[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-469236-105":59,"doc-detail-469236-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","disease-associated-adipose-browning-current-evidence-and-perspectives","Disease-associated adipose browning: current evidence and perspectives","","Brown and beige adipose tissue act as specialized thermogenic organs that evolved to help maintain body temperature. Decades of research indicate that white adipose tissue browning can increase energy expenditure, yet accumulating data show browning also arises in diverse chronic disease states. This review synthesizes findings from human diseases and animal models, including breast cancer, colorectal cancer, clear cell renal cell carcinoma, kidney health, burn injury, atherosclerosis, SARS-CoV-2, and sepsis. Adipose browning is consistently observed, but its pathological significance remains unresolved, including whether it is adaptive or a byproduct. Future work should define triggers and functional outcomes.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/disease-associated-adipose-browning-current-evidence-and-perspectives/469236/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/disease-associated-adipose-browning-current-evidence-and-perspectives/469236.png","ImageObject",300,407,{"name":92,"@type":93},"Jasmine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is adipose tissue browning and why is it important?","Question",{"text":113,"@type":114},"Brown adipose tissue and inducible beige adipose tissue function as thermogenic organs. Browning of white adipose tissue can increase energy expenditure and is linked to metabolic outcomes, making it important for understanding both benefits and risks in disease.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which diseases and models are covered in the review?",{"text":118,"@type":114},"The review summarizes pathological browning evidence in human diseases and animal models including breast cancer, colorectal cancer, clear cell renal cell carcinoma, kidney health, burn injury, atherosclerosis, SARS-CoV-2, and sepsis.",{"name":120,"@type":111,"acceptedAnswer":121},"What key question remains unresolved about disease-associated browning?",{"text":122,"@type":114},"It remains unclear whether pathological browning is a compensatory adaptive mechanism or merely a byproduct of disease progression. Future research is needed to identify triggers and determine functional outcomes.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},469236,1790815268,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":31,"preview_page_count":4},2336478487870,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","REVIEW ARTICLE     \nDisease-associated adipose browning: current evidence and perspectives  \nXiyue Zhang, Xue Han, Jiesi Xu and Guoping Li  \nThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, P.R. China  \nABSTRACT  \nBrown and beige adipose tissue represent evolutionary adaptations in mammals, functioning as specialized thermogenic organs to maintain body temperature. Over the past two decades, researches have demonstrated that white adipose tissue (WAT) browning is an effective strategy to enhance energy expenditure. However, a growing body of evidence indicates that the browning process frequently occurs in a variety of chronic disease states, though its pathophysiological significance remains unclear. This review summarized evidence of pathological browning observed in human diseases and animal models, including breast cancer, colorectal cancer (CRC), clear cell renal cell carcinoma (ccRCC), kidney health, burn injury, atherosclerotic, SARS-CoV-2 and sepsis. Despite distinct pathological contexts, adipose tissue browning is consistently observed. This suggests that browning may not simply serve its classical metabolically protective role, but instead reflect an atypical response to pathological stress. It is currently unclear whether this is a compensatory mechanism by the organism in a diseased state or merely a byproduct of the disease process. Whether this response is adaptive ora cause of disease progression remains unresolved. Future research should therefore focus on identifying the triggers and functional outcomes of pathological browning to better understand adipocyte plasticity and its role in disease progression.  \nARTICLE HISTORY  \nReceived 11 October 2025 Revised 4 December 2025 Accepted 23 December 2025  \nKEYWORDS  \nDisease-associated adipose browning; cancer; kidney health; burn injury; atherosclerosis  \n1. Introduction  \nBrown adipose tissue (BAT) and inducible beige adipose tissue (beige AT) residing within white adipose depots-collectively termed BAT-are key thermogenic organs that evolved in mammals as an adaptation to cold environments. They convert chemical energy into heat through uncoupling protein 1 (UCP1)-mediated non-shivering thermogenesis, protecting neonates and mammals from hypothermia [1,2] .  \nAlthough BAT was initially discovered as early as the 1950s, it was not until the early 21st century, with the identification of metabolically active BAT in adults [3], that a new era of research commenced. This era focused on harnessing BAT to increase energy expenditure and combat metabolic diseases. Over the past two decades, driven by the global epidemic of chronic metabolic disorders like obesity, mainstream scientific research has focused almost exclusively on the beneficial metabolic roles of BAT. These include enhancing energy expenditure, promoting glucose/lipid clearance, improving insulin sensitivity, and countering metabolic diseases [4–6] .  \nHowever, this therapeutic optimism may overlook a fundamental biological truth: physiological systems evolved for survival in ancestral environments may incur unintended adverse consequences in our modern context of energy abundance. Crucially, could the excessive or sustained activation of BAT thermogenesis become detrimental under specific physiological or pathological conditions?  \nWhile the metabolic benefits of adipose tissue browning have been extensively reviewed, a systematic analysis of its potential adverse consequences remains strikingly absent. A growing body of evidence indicates that the phenomenon of browning occurs in WAT under various pathological conditions. This review cautions against overstating the benefits of browning and emphasizes its impact on adipose metabolic homoeostasis, particularly in specific pathophysiological contexts.  \nCONTACT Xue Han  [hanxue5286","cbCaimNJfwyCCIVd","https://ap.wps.com/l/cbCaimNJfwyCCIVd","pdf",2499698,"English","# Introduction\n## Brown and beige adipose tissue as thermogenic organs\n## Therapeutic optimism and potential adverse consequences\n## Need for systematic review of adverse outcomes\n# Literature search and review rationale\n## Databases and search strategy\n## Inclusion and exclusion criteria\n# Pathological adip","[{\"question\":\"What is adipose tissue browning and why is it important?\",\"answer\":\"Brown adipose tissue and inducible beige adipose tissue function as thermogenic organs. Browning of white adipose tissue can increase energy expenditure and is linked to metabolic outcomes, making it important for understanding both benefits and risks in disease.\"},{\"question\":\"Which diseases and models are covered in the review?\",\"answer\":\"The review summarizes pathological browning evidence in human diseases and animal models including breast cancer, colorectal cancer, clear cell renal cell carcinoma, kidney health, burn injury, atherosclerosis, SARS-CoV-2, and sepsis.\"},{\"question\":\"What key question remains unresolved about disease-associated browning?\",\"answer\":\"It remains unclear whether pathological browning is a compensatory adaptive mechanism or merely a byproduct of disease progression. Future research is needed to identify triggers and determine functional outcomes.\"}]","Disease-associated adipose browning: current evidence and perspectives | PDF",1790775298]