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This retrospective single-center analysis compared 179 newly diagnosed laryngopharyngeal squamous cell carcinoma lesions from 2016–2020, separating 74 missed and 105 detected cases. Missed cancers were associated with lower use of pethidine hydrochloride, reduced narrow-band imaging, and more negative comprehensiveness scores, with epiglottic tumor location showing an excess.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/differences-in-clinical-characteristics-between-missed-and-detected-laryngopharyngeal-cancers/366343/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/differences-in-clinical-characteristics-between-missed-and-detected-laryngopharyngeal-cancers/366343.png","ImageObject",300,407,{"name":92,"@type":93},"McQueen","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How were missed and detected laryngopharyngeal cancers defined in the study?","Question",{"text":112,"@type":113},"Missed cancers were identified within 18 months of a preceding esophagogastroduodenoscopy, while detected cancers were not included in the missed group.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which factors were significantly associated with missed cancers in multivariate analysis?",{"text":117,"@type":113},"Lower non-use rate of pethidine hydrochloride, higher use of narrow-band imaging during laryngopharynx observation, and a higher number of negative “comprehensiveness of laryngopharyngeal observation” items were associated with missed cases.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study conclude about how to reduce missed cancers?",{"text":121,"@type":113},"Precise laryngopharyngeal observation using narrow-band imaging and premedication, along with attention to epiglottic lesions, may reduce missed cancer frequency.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},366343,1790535543,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},5909890329169,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Journal of Gastroenterology and Hepatology  \nDifferences in Clinical Characteristics Between Missed and Detected Laryngopharyngeal Cancers  \nYusuke Kumazawa1  | Yohei Ikenoyama1,2 | Manabu Takamatsu3,4 | Koyo Kido1,2 | Ken Namikawa1  | Yoshitaka Tokai1  | Shoichi Yoshimizu1 | Yusuke Horiuchi1  | Akiyoshi Ishiyama1  | Toshiyuki Yoshio1  | Toshiaki Hirasawa1 | Akira Seto5 | Takashi Toshiyasu6 | Shunji Takahashi7 | Junko Fujisaki1  \n1Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan | 2Department of Gastroenterology and Hepatology, Mie University Hospital, Tsu, Mie, Japan | 3Department of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan | 4Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan | 5Department of Head and Neck Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan | 6Department of Radiation Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan | 7Department of Medical Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan  \nCorrespondence: Yohei Ikenoyama ([yohei.ikenoyama@jfcr.or.jp](yohei.ikenoyama@jfcr.or.jp))  \nReceived: 28 January 2025 | Revised: 9 May 2025 | Accepted: 16 May 2025  \nFunding: The authors received no specific funding for this work.  \nKeywords: cancer | endoscopy | laryngopharyngeal squamous cell carcinoma | narrow-band imaging  \nABSTRACT  \nBackground and aim: Laryngopharyngeal cancers are often overlooked during endoscopy because of their anatomical complexity and the gag reflex. However, the characteristics of these cancers remain poorly understood. We studied the differences in clinical characteristics and endoscopic procedures between missed and detected cancers.  \nMethods: Newly diagnosed laryngopharyngeal squamous cell carcinomas identified during esophagogastroduodenoscopy at our hospital between January 2016 and December 2020 were analyzed. A total of 179 lesions were categorized into two groups: missed (n = 74) and detected (n = 105). Missed cancer was defined as a lesion identified within 18 months of preceding esophagogastroduodenoscopy at our hospital, while detected cancer was defined as a lesion not included in the missed group.  \nResults: The miss rate oflaryngopharyngeal cancers on esophagogastroduodenoscopy was 41.3% . Multivariate analysis showed that the non-use rate of pethidine hydrochloride (odds ratio 4.1, 95% confidence interval 2.0–8.6, p \u003C 0.01), ratio of white-light imaging ≥ narrow-band imaging through observation of laryngopharynx (odds ratio 31.8, 95% confidence interval 3.9–258.0, p \u003C 0.01), and number of “comprehensiveness of laryngopharyngeal observation” negatives (odds ratio 2.6, 95% confidence interval 1.3–5.4, p = 0.01) were significantly larger in the missed group. Univariate analysis showed that the number of tumors located on the epiglottis (p = 0.02) was significantly larger in the missed group.  \nConclusions: This study highlights the importance of precisely observing the laryngopharynx, facilitated by the use of pethidine hydrochloride and narrow-band imaging. In addition, epiglottic lesions are frequently missed. Comprehensive observation ofthe laryngopharynx using narrow-band imaging and premedication may reduce the frequency of missed cancers.  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.  \n© 2025 The Author(s). Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.  \nJournal of Gastroenterology and Hepatology, 2025; 40:2037–2045 2037  \n[https://doi.org/10.1111/jgh.17023](http","cbCaik2WahvdvPN0","https://ap.wps.com/l/cbCaik2WahvdvPN0","pdf",1732321,"English","# Abstract\n# Introduction\n# Methods\n## Participants","[{\"question\":\"How were missed and detected laryngopharyngeal cancers defined in the study?\",\"answer\":\"Missed cancers were identified within 18 months of a preceding esophagogastroduodenoscopy, while detected cancers were not included in the missed group.\"},{\"question\":\"Which factors were significantly associated with missed cancers in multivariate analysis?\",\"answer\":\"Lower non-use rate of pethidine hydrochloride, higher use of narrow-band imaging during laryngopharynx observation, and a higher number of negative “comprehensiveness of laryngopharyngeal observation” items were associated with missed cases.\"},{\"question\":\"What did the study conclude about how to reduce missed cancers?\",\"answer\":\"Precise laryngopharyngeal observation using narrow-band imaging and premedication, along with attention to epiglottic lesions, may reduce missed cancer frequency.\"}]","Differences in Clinical Characteristics Between Missed and Detected Laryngopharyngeal Cancers | PDF",1790164922,23]