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post-surgery utDNA patterns suggested minimal residual disease (6%) and field effect (15%).",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/distinct-longitudinal-patterns-of-urine-tumor-dna-in-patients-undergoing-surveillance-for-bladder-cancer/331507/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/distinct-longitudinal-patterns-of-urine-tumor-dna-in-patients-undergoing-surveillance-for-bladder-cancer/331507.png","ImageObject",300,407,{"name":92,"@type":93},"Eden","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main goal of analyzing urine tumor DNA (utDNA) in this study?","Question",{"text":112,"@type":113},"To evaluate whether utDNA analysis of urine samples can replace cystoscopy for surveillance of bladder cancer recurrence.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How accurate was utDNA detection for identifying recurrences?",{"text":117,"@type":113},"utDNA was detected in 21/23 recurrences, corresponding to 91% sensitivity, including complete detection of T1, T2, and CIS and 83% detection of Ta tumors, with \u003C1% false-negative results.",{"name":119,"@type":110,"acceptedAnswer":120},"How could utDNA analysis change surveillance practices for patients?",{"text":121,"@type":113},"It showed potential to reduce the number of cystoscopies by 55%, benefiting 79% of patients, and it detected many recurrences earlier than cystoscopy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331507,1790125435,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},1374391974468,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Distinct longitudinal patterns of urine tumor DNA inpatients undergoing surveillance for bladder cancer Hege Marie Vedeld 1, Heidi Pharo 1 , Anne Klara Sørbø2, Sara Brandt-Winge 1, May-Britt Five 1, Marine Jeanmougin 1, Per Guldberg3,4 , Rolf Wahlqvist2 and Guro Elisabeth Lind 1,5   \n1 Department of Molecular Oncology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Norway  \n2 Department of Urology, Oslo University Hospital, Norway  \n3 Danish Cancer Society Research Center, Copenhagen, Denmark  \n4 Department of Cancer and Inflammation Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark  \n5 Department of Biosciences, The Faculty of Mathematics and Natural Sciences, University of Oslo, Norway  \nKeywords  \nbiomarker; BladMetrix; DNA methylation;field effect; minimal residual disease; recurrence  \nCorrespondence  \nG. E. Lind, Department of Molecular Oncology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0379 Oslo, Norway  \nTel: +47 22781729  \nE-mail: [guro.elisabeth.lind@rr-research.no](guro.elisabeth.lind@rr-research.no)  \nHege Marie Vedeld and Heidi Pharo are shared first authors.  \n(Received 6 September 2023, revised 20 February 2024, accepted 14 March 2024, available online 8 May 2024)  \ndoi:10 . 1002/1878-0261 .13639  \nCystoscopy is the gold standard for surveillance of non-muscle invasive bladder cancer (NMIBC), but the procedure is invasive and has suboptimal accuracy. The aim of this study was to investigate the potential of analyzing urine samples for the presence of urine tumor DNA (utDNA) to replace cystoscopy for surveillance of bladder cancer recurrence. In this longitudinal, prospective, and observational study, 47 patients were followed for recurrence for 2 years, involving analysis of utDNA using the BladMetrix DNA methylation biomarker test at each cystoscopy. In total, utDNA was detected in 21/23 recurrences (91% sensitivity), including 5/5 T1, T2, and carcinoma in situ (CIS) tumors (100%) and 10/12 Ta tumors (83%), with \u003C 1% false-negative test results. Importantly, utDNA analysis showed the potential to reduce the number of cystoscopies by 55%, benefitting 79% of the patients. Eleven of 23 recurrences (48%) were detected earlier with utDNA than with cystoscopy, and distinct patterns of residual utDNA post-surgery indicated minimal residual disease (MRD) or field effect in 6% and 15% of the patients, respectively. In conclusion, utDNA analysis shows high sensitivity to detect tumor recurrence, potential to reduce the number of cystoscopies, and promise to guide patientspecific surveillance regimens.  \n1. Introduction  \nWith ~ 570 000 new cases each year, bladder cancer is the 10th most commonly diagnosed cancer worldwide, and a leading cause of cancer-related mortality, causing more than 200 000 deaths in 2020 [1] . Approximately 75% of the patients present with non-muscle invasive bladder cancer (NMIBC), generally carrying a  \ngood prognosis, with a 5-year cancer-specific survival close to 90%[2] . Despite a favorable prognosis, thereis a risk of recurrence and progression to muscleinvasive bladder cancer (MIBC), where survival drops to 35% [3] . In high-risk patients, the probability of recurrence and progression at 5 years can reach 78%  \nAbbreviations  \nCIS, carcinoma in situ; ddPCR, droplet digital PCR; dMIQE, Minimum Information for Publication of Quantitative Digital PCR Experiments; EAU, European Association of Urology; EMA, European Medicines Agency; FDA, Food and Drug Administration; MIBC, muscle invasive bladder cancer; MRD, minimal residual disease; NBI, narrow-band imaging; NMIBC, non-muscle invasive bladder cancer; PDD, photodynamic diagnosis; STARD, STAndards for the Reporting of Diagnostic accuracy studies; TURB, transurethral resection of the bladder; utDNA, urine tumor DNA.  \n2684 Molecular Oncology 18 (2024) 2684–2695 ª 2024 The Authors. Molecular Oncology published b","cbCaivCi1Wk2TMZI","https://ap.wps.com/l/cbCaivCi1Wk2TMZI","pdf",1220460,12,"English","# Introduction\n## Bladder cancer burden and recurrence risk\n## Limitations of cystoscopy in surveillance\n## Urine-based biomarkers and current clinical gaps","[{\"question\":\"What is the main goal of analyzing urine tumor DNA (utDNA) in this study?\",\"answer\":\"To evaluate whether utDNA analysis of urine samples can replace cystoscopy for surveillance of bladder cancer recurrence.\"},{\"question\":\"How accurate was utDNA detection for identifying recurrences?\",\"answer\":\"utDNA was detected in 21/23 recurrences, corresponding to 91% sensitivity, including complete detection of T1, T2, and CIS and 83% detection of Ta tumors, with \\u003c1% false-negative results.\"},{\"question\":\"How could utDNA analysis change surveillance practices for patients?\",\"answer\":\"It showed potential to reduce the number of cystoscopies by 55%, benefiting 79% of patients, and it detected many recurrences earlier than cystoscopy.\"}]","Distinct longitudinal patterns of urine tumor DNA in patients undergoing surveillance for bladder cancer | PDF",1789993648]