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Gastric cancer lesions from patients completing HPE and undergoing upper gastrointestinal endoscopy between January 2004 and March 2016 were analyzed using univariate and multiple logistic methods. Findings show higher rates of depressed-type tumors and sub-submucosal invasion in UGC, with female sex and absent follow-up as independent risks.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/differences-in-clinical-features-and-morphology-between-differentiated-and-undifferentiated-gastric-cancer-after-helicobacter-pylori-eradication/385653/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/differences-in-clinical-features-and-morphology-between-differentiated-and-undifferentiated-gastric-cancer-after-helicobacter-pylori-eradication/385653.png","ImageObject",300,407,{"name":42,"@type":43},"Eliana","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",14,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the study comparing?","Question",{"text":63,"@type":64},"The study compares clinicopathologic characteristics of undifferentiated gastric cancer (UGC) versus differentiated gastric cancer (DGC) diagnosed after successful Helicobacter pylori eradication (HPE).","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were patients selected for analysis?",{"text":68,"@type":64},"Gastric cancer lesions from patients who completed successful HPE and underwent upper gastrointestinal endoscopy at specified hospitals from January 2004 to March 2016 were analyzed.",{"name":70,"@type":61,"acceptedAnswer":71},"Which factors were identified as independent risks for post-HPE UGC?",{"text":72,"@type":64},"Female sex and absent follow-up were significant independent risk factors for UGC after HPE.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},385653,1790464107,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","PLOS ONE  \nOPEN ACCESS  \nCitation: Kodama M, Mizukami K, Hirashita Y, Okimoto T, Wada Y, Fukuda M, et al. (2023) Differences in clinical features and morphology between differentiated and undifferentiated gastric cancer after Helicobacter pylori eradication. PLoSONE 18(3): e0282341 . [https://doi.org/10.1371/](https://doi.org/10.1371/)[ ](https://doi.org/10.1371/)[journal.pone.0282341](journal.pone.0282341)  \nEditor: Alejandro Piscoya, Hospital Guillermo Kaelin de la Fuente, PERU  \nReceived: August 19, 2022  \nAccepted: February 12, 2023  \nPublished: March 31, 2023  \nCopyright: © 2023 Kodama et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nData Availability Statement: All relevant data are within the paper.  \nFunding: This work was supported by JSPSKAKENHI Grant Number JP 26460942 and JP 18K07946 . The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.  \nCompeting interests: The authors have declared that no competing interests exist.  \nRESEARCH ARTICLE  \nDifferences in clinical features and morphology between differentiated and undifferentiated gastric cancer after Helicobacter pylori eradication  \nMasaaki Kodama1,2 *, Kazuhiro Mizukami1, Yuka Hirashita1, Tadayoshi Okimoto1, Yasuhiro Wada1, Masahide Fukuda1, Sotaro Ozaka1, Yoko Kudo1, Kanako Ito1, Ryo Ogawa1, Kazuhisa Okamoto1, Kensuke Fukuda1, Kazunari Murakami1  \n1 Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan, 2 Faculty of Welfare and Health Science, Oita University, Oita, Japan  \n* [kodm@oita-u.ac.jp](kodm@oita-u.ac.jp)  \nAbstract  \nBackground/Aims  \nAlthough undifferentiated gastric cancer (UGC) diagnosed after Helicobacter pylori eradication (HPE) carries a poor prognosis, characteristics of post-HPE UGC have not been evaluated in detail because of its low incidence. Therefore, we compared the clinicopathologic characteristics of UGC and differentiated gastric cancers (DGC) diagnosed after successful HPE.  \nMethods  \nGC lesions from patients who had successfully completed HPE and who had undergone upper gastrointestinal endoscopy between January 2004 and March 2016 were analyzed. Tumors were divided into DGC and UGC groups. Clinicopathologic factors of background and tumor characteristics were compared using univariate and multiple logistic analyses.  \nResults  \nA total of 129 tumors from 115 patients were evaluated; 113 tumors were in the DGC group and 16 in the UGC group. Depressed-type tumors (P = 0.024) and sub-submucosal invasion (P\u003C0.001) were significantly higher in the UGC group. The UGC group had larger tumor diameters (25 .9±7.3 mm) than the DGC group (13 .2±10.2 mm) (P\u003C0.001) . Multivariate analysis showed that female sex (odds ratio [OR] 3 .24, 95%CI:1 .02–10.37; P = 0.047) and absent follow-up (OR 4 .99, 95%CI:1 .60–15.57; P = 0.006) were significant independent risk factors for UGC. The DGC group showed a gradually decreasing temporal trend by trend test (P = 0.015), while the UGC group showed a relatively constant incidence over time, although the number of cases was small.  \nConclusion  \nUGC was diagnosed even after long time spans following HPE, although the number of cases was small. Female sex, and especially absent follow-up, were risks for post-HPEUGC, suggesting that diligent long-term follow-up after HPE is essential.  \nIntroduction  \nHelicobacter pylori is a well-known etiologic agent of many gastric mucosal diseases, such as chronic active gastritis, gastric atrophy, intestinal metaplasia, and finally gastric cancer (GC)  \n[ 1]. H. pylori is a most important carcinogen of GC. The World Health Organization’s International Agency for Research on Cancer Working Group (IARC) recognized that H. pylori causes almost 90% of non-cardia GC [2] . Recent advan","cbCaif3AuRKdv7f3","https://ap.wps.com/l/cbCaif3AuRKdv7f3","pdf",1360120,15,"English","# Abstract\n## Background/Aims\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Methods\n## Subjects","[{\"question\":\"What is the study comparing?\",\"answer\":\"The study compares clinicopathologic characteristics of undifferentiated gastric cancer (UGC) versus differentiated gastric cancer (DGC) diagnosed after successful Helicobacter pylori eradication (HPE).\"},{\"question\":\"How were patients selected for analysis?\",\"answer\":\"Gastric cancer lesions from patients who completed successful HPE and underwent upper gastrointestinal endoscopy at specified hospitals from January 2004 to March 2016 were analyzed.\"},{\"question\":\"Which factors were identified as independent risks for post-HPE UGC?\",\"answer\":\"Female sex and absent follow-up were significant independent risk factors for UGC after HPE.\"}]","Differences in clinical features and morphology between differentiated and undifferentiated gastric cancer after Helicobacter pylori eradication | PDF",1790270422,38]