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Patients undergoing surgery from January 2009 to December 2019 were included based on molecular pathology reports. Among 2203 cases, KRAS codons 12, 13, and 61 mutations occurred at 27.7%, 9.1%, and 1.3%. Codon 12 correlated with pathological and recurrence-risk variables, while codon 13 showed no significant clinicopathological associations. Multivariable Cox regression identified codon 12 as an independent recurrence risk factor.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/different-oncological-features-of-colorectal-cancer-codon-specific-kras-mutations-not-codon-13-but-codon-12-have-prognostic-value/381620/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/different-oncological-features-of-colorectal-cancer-codon-specific-kras-mutations-not-codon-13-but-codon-12-have-prognostic-value/381620.png","ImageObject",300,407,{"name":92,"@type":93},"Nguyễn Văn Học","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study aim regarding KRAS mutations in colorectal cancer?","Question",{"text":112,"@type":113},"To assess clinicopathological characteristics and the prognostic value of codon-specific KRAS mutations, with particular attention to codon 13.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients selected in the retrospective cohort?",{"text":117,"@type":113},"Patients with stage I-III colorectal cancer who underwent surgery between January 2009 and December 2019 were included, provided their KRAS mutation status was confirmed by molecular pathology reports.",{"name":119,"@type":110,"acceptedAnswer":120},"Which KRAS codon showed independent prognostic relevance for recurrence?",{"text":121,"@type":113},"Codon 12 was identified as an independent risk factor for recurrence in multivariable analysis, while codon 13 was less likely to serve as a prognostic biomarker.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},381620,1790483983,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374402739827,"https://ap-avatar.wpscdn.com/avatar/14000c97e7351f1a627?x-image-process=image/resize,m_fixed,w_180,h_180&k=1787885694763230660","| W | J | G | World Journal of\u003Cbr>Gastroenterology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2023 August 28; 29(32): 4883-4899  \nDOI: 10.3748/wjg.v29.i32.4883 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nORIGINAL ARTICLE  \nRetrospective Cohort Study  \nDifferent oncological features of colorectal cancer codon-specific KRAS mutations: Not codon 13 but codon 12 have prognostic value  \nHong-Min Ahn, Duck-Woo Kim, Hyeon Jeong Oh, Hyung Kyung Kim, Hye Seung Lee, Tae Gyun Lee, Hye-Rim Shin, In Jun Yang, Jeehye Lee, Jung Wook Suh, Heung-Kwon Oh, Sung-Bum Kang  \nSpecialty type: Oncology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): B  \nGrade C (Good): C, C  \nGrade D (Fair): 0  \nGrade E (Poor): 0  \nP-Reviewer: Malekpour A, Iran; Wang XL, China; Xie Q, China  \nReceived: May 20, 2023  \nPeer-review started: May 20, 2023  \nFirst decision: June 22, 2023  \nRevised: July 6, 2023  \nAccepted: July 31, 2023  \nArticle in press: July 31, 2023  \nPublished online: August 28, 2023  \nHong-Min Ahn, Duck-Woo Kim, Tae Gyun Lee, Hye-Rim Shin, In Jun Yang, Jeehye Lee, Jung Wook Suh, Heung-Kwon Oh, Sung-Bum Kang, Department of Surgery, Seoul National University Bundang Hospital, Seongnam 13620, South Korea  \nHyeon Jeong Oh, Hyung Kyung Kim, Department of Pathology, Seoul National University Bundang Hospital, Seongnam 13620, South Korea  \nHye Seung Lee, Department of Pathology, Seoul National University Hospital, Seoul 03080, South Korea  \nCorresponding author: Duck-Woo Kim, MD, PhD, Professor, Department of Surgery, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, Seongnam 13620, South [Korea.](Korea. kdw@snubh.org)[ kdw@snubh.org](Korea. kdw@snubh.org)  \nAbstract  \nBACKGROUND  \nApproximately 40% of colorectal cancer (CRC) cases are linked to Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations. KRAS mutations are associated with poor CRC prognosis, especially KRAS codon 12 mutation, which is associated with metastasis and poorer survival. However, the clinicopathological characteristics and prognosis of KRAS codon 13 mutation in CRC remain unclear.  \nAIM  \nTo evaluate the clinicopathological characteristics and prognostic value of codonspecific KRAS mutations, especially in codon 13.  \nMETHODS  \nThis retrospective, single-center, observational cohort study included patients who underwent surgery for stage I-III CRC between January 2009 and December 2019. Patients with KRAS mutation status confirmed by molecular pathology reports were included. The relationships between clinicopathological characteristics and individual codon-specific KRAS mutations were analyzed. Survival data were analyzed to identify codon-specific KRAS mutations as recurrence-related factors using the Cox proportional hazards regression model.  \nRESULTS  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 4883 August 28, 2023  Volume 29  Issue 32   \nAhn HM et al. Codon-specific KRAS mutation in CRC  \nAmong the 2203 patients, the incidence of KRAS codons 12, 13, and 61 mutations was 27.7%, 9.1%, and 1.3%, respectively. Both KARS codons 12 and 13 mutations showed a tendency to be associated with clinical characteristics, but only codon 12 was associated with pathological features, such as stage of primary tumor (T stage), lymph node involvement (N stage), vascular invasion, perineural invasion, tumor size, and microsatellite instability. KRAS codon 13 mutation showed no associations (77.2% vs 85.3%, P = 0.159), whereas codon 12 was associated with a lower 5-year recurrence-free survival rate (78.9% vs 75.5%, P = 0.025). In multivariable analysis, along with T and N stages and vascular and perineural invasion, only codon 12 (hazard ratio: 1.399; 95% confidence interval: 1.034-1.894; P = 0.030) amon","cbCaijEwYqlsFm0I","https://ap.wps.com/l/cbCaijEwYqlsFm0I","pdf",1696539,18,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusion\n# Key Words","[{\"question\":\"What was the study aim regarding KRAS mutations in colorectal cancer?\",\"answer\":\"To assess clinicopathological characteristics and the prognostic value of codon-specific KRAS mutations, with particular attention to codon 13.\"},{\"question\":\"How were patients selected in the retrospective cohort?\",\"answer\":\"Patients with stage I-III colorectal cancer who underwent surgery between January 2009 and December 2019 were included, provided their KRAS mutation status was confirmed by molecular pathology reports.\"},{\"question\":\"Which KRAS codon showed independent prognostic relevance for recurrence?\",\"answer\":\"Codon 12 was identified as an independent risk factor for recurrence in multivariable analysis, while codon 13 was less likely to serve as a prognostic biomarker.\"}]","Different oncological features of colorectal cancer codon-specific KRAS mutations - Not codon 13 but codon 12 have prognostic value | PDF",1790246165,45]