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This study builds a systematic platform for discovering lead compounds against breast cancer using a traditional medical text. The workflow integrates text mining, 3-D virtual docking screening, and in vitro/in vivo validations. The analysis identified rutin as a specific historically cancer-used phytochemical, predicts EGFR blockade, and confirms significant anticancer effects in cell and recurrence models.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/discovering-the-anti-cancer-phytochemical-rutin-against-breast-cancer-through-the-methodical-platform-based-on-traditional-medicinal-knowledge/381897/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/discovering-the-anti-cancer-phytochemical-rutin-against-breast-cancer-through-the-methodical-platform-based-on-traditional-medicinal-knowledge/381897.png","ImageObject",300,407,{"name":92,"@type":93},"Bulrr","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the purpose of the study?","Question",{"text":112,"@type":113},"To build a systemic platform that uses traditional medical texts to develop lead phytochemical compounds against breast cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the researchers identify rutin for breast cancer targeting?",{"text":117,"@type":113},"They used text mining of traditional medical texts to identify rutin, then applied 3-D virtual docking screening to predict EGFR signaling blockade.",{"name":119,"@type":110,"acceptedAnswer":120},"What evidence supports rutin’s anticancer activity?",{"text":121,"@type":113},"In vitro experiments showed anticancer effects associated with EGFR pathway blockade, and in vivo models demonstrated anti-cancer effects using breast cancer recurrence models.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},381897,1790294004,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},5909892115043,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","BMB Reports  \nBMB Rep. 2023; 56(11): 594-599  \n[www.bmbreports.org](www.bmbreports.org)  \nDiscovering the anti-cancer phytochemical rutin against breast cancer through the methodical platform based on traditional medicinal knowledge  \nJungwhoi Lee1,\\#, *, Jungsul Lee2,\\#, WooGwang Sim2,3, Jae-Hoon Kim1, Chulhee Choi2,4, * & Jongwook Jeon5, *  \n1Department of Biotechnology, College of Applied Life Science, Jeju National University, Jeju 63243, 2Department of Bio and Brain Engineering, KAIST, Daejeon 34141, Korea, 3Department of Anatomy, University of California San Francisco, California 94143, USA, 4ILIAS Biologics Inc., Daejeon 34141, 5Korean Research Institute of Science Technology and Civilization, Jeonbuk National University, Jeonju 54932, Korea  \nA number of therapeutic drugs have been developed from functional chemicals found in plants. Knowledge of plants used for medicinal purposes has historically been transmitted by word of mouth or through literature. The aim of the present study is to provide a systemic platform for the development of lead compounds against breast cancer based on a traditional medical text. To verify our systematic approach, integrating processes consisted of text mining of traditional medical texts, 3-D virtual docking screening, and in vitro and in vivo experimental validations were demonstrated. Our text analysis system identified rutin as a specific phytochemical traditionally used for cancer treatment. 3-D virtual screening predicted that rutin could block EGFR signaling. Thus, we validated significant anticancer effects of rutin against breast cancer cells through blockade of EGFR signaling pathway in vitro. We also demonstrated in vivo anti-cancer effects of rutin using the breast cancer recurrence in vivo models. In summary, our innovative approach might be proper for discovering new phytochemical lead compounds designing for blockade of malignant neoplasm including breast cancer. [BMB Reports 2023; 56(11): 594-599]  \nINTRODUCTION  \nDrug development is a complex process that entails several disciplines in the selection of promising functional chemicals  \n*Corresponding authors. Jongwook Jeon, Tel: +82-63-270-5910; Fax:+82-63-270-5905; E-mail: [lovejnj@jbnu.ac.kr](lovejnj@jbnu.ac.kr); Jungwhoi Lee, Tel:+82-64-729-8556; Fax: +82-64-756-3351; E-mail: sdjd1108@kaist. [ac.kr](ac.kr); Chulhee Choi, Tel: +82-42-350-4321; Fax: +82-42-350-4380;  \nE-mail: [cchoi@iliasbio.com](cchoi@iliasbio.com)  \n\\#These authors contributed equally to this work. [https://doi.org/10.5483/BMBRep.2023-0057](https://doi.org/10.5483/BMBRep.2023-0057)  \nReceived 14 April 2023, Revised 16 May 2023, Accepted 21 June 2023, Published online 5 July 2023  \nKeywords: 3-D virtual screening, EGFR, In-silico, Medical classic, Rutin, Text-mining  \nand lead compounds (1) . High-throughput screening (HTS) that uses many chemicals synthesized from a pre-designed template is one typical method of identifying target chemicals within the biological area of interest (2) . As an alternative, there have been many drugs derived from phytochemicals of plants based on folk remedies, e.g., artemisinin against malaria, tamiflu for swine flu, and most famously, aspirin for relieving pain and reducing fever. Recent approaches for drug discovery have restrictively focused on specific diseases instead of historical records (3) .  \nThe study of folk therapy that uses readily available herbs is called ethnopharmacology (4) . Dongui-bogam (Treasured Mirror of Eastern Medicine, 1613), a traditional medical classic in Korea, and Bencao-gangmu (Compendium of Materia Medica, 1596), with nearly the same authority and status in China, are the most well-known sources of folk remedies. Both are registered with UNESCO. Dongui-bogam and Bencao-gangmu contain many ‘herb treatments’ (single herbs) or ‘formula prescriptions’(cocktails consisted of several relevant herbs) to treat pathological conditions. Inje-ji collection of benevolent cure is a part of Imwon-gyeong","cbCaicIbaN59Ogpj","https://ap.wps.com/l/cbCaicIbaN59Ogpj","pdf",6360128,"English","# Abstract\n# Introduction\n# Results\n## Systemic platform and text-mining workflow\n## Rutin selection and EGFR-mediated apoptosis","[{\"question\":\"What is the purpose of the study?\",\"answer\":\"To build a systemic platform that uses traditional medical texts to develop lead phytochemical compounds against breast cancer.\"},{\"question\":\"How did the researchers identify rutin for breast cancer targeting?\",\"answer\":\"They used text mining of traditional medical texts to identify rutin, then applied 3-D virtual docking screening to predict EGFR signaling blockade.\"},{\"question\":\"What evidence supports rutin’s anticancer activity?\",\"answer\":\"In vitro experiments showed anticancer effects associated with EGFR pathway blockade, and in vivo models demonstrated anti-cancer effects using breast cancer recurrence models.\"}]","Discovering the anti-cancer phytochemical rutin against breast cancer through the methodical platform based on traditional medicinal knowledge | PDF",1790247631,15]