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A cross-sectional analysis used NHANES 2011–2014, the only public period with objective cognitive assessments, to define impairment. The study modeled the number of prescription medications as the outcome, with supplement use as the primary predictor and demographics and comorbidities as covariates. Results showed higher mean medication counts in supplement users, with a significant association that attenuated after adjustment, underscoring the need for medication-safety recognition and further research.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/dietary-supplement-and-prescription-medication-use-among-older-adults-with-cognitive-impairment-research-paper-summary/427703/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/dietary-supplement-and-prescription-medication-use-among-older-adults-with-cognitive-impairment-research-paper-summary/427703.png","ImageObject",300,407,{"name":92,"@type":93},"Kyle","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-06","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What question does the study address?","Question",{"text":112,"@type":113},"The study examines whether dietary supplement use is associated with prescription medication use among older adults with cognitive impairment and how this may contribute to medication burden.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which dataset and time period were used to define cognitive impairment?",{"text":117,"@type":113},"NHANES 2011–2014 was selected because it contains objective cognitive measurements (Cognitive Functioning Assessment) for identifying impairment.",{"name":119,"@type":110,"acceptedAnswer":120},"How was the relationship between supplement use and prescription medication use tested?",{"text":121,"@type":113},"Design-adjusted t-tests and Rao–Scott tests compared users vs. non-users, and negative binomial regression evaluated associations with the number of prescription medications while adjusting for covariates.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},427703,1790878021,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},3985741905716,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","758 Innovation in Aging, 2025, Vol. 9, No. S2  \nadults with cognitive impairment (based on 1,567 NHANES respondents), an estimated 65.6% used dietary supplements. Supplement users took more prescription medications on average than non-users (4.8 vs. 4.2, p = 0.036) . Supplement use was significantly associated with increased prescription medication use (estimated rate ratio = 1. 14, 95% CI 1.01–1.29), but not after adjustment for covariates. Given the adverse outcomes of increased medication use, recognizing supplement use in older adults with cognitive impairment is suggested for medication safety. Further research is needed to clarify supplements’ role in medication burden.  \nAbstract citation ID: igaf122.2576  \nDIETARY SUPPLEMENT AND PRESCRIPTION  \nMEDICATION USE AMONG OLDER ADULTS WITH  \nCOGNITIVE IMPAIRMENT.  \nHao-Ping Chiang, Brady West, and Antoinette Coe, University of Michigan, Ann Arbor, Michigan, United States  \nSupplement use among older adults is associated with higher prescription medication use, leading to medication harm and hospitalizations. As patients with cognitive impairment are vulnerable to polypharmacy and these adverse outcomes, it’s essential to understand how supplement use contributes to medication burden. This cross-sectional study examined the association between dietary supplement and prescription medication use among U.S. adults aged 60 and older with cognitive impairment, using the National Health and Nutrition Examination Survey (NHANES). NHANES 2011–2014 was selected as the only publicly available period with objective cognitive measurements (Cognitive Functioning Assessment) for defining impairment. The outcome was the number of prescription medications. The primary predictor was dietary supplement use (yes/no) . Covariates included age, sex, race, education, insurance, and comorbidities.  \nMean and proportion differences between supplement users and non-users were analyzed using design-adjusted t-tests and Rao–Scott tests. Negative binomial regression models evaluated associations between the predictor variables and the number of prescription medications. Among an estimated 20,939,624 older","cbCaitmDaWklrxsd","https://ap.wps.com/l/cbCaitmDaWklrxsd","pdf",684450,"English","# Study overview\n## Objective, design, and data source\n## Population and impairment definition\n## Variables, covariates, and outcomes\n# Methods and statistical analysis\n## Group comparisons\n## Regression modeling","[{\"question\":\"What question does the study address?\",\"answer\":\"The study examines whether dietary supplement use is associated with prescription medication use among older adults with cognitive impairment and how this may contribute to medication burden.\"},{\"question\":\"Which dataset and time period were used to define cognitive impairment?\",\"answer\":\"NHANES 2011–2014 was selected because it contains objective cognitive measurements (Cognitive Functioning Assessment) for identifying impairment.\"},{\"question\":\"How was the relationship between supplement use and prescription medication use tested?\",\"answer\":\"Design-adjusted t-tests and Rao–Scott tests compared users vs. non-users, and negative binomial regression evaluated associations with the number of prescription medications while adjusting for covariates.\"}]","DIETARY SUPPLEMENT AND PRESCRIPTION MEDICATION USE AMONG OLDER ADULTS WITH COGNITIVE IMPAIRMENT - Research paper summary | PDF",1790644617]