[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-327707-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-327707-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","dna-methylation-derived-immune-cell-proportions-and-cancer-risk-including-lung-cancer-in-black-participants","DNA Methylation-Derived Immune Cell Proportions and Cancer Risk, Including Lung Cancer, in Black Participants","","Prior cohort studies linking immune cell subtype profiles to cancer risk have largely centered on White populations, limiting understanding of race-specific variation. Using leukocyte DNA methylation deconvolution, immune cell subtype proportions were estimated from baseline blood samples in Black participants of the ARIC study who were cancer-free at enrollment. Over a mean 17.5 years, 668 incident cancers occurred among 2,467 participants. Cox models assessed overall and site-specific risks. Higher T regulatory cell proportions related to increased lung cancer risk, while higher memory B cells related to prostate cancer and all-cancer risk. CD8+ naïve cell proportions showed lower all-cancer risk among those ≥55 years, with most other subtypes not statistically significant. Results broadly align with findings in mostly White groups and support risk stratification for screening and prevention.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/dna-methylation-derived-immune-cell-proportions-and-cancer-risk-including-lung-cancer-in-black-participants/327707/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/dna-methylation-derived-immune-cell-proportions-and-cancer-risk-including-lung-cancer-in-black-participants/327707.png","ImageObject",300,407,{"name":42,"@type":43},"Eliana","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-26","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How were immune cell subtype proportions estimated in this study?","Question",{"text":63,"@type":64},"Immune cell subtype proportions were estimated using deconvolution based on leukocyte DNA methylation markers from blood samples collected at baseline in participants without cancer.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which immune cell subtype was linked to higher lung cancer risk?",{"text":68,"@type":64},"Higher T regulatory cell proportions were associated with a statistically significantly higher lung cancer risk.",{"name":70,"@type":61,"acceptedAnswer":71},"Which immune cell subtype was associated with lower cancer risk in participants aged 55 and above?",{"text":72,"@type":64},"In participants aged ≥55 years, higher CD8+ naïve cell proportions were associated with significantly lower risk of all cancers.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},327707,1790544664,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","medRxiv preprint doi: [https://doi.org/10.1101/2024.05.09.24307118](https://doi.org/10.1101/2024.05.09.24307118); this version posted May 9, 2024. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.  \nIt is made available under a CC-BY-ND 4.0 International license .  \n5/9/2024  \nDNA Methylation-Derived Immune Cell Proportions and Cancer Risk, Including Lung Cancer, in Black Participants  \nAuthors: Christopher S. Semancik1, Naisi Zhao1, Devin C. Koestler2,3, Eric Boerwinkle4,5, Jan Bressler4, Rachel J. Buchsbaum6, Karl T. Kelsey7,8, Elizabeth A. Platz9,10, Dominique S. Michaud1  \nAuthor Affiliations:  \n1 Department of Public Health & Community Medicine, Tufts University School of Medicine, Tufts University, Boston, MA, USA  \n2The University of Kansas Cancer Center, Kansas City, KS, USA  \n3 Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA 4 Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA  \n5 Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA 6 Division of Hematology/Oncology, Tufts Medical Center, Boston, MA, USA 7 Department of Epidemiology, Brown University, Providence, RI, USA  \n8 Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 9 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 10The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA  \nRunning Title: Immune Cell Profiles and Cancer Risk in Black Participants  \nCorresponding Author: Dominique S. Michaud, ScD  \nTufts University School of Medicine  \n136 Harrison Avenue Boston, MA 02111  \nTel: 617-636-0482  \nEmail: [Dominique.Michaud@tufts.edu](Dominique.Michaud@tufts.edu)  \nConflicts of Interest: Dr. Karl Kelsey is a founder and scientific advisor to Cellintec, which had no role in this research. Otherwise, the authors have no conflicts of interest to report.  \nManuscript Notes:  \nWord Count: 3,745 words  \nTotal Number of Tables/Figures: 6 tables (Main Text); 9 tables, 4 figures (Supplementary Materials) Keywords: DNA methylation, immune cell profiles, cancer risk, immunology, epidemiology  \nSection: Epidemiology and Prevention  \nList of Abbreviations (alphabetical order): 95% CI: 95% confidence interval  \nARIC: Atherosclerosis Risk in Communities (cohort study) CD8+ cells: cytotoxic T lymphocytes  \nCpG: CpG oligodeoxynucleotide sites  \nNOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. 1  \nmedRxiv preprint doi: [https://doi.org/10.1101/2024.05.09.24307118](https://doi.org/10.1101/2024.05.09.24307118); this version posted May 9, 2024. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.  \nIt is made available under a CC-BY-ND 4.0 International license .  \nDMR: differentially methylated region  \nDNA: deoxyribonucleic acid  \nHR: hazard ratio  \nMD: Maryland  \nmdNLR: methylation-derived neutrophil-to-lymphocyte ratio  \nMN: Minnesota  \nMS: Mississippi  \nNC: North Carolina  \nSD: standard deviation  \nTME: tumor microenvironment  \nTregs: T regulatory cells  \nWHI: Women’s Health Initiative (cohort study)  \nmedRxiv preprint doi: [https://doi.org/10.1101/2024.05.09.24307118](https://doi.org/10.1101/2024.05.09.24307118); this version posted May 9, 2024. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.  \nIt is made available under a CC-BY-ND 4.0 International license .  \nAbstract  \nPrior cohort studies assessing cancer risk based on immune cell subtype profiles have predominantly focuse","cbCaiqneLlWLVmce","https://ap.wps.com/l/cbCaiqneLlWLVmce","pdf",232688,26,"English","# Abstract\n## Methods and cohort\n## Key findings\n## Implications","[{\"question\":\"How were immune cell subtype proportions estimated in this study?\",\"answer\":\"Immune cell subtype proportions were estimated using deconvolution based on leukocyte DNA methylation markers from blood samples collected at baseline in participants without cancer.\"},{\"question\":\"Which immune cell subtype was linked to higher lung cancer risk?\",\"answer\":\"Higher T regulatory cell proportions were associated with a statistically significantly higher lung cancer risk.\"},{\"question\":\"Which immune cell subtype was associated with lower cancer risk in participants aged 55 and above?\",\"answer\":\"In participants aged ≥55 years, higher CD8+ naïve cell proportions were associated with significantly lower risk of all cancers.\"}]","DNA Methylation-Derived Immune Cell Proportions and Cancer Risk, Including Lung Cancer, in Black Participants | PDF",1789977862,66]