",{"text":112,"@type":113},"The study used the Breast Cancer Outcomes Unit database at BC Cancer and analyzed 24,469 patients diagnosed with invasive breast cancer between 2005 and 2014, with a median follow-up of 11.5 years.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did very young patients (\u003C35 to 35–39) differ clinically and in treatment patterns?",{"text":117,"@type":113},"Patients under 35 and those aged 35–39 were more likely to present with higher-risk features, HER2-positive or triple-negative biomarkers, and more advanced TNM stage, and they were more likely to receive mastectomy, axillary lymph node dissection, radiotherapy, and chemotherapy.",{"name":119,"@type":110,"acceptedAnswer":120},"Did age remain a risk factor after adjustment, and what was the clinical implication?",{"text":121,"@type":113},"Yes. Both younger and elderly age at diagnosis were independent risk factors for poorer prognosis after controlling for subtype, LVI, stage, and treatment factors, supporting more accurate outcome estimation and evidence-based treatment recommendations.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},405923,1790764585,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},2336474466712,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","The Breast 70 (2023) 25–31  \nContents lists available at ScienceDirect  \nThe Breast  \njournal [homepage:](homepage: www.journals.elsevier.com/the-breast)[ www.journals.elsevier.com/the-breast](homepage: www.journals.elsevier.com/the-breast)  \n| Does age affect outcome with breast cancer? |  |  | |\n| --- | --- | --- | --- |\n| Emily B Jackson a, c, *, Lovedeep Gondarab, Caroline Speersb, Rekha Dioceeb, Alan M Nichola, c, Caroline Lohrischa, c, Karen A Gelmona, c\u003Cbr>a BC Cancer Vancouver Centre, Vancouver, BC, Canada\u003Cbr>b Breast Cancer Outcomes Unit, BC Cancer, Vancouver, BC, Canada c University of British Columbia, Canada |  |  |  |\n| A R T I C L E I N F O |  | A B S T R A C T |  |\n| Keywords: Breast cancer Age Outcomes\u003Cbr>Adjuvant endocrine therapy Chemotherapy |  | Prior data about the influence of age at diagnosis of breast cancer on patient outcomes and survival has been conflicting. Using the Breast Cancer Outcomes Unit database at BC Cancer, this retrospective population-based study identified a cohort of 24,469 patients diagnosed with invasive breast cancer between 2005 and 2014. Median follow-up was 11.5 years. We analyzed clinical and pathological features at diagnosis and treatment specific variables compared across the following age cohorts: \u003C35, 35–39, 40–49, 50–59, 60–69, 70–79, and 80 years of age and older. We assessed the impact of age on breast cancer specific survival (BCSS) and overall survival (OS) by age and subtype. There were distinct clinical-pathological and treatment pattern differences at both extremes of age at diagnosis. Patients \u003C35 and 35–39 years old were more likely to present with higher risk features, HER2 positive or triple-negative biomarkers, and more advanced TNM stage at diagnosis. They were more likely to undergo treatment with mastectomy, axillary lymph node dissection, radiotherapy and chemotherapy. Conversely, patients ≥80 years old were generally more likely to have hormone-sensitive HER2-negative disease, and lower TNM stage at diagnosis. They were less likely to undergo surgery or be treated with radiotherapy and chemotherapy. Both younger and elderly age at breast cancer diagnosis were independent risk factors for poorer prognosis after controlling for subtype, LVI, stage, and treatment factors. This work will help clinicians to more accurately estimate patient outcomes, patterns of relapse, and provide evidence-based treatment recommendations. |  |\n\n1. Introduction  \nIncreasing age is an important risk factor in breast cancer development. It has also been proposed that patient age at diagnosis impacts breast cancer survival. Elderly age at diagnosis has been associated with a unique clinical-pathological pattern of features, differences in treatment patterns (namely de-escalation approaches), and inferior outcomes [1–3]. Conversely, studies have reported that young age at diagnosis of breast cancer is associated with a unique set of clinical-pathological features and may independently negatively impact survival despite the subtype and intensive treatment conventionally administered [4–9]. While the majority of previous studies indicate that both older and younger age at diagnosis of breast cancer confer worse prognosis, there are numerous studies which do not support this conclusion [10–13]. Thus, previous data has been conflicting. The impact of age at diagnosis on patient outcome and survival is not entirely clear.  \nMany recent studies have suggested that young women have worse outcomes regardless of stage at initial presentation [14,15]. Some partially attribute these disparate outcomes to unfavorable pathological features or biomarker status [16,17]. Whereas other studies suggest only worse outcomes amongst young women when restricted to earlier stage or node negative cancers [18–20].  \nNotably, earlier published studies have examined the impact of age for patients diagnosed up to 2008. This study explores the influence of age at diagnosis on breast cancer outcome in a more c","cbCaiamdCb6Rq6yo","https://ap.wps.com/l/cbCaiamdCb6Rq6yo","pdf",1590044,"English","# Introduction\n## Study context and rationale\n# Study design and methods\n## Patient cohort and follow-up\n## Age cohort comparisons\n# Results\n## Clinical-pathological differences by age\n## Treatment pattern differences by age\n## Survival impact by age and subtype\n# Discussion and implications","[{\"question\":\"What data and patient cohort were used in the study?\",\"answer\":\"The study used the Breast Cancer Outcomes Unit database at BC Cancer and analyzed 24,469 patients diagnosed with invasive breast cancer between 2005 and 2014, with a median follow-up of 11.5 years.\"},{\"question\":\"How did very young patients (\\u003c35 to 35–39) differ clinically and in treatment patterns?\",\"answer\":\"Patients under 35 and those aged 35–39 were more likely to present with higher-risk features, HER2-positive or triple-negative biomarkers, and more advanced TNM stage, and they were more likely to receive mastectomy, axillary lymph node dissection, radiotherapy, and chemotherapy.\"},{\"question\":\"Did age remain a risk factor after adjustment, and what was the clinical implication?\",\"answer\":\"Yes. Both younger and elderly age at diagnosis were independent risk factors for poorer prognosis after controlling for subtype, LVI, stage, and treatment factors, supporting more accurate outcome estimation and evidence-based treatment recommendations.\"}]","Does age affect outcome with breast cancer? - read online free | PDF",1790562562,18]