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Significant differences are reported between normal and tumor samples, with ovarian and thyroid cancers showing the strongest contrasts. Low ABO expression is associated with reduced survival in several cancers, supporting ABO’s potential as a biomarker.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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Sciences (2024) 19(6), 1132e1142  \nOriginal Article  \nTaibah University  \nJournal of Taibah University Medical Sciences  \n[www.sciencedirect.com](www.sciencedirect.com)  \nDifferential expression of ABO in normal and tumor tissues: Implications for cancer biology and prognosis  \nHind M. Albadrani, PhDa, Munerah Hamed, PhD b, Abeer Zakariyah, PhDc, Samar Binkheder, PhD d, Saeed M. Kabrah, PhDe, * and Arwa F. Flemban, PhD b  \na Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Eastern Province, KSA  \nb Department of Pathology, Faculty of Medicine, Umm Al-Qura University, Makkah, KSA  \nc Department of Medical Genetics, Faculty of Medicine, University of Jeddah, Jeddah, KSA  \nd Medical Informatics Unit, Department of Medical Education, College of Medicine, King Saud University, Riyadh, KSAe Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, KSA  \nReceived 6 July 2024; revised 21 November 2024; accepted 4 December 2024  \nﺍﻟﻤﻠﺨﺺ  \nﺃﻫﺪﺍﻑ ﺍﻟﺒﺤﺚ: ﺗﻌﺮﻑ ﻓﺼﻴﻠﺔ ABO ﻓﻲ ﺍﻟﻤﻘﺎﻡ ﺍﻷﻭﻝ ﺑﺘﺤﺪﻳﺪ ﻓﺼﺎﺋﻞ ﺍﻟﺪﻡ،ﻭﺃﻇﻬﺮﺕ ﺍﻟﺪﺭﺍﺳﺎﺕ ﺃﻧﻤﺎﻁ ﺗﻌﺒﻴﺮ ﻣﺘﻐﻴﺮﺓ ﻓﻲ ﺍﻷﻧﺴﺠﺔ ﺍﻟﻤﺨﺘﻠﻔﺔ ﻭﺃﻧﻮﺍﻉ ﺍﻟﺴﺮﻃﺎﻥ.ﻭﺗﻬﺪﻑ ﻫﺬﻩ ﺍﻟﺪﺭﺍﺳﺔ ﺍﻟﺒﺤﺚ ﻓﻲ ﺍﻟﻌﻼﻗﺔ ﺑﻴﻦ ﺍﻟﺘﻌﺒﻴﺮ ﺍﻟﺠﻴﻨﻲ ﻟﻠﻔﺼﻴﻠﺔ ﻭﺍﻟﺴﺮﻃﺎﻥ،ﻭﺗﻘﻴﻴﻢ ﺗﺄﺛﻴﺮﻩ ﺍﻟﻤﺤﺘﻤﻞ ﻋﻠﻰ ﺑﻘﺎﺀ ﺍﻟﻤﺮﻳﺾ ﻋﻠﻰ ﻗﻴﺪ ﺍﻟﺤﻴﺎﺓ.  \nﻃﺮﻕ ﺍﻟﺒﺤﺚ: ﺑﺎﺳﺘﺨﺪﺍﻡ ﻗﺎﻋﺪﺓ ﺑﻴﺎﻧﺎﺕ GEPIA، ﻗﻤﻨﺎ ﺑﺘﺤﻠﻴﻞ ﺗﻌﺒﻴﺮ ABO ﻓﻲﺍﻷﻧﺴﺠﺔ ﺍﻟﻄﺒﻴﻌﻴﺔ ﻭﺍﻷﻭﺭﺍﻡ ﻋﺒﺮ ﺃﻧﻮﺍﻉ ﺍﻟﺴﺮﻃﺎﻥ ﺍﻟﻤﺨﺘﻠﻔﺔ ﺑﺎﺳﺘﺨﺪﺍﻡ ﺃﺩﻭﺍﺕ ﺍﻟﺘﺤﺎﻟﻴﻞﺍﻟﺠﻴﻨﻴﺔ ﺍﻟﻤﺘﺎﺣﺔ ﻋﺒﺮ ﺍﻹﻧﺘﺮﻧﺖ ﻹﺟﺮﺍﺀ ﺗﻘﻴﻴﻢ ﺷﺎﻣﻞ.  \nﺍﻟﻨﺘﺎﺋﺞ: ﻛﺸﻒ ﺍﻟﺘﺤﻠﻴﻞ ﻋﻦ ﺗﺒﺎﻳﻨﺎﺕ ﻛﺒﻴﺮﺓ ﻓﻲ ﺍﻟﺘﻌﺒﻴﺮ ﻋﻦ ABO ﺑﻴﻦ ﺃﻧﻮﺍﻉﺍﻷﻧﺴﺠﺔ ﺍﻟﻤﺨﺘﻠﻔﺔ. ﻭﺍﻟﺠﺪﻳﺮ ﺑﺎﻟﺬﻛﺮ ﺃﻥ ﺃﻧﺴﺠﺔ ﺍﻟﻤﺒﻴﺾ ﻭﺍﻟﻐﺪﺓ ﺍﻟﺪﺭﻗﻴﺔ ﺃﻇﻬﺮﺕ ﺃﻋﻠﻰﺗﻌﺒﻴﺮ ﻋﻦ ABO، ﻓﻲ ﺣﻴﻦ ﺃﻇﻬﺮﺕ ﺃﻧﺴﺠﺔ ﺍﻟﻜﺒﺪ ﻭﺍﻟﻐﺪﺓ ﺍﻟﺼﻌﺘﺮﻳﺔ ﻭﺍﻟﺪﻣﺎﻍ ﺗﻌﺒﻴﺮً ﺍﻣﻨﺨﻔﻀً ﺎ ﻧﺴﺒﻴً ﺎ. ﻭﺗﺒﺎﻳﻨﺖ ﺃﻧﻤﺎﻁ ﺍﻟﺘﻌﺒﻴﺮ ﻋﻦ ABO ﺑﺸﻜﻞ ﻭﺍﺿﺢ ﺑﻴﻦ ﺃﻧﻮﺍﻉﺍﻟﺴﺮﻃﺎﻥ، ﺣﻴﺚ ﺃﻇﻬﺮﺕ ﺳﺮﻃﺎﻧﺎﺕ ﺍﻟﻤﺒﻴﺾ ﻭﺍﻟﻐﺪﺓ ﺍﻟﺪﺭﻗﻴﺔ ﺍﻻﺧﺘﻼﻓﺎﺕ ﺍﻷﻛﺜﺮﺃﻫﻤﻴﺔ ﺑﻴﻦ ﺃﻧﺴﺠﺔ ﺍﻟﻮﺭﻡ ﻭﺍﻷﻧﺴﺠﺔ ﺍﻟﻄﺒﻴﻌﻴﺔ. ﻛﻤﺎ ﺃﻇﻬﺮﺕ ﺃﻧﻮﺍﻉ ﺃﺧﺮﻯ ﻣﻦﺍﻟﺴﺮﻃﺎﻥ، ﺑﻤﺎ ﻓﻲ ﺫﻟﻚ ﺳﺮﻃﺎﻥ ﻗﺸﺮﺓ ﺍﻟﻜﻈﺮ، ﻭﺳﺮﻃﺎﻥ ﺍﻟﺪﻡ ﺍﻟﻨﻘﻮﻱ ﺍﻟﺤﺎﺩ،ﻭﺳﺮﻃﺎﻥ ﺍﻟﺨﻼﻳﺎ ﺍﻟﻜﻠﻮﻳﺔ، ﺍﺧﺘﻼﻓﺎﺕ ﻣﻠﺤﻮﻇﺔ ﻓﻲ ﺍﻟﺘﻌﺒﻴﺮ ﻋﻦ ABO. ﻭﺍﺭﺗﺒﻂﺍﻧﺨﻔﺎﺽ ﺍﻟﺘﻌﺒﻴﺮ ﻋﻦ ABO ﺑﺎﻧﺨﻔﺎﺽ ﻣﻌﺪﻻﺕ ﺍﻟﺒﻘﺎﺀ ﻋﻠﻰ ﻗﻴﺪ ﺍﻟﺤﻴﺎﺓ ﻓﻲ ﺳﺮﻃﺎﻥﺍﻟﻐﺪﺓ ﺍﻟﺪﺭﻗﻴﺔ ﺍﻟﻘﻮﻟﻮﻥ ﻭﺍﻟﻤﺴﺘﻘﻴﻢ، ﻭﺳﺮﻃﺎﻥ ﺍﻟﻐﺪﺓ ﺍﻟﺪﺭﻗﻴﺔ ﻓﻲ ﺍﻟﻤﻌﺪﺓ، ﻭﺳﺮﻃﺎﻧﺎﺕﺍﻟﻜﻠﻰ، ﻭﻏﻴﺮﻫﺎ.  \n* Corresponding address: Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, KSA.  \nE-mail: [smkabrah@uqu.edu.sa](smkabrah@uqu.edu.sa) (S.M. Kabrah) Peer review under responsibility of Taibah University.  \n\n| \u003Cbr>| Production and hosting by Elsevier |\n| --- | --- |\n\nﺍﻻﺳﺘﻨﺘﺎﺟﺎﺕ: ﺗﺸﻴﺮ ﻫﺬﻩ ﺍﻟﻨﺘﺎﺋﺞ ﺇﻟﻰ ﺍﻟﺪﻭﺭ ﺍﻟﻤﺤﺘﻤﻞ ﻟـ ABO ﻓﻲ ﺗﻄﻮﺭ ﺍﻟﻮﺭﻡﻭﺗﻄﻮﺭ ﺍﻟﺴﺮﻃﺎﻥ ﻭﺍﻟﺘﺸﺨﻴﺺ. ﻛﻤﺎ ﺗﺆﻛﺪ ﻫﺬﻩ ﺍﻟﺪﺭﺍﺳﺔ ﻋﻠﻰ ﻗﻴﻤﺔ ABO ﻛﻤﺆﺷﺮﺣﻴﻮﻱ ﻟﻤﺨﺘﻠﻒ ﺃﻧﻮﺍﻉ ﺍﻟﺴﺮﻃﺎﻥ ﻭﺗﺘﻄﻠﺐ ﺇﺟﺮﺍﺀ ﺍﻟﻤﺰﻳﺪ ﻣﻦ ﺍﻟﺒﺤﺚ ﻟﻔﻬﻢ ﺃﺩﻭﺍﺭﻩﺍﻟﻮﻇﻴﻔﻴﺔ ﻭﺗﺄﺛﻴﺮﺍﺗﻪ ﺍﻟﻌﻼﺟﻴﺔ ﻟﺘﻄﻮﻳﺮ ﻋﻼﺟﺎﺕ ﺍﻟﺴﺮﻃﺎﻥ ﺍﻟﻤﺴﺘﻬﺪﻓﺔ ﻭﺃﺩﻭﺍﺕﺍﻟﺘﺸﺨﻴﺺ.  \nﺍﻟﻜﻠﻤﺎﺕ ﺍﻟﻤﻔﺘﺎﺣﻴﺔ: ﻓﺼﻴﻠﺔ ABO؛ ﺍﻟﺘﻌﺒﻴﺮ ﺍﻟﺠﻴﻨﻲ؛ ﺳﺮﻃﺎﻥ؛ ﻭﺭﻡ؛ ﺗﺤﻠﻴﻞﺍﻟﺴﻴﻠﻴﻜﻮ  \nAbstract  \nObjectives: ABO, which is primarily recognized for determining blood types, shows variable expression patterns in different tissues and cancer types. This study investigated the relationship between gene expression and cancer, and assessed its potential impact on patient survival.  \nMethods: Utilizing the GEPIA database, we analyzed ABO expression in normal and tumor tissues across various cancer types using online in silico tools for comprehensive evaluation.  \nResults: The analysis revealed significant disparities in ABO expression among different tissue types. Notably, ovarian and thyroid tissues exhibited the highest expression of ABO, whereas the liver, thymus, and brain tissues showed relatively low expression. The expression patterns of ABO varied distinctly among cancer types, with ovarian and thyroid carcinomas demonstrating the most significant differences between tumor and normal tissues. Other cancers, including adrenocortical carcinoma, acute  \n1658-3612 􀀁 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license ([h","cbCaih2drvtNLNJg","https://ap.wps.com/l/cbCaih2drvtNLNJg","pdf",3392352,11,"English","# Abstract\n## Objectives\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What is the main purpose of the study on ABO expression?\",\"answer\":\"To examine how ABO gene expression varies across normal and tumor tissues and to evaluate its potential relationship with cancer progression and patient survival.\"},{\"question\":\"What tools and data are used to analyze ABO expression?\",\"answer\":\"The study uses the GEPIA database and online in silico tools to evaluate ABO expression across different tissue types and cancer types.\"},{\"question\":\"Which tissue types and cancer types show the largest differences in ABO expression?\",\"answer\":\"Ovarian and thyroid tissues show the highest ABO expression, and ovarian and thyroid carcinomas demonstrate the most significant differences between tumor and normal tissues.\"}]","Differential expression of ABO in normal and tumor tissues - Implications for cancer biology and prognosis | PDF",1790000092,28]