[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-460830-105":3,"detail-sidebar-cat-0-en-105":80,"doc-detail-460830-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","diverse-and-atypical-presentations-of-acroangiodermatitis-of-mali-diagnostic-insights-from-three-cases","Diverse and Atypical Presentations of Acroangiodermatitis of Mali - Diagnostic Insights From Three Cases","","Acroangiodermatitis is an uncommon, benign vasoproliferative entity that often develops in the setting of long-standing venous hypertension or arteriovenous abnormalities. Its clinical resemblance to other dermatoses often results in misdiagnosis and delayed treatment. Three cases, including two males and one female, presented with persistent lower-limb lesions. Clinical, dermoscopic, histopathological, and radiological findings supported acroangiodermatitis of Mali, and venous Doppler confirmed venous insufficiency.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/diverse-and-atypical-presentations-of-acroangiodermatitis-of-mali-diagnostic-insights-from-three-cases/460830/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/diverse-and-atypical-presentations-of-acroangiodermatitis-of-mali-diagnostic-insights-from-three-cases/460830.png","ImageObject",300,407,{"name":42,"@type":43},"Jake","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-07","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":26},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What is the key clinical challenge in diagnosing acroangiodermatitis of Mali?","Question",{"text":62,"@type":63},"Its lesions can closely resemble other dermatoses, which may lead to misdiagnosis and delayed treatment.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"Which evaluations support the final diagnosis in the three reported cases?",{"text":67,"@type":63},"Clinical findings, dermoscopy, histopathology, and radiological assessment, with venous Doppler ultrasound confirming underlying venous insufficiency.",{"name":69,"@type":60,"acceptedAnswer":70},"What treatment approach was initiated after diagnosis?",{"text":71,"@type":63},"Patients were started on oral calcium dobesilate and topical corticosteroids, with referral for vascular surgical evaluation.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},460830,1790759752,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":26,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":79,"read_time":112,"preview_page_count":4},962084928904,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review began 11/12/2025  \nReview ended 12/04/2025  \nPublished 12/09/2025  \n© Copyright 2025  \nPeddireddy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CCBY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98861  \nOpen Access Case Report  \nDiverse and Atypical Presentations of Acroangiodermatitis of Mali: Diagnostic Insights From Three Cases  \nGreeshma Peddireddy 1 , Divya Raviprakash 1, Leena Dennis Joseph 2 , Sudha Rangarajan 1, Adikrishnan Swaminathan 1  \n1. Department of Dermatology, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND 2. Department of General Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND  \nCorresponding author: Divya Raviprakash, [divyaraviprakash123@gmail.com](divyaraviprakash123@gmail.com)  \nAbstract  \nAcroangiodermatitis is an uncommon, benign vasoproliferative entity that often develops in the setting of long-standing venous hypertension or arteriovenous abnormalities. Its clinical resemblance to other dermatoses often results in misdiagnosis and delayed treatment. We describe three cases, two males and one female, who presented with persistent lower limb lesions. Clinical findings included hyperpigmented plaques, indurated plaques, and erythematous soft nodules localized to the legs. Clinically, varicosities were evident in two of the three cases, and one patient had previously undergone surgical vein stripping for the same. Given the chronicity of lesions, biopsies were performed. Histopathological features were consistent with acroangiodermatitis, while dermoscopy showed vascular patterns along with white, structureless areas. Venous Doppler ultrasound confirmed the underlying venous insufficiency in all three cases. Based on clinical, dermoscopic, histopathological, and radiological evaluation, a final diagnosis of acroangiodermatitis of Mali was made. The patients were started on oral calcium dobesilate and topical corticosteroids and were referred for vascular surgical evaluation. This case series highlights the importance of recognizing the diverse and atypical presentations of acroangiodermatitis of Mali, emphasizing that biopsy and dermoscopy are critical for a definitive diagnosis.  \nCategories: Pathology, Dermatology  \nKeywords: acroangiodermatitis of mali, benign, chronic venous insufficiency, pseudo-kaposi sarcoma, vasoproliferative  \nIntroduction  \nAcroangiodermatitis (pseudo-Kaposi sarcoma) is an uncommon, benign, vasoproliferative disorder first recognized by Mali [et al. in 1965](et al. in 1965) [1,2]. This condition represents a reactive angiodysplasia of the cutaneous vasculature and is most frequently associated with chronic venous insufficiency, as well as congenital or acquired arteriovenous malformations. Clinically, it appears as red-violaceous or brown macules, papules, nodules, and plaques primarily located on the extensor surfaces of lower limbs [3] . Four variants of acroangiodermatitis have been documented in the literature. The most common variant is the Mali type, which is associated with chronic venous insufficiency and typically presents bilaterally. The second variant, known as Stewart-Bluefarb syndrome, is linked to congenital arteriovenous malformations and presents unilaterally. The third variant occurs in patients with chronic renal failure and those with iatrogenicarteriovenous shunts. The fourth variant is associated with the first pregnancy [1] . Due to its diverse morphology, acroangiodermatitis can resemble benign conditions, such as stasis dermatitis and lichen planus, as well as aggressive malignant conditions, such as Kaposi sarcoma, which can result in diagnostic uncertainty. Therefore, histopathological examination is essential for definitive diagnosis. This case series highlights the diverse and atypical clinical presenta","cbCaivLQTODHxUEl","https://ap.wps.com/l/cbCaivLQTODHxUEl","pdf",18400456,12,"English","# Abstract\n# Introduction\n# Case Presentation\n## Case 1","[{\"question\":\"What is the key clinical challenge in diagnosing acroangiodermatitis of Mali?\",\"answer\":\"Its lesions can closely resemble other dermatoses, which may lead to misdiagnosis and delayed treatment.\"},{\"question\":\"Which evaluations support the final diagnosis in the three reported cases?\",\"answer\":\"Clinical findings, dermoscopy, histopathology, and radiological assessment, with venous Doppler ultrasound confirming underlying venous insufficiency.\"},{\"question\":\"What treatment approach was initiated after diagnosis?\",\"answer\":\"Patients were started on oral calcium dobesilate and topical corticosteroids, with referral for vascular surgical evaluation.\"}]","Diverse and Atypical Presentations of Acroangiodermatitis of Mali - Diagnostic Insights From Three Cases | PDF"]