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Those models incorporate age, which itself strongly drives cognitive impairment, and may diverge from objective measures of GFR. This study compares eGFR with measured GFR (mGFR) in 368 African American older adults, relating both kidney measures to memory and executive function while assessing regression effects with age and sex adjustment.",{"@graph":69,"@context":114},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/differences-in-estimated-vs-measured-gfr-associations-with-cognitive-function-in-african-american-older-adults/427384/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/differences-in-estimated-vs-measured-gfr-associations-with-cognitive-function-in-african-american-older-adults/427384.png","ImageObject",300,407,{"name":92,"@type":93},"Oliver","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-21","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main finding after adjusting for age and sex?","Question",{"text":112,"@type":113},"In unadjusted models, eGFR showed positive associations with DSST and RAVLT, while mGFR had only marginal associations. Adjusting for age and sex greatly attenuated all associations, suggesting age may explain much of the previously reported links.","Answer","https://schema.org",{"og:url":83,"og:type":116,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":118,"canonical":83},"index,follow",{"doc_id":120,"site_id":62},427384,1790765481,{"code":4,"msg":5,"data":123},{"doc_id":120,"user_id":124,"nickname":92,"user_avatar":125,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":126,"file_id":127,"file_url":128,"file_type":129,"file_size":130,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":131,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":132,"faqs":133,"seo_title":134,"seo_description":67,"update_tm":135,"read_time":81},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Innovation in Aging, 2025, Vol. 9, No. S2 857  \nAbstract citation ID: igaf122.2902  \nDIFFERENCES IN ESTIMATED VS MEASURED GFR ASSOCIATIONS WITH COGNITIVE FUNCTION IN AFRICAN AMERICAN OLDER ADULTS  \nHarshin Sanjanwala1, Xiaoqian Zhu2, B. Gwen Windham2, Srishti Shrestha2, Michael Griswold2, Andrew Rule3, Thomas Mosley2, and Kevin Sullivan2, 1. University of Mississippi Medical Center, Jackson, Mississippi, United States, 2.  \nUniversity of Mississippi Medical Center-The MIND Center, Jackson, Mississippi, United States, 3. Mayo Clinic, Rochester, Minnesota, United States  \nImpaired kidney function is a risk factor for cognitive decline and dementia, but most studies use serum creatinine-based equations to estimate kidney function as estimated glomerular filtration rate (eGFR); these equations include age, also a strong driver of cognitive impairment, and produce eGFR estimates with substantial error compared to gold-standard objective measures of GFR (mGFR). The purpose of this study was to determine eGFRand mGFR associations with cognitive function in African American adults, a population disproportionately impacted by both chronic kidney disease and dementia. We conducted across-temporal analysis of 368 participants (Age: 66.4 ± 7.4y, 75% Female) in the Genetic Epidemiology Network of Arteriopathy study with eGFR (CKD-EPI 2021 Creatinine Race-Free Equation) and mGFR assessed. eGFR was assessed using the CKD-EPI 2021 Creatinine Race-Free Equation and mGFR (urinary clearance of non-radiolabeled iothalamate) . Memory (Rey Auditory Verbal Learning Test; RAVLT) and executive function (Digit Symbol Substitution Test; DSST) were assessed. Linear regression models were used to relate eGFR, mGFR, and serum creatinine to cognitive function with and without adjustment for age and sex. In unadjusted models, eGFR was positively associated with DSST scores (β = 0.19, 95%CI:0.11, 0.27) and RAVLT scores (β = 0.10, 95%CI:0.04, 0.16) . mGFR was marginally associated with DSST scores (β = 0.07, 95%CI:- 0.00, 0.14), but not RAVLT scores (β = 0.03, 95%CI:-0.01, 0.07) . Associations of serum creatinine with cognitive function were mostly null to marginal. Age and sex adjustment greatly attenuated all associations. The observed differential renal function associations with cognition suggest age may largely explain prior reported associations.","cbCaisxTewC1Y1r1","https://ap.wps.com/l/cbCaisxTewC1Y1r1","pdf",775003,"English","# Abstract\n## Study purpose and rationale\n## Methods and assessments\n## Results and interpretation","[{\"question\":\"What was the main finding after adjusting for age and sex?\",\"answer\":\"In unadjusted models, eGFR showed positive associations with DSST and RAVLT, while mGFR had only marginal associations. Adjusting for age and sex greatly attenuated all associations, suggesting age may explain much of the previously reported links.\"}]","DIFFERENCES IN ESTIMATED VS MEASURED GFR ASSOCIATIONS WITH COGNITIVE FUNCTION IN AFRICAN AMERICAN OLDER ADULTS | PDF",1790643697]