[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-372171-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-372171-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","diameter-thresholds-for-pure-ground-glass-pulmonary-nodules-at-low-dose-ct-screening-chinese-experience","Diameter thresholds for pure ground-glass pulmonary nodules at low-dose CT screening: Chinese experience","","Limited research has examined diameter thresholds for detecting malignant pure ground-glass lung nodules (pGGNs) using low-dose CT screening in the Chinese population. A retrospective Guangzhou Lung-Care study retrieved average transverse diameter, location, histopathology, nodule frequency, and follow-up intervals. Diagnostic performance across 5–10 mm thresholds was assessed with AUC, decision curve analysis, sensitivity, and specificity. Malignancies were grouped into MIA+IA, AAH+AIS+MIA+IA, and IA-only. Results showed improved specificity and PPV up to 8 mm with acceptable sensitivity trade-offs, and decision curve analysis supported the 8 mm model.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/diameter-thresholds-for-pure-ground-glass-pulmonary-nodules-at-low-dose-ct-screening-chinese-experience/372171/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/diameter-thresholds-for-pure-ground-glass-pulmonary-nodules-at-low-dose-ct-screening-chinese-experience/372171.png","ImageObject",300,407,{"name":42,"@type":43},"Oliver","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What population and study design were used to evaluate CT diameter thresholds for pGGNs?","Question",{"text":63,"@type":64},"A retrospective analysis of the Guangzhou Lung-Care programme was conducted, using retrieved nodule measurements, histopathology, frequency, and follow-up intervals to assess diagnostic performance.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How did changing the diameter threshold affect sensitivity and specificity?",{"text":68,"@type":64},"Increasing the threshold from 5 mm to 8 mm improved specificity and positive predictive value but reduced sensitivity. Raising further from 8 mm decreased sensitivity while slightly increasing specificity and PPV.",{"name":70,"@type":61,"acceptedAnswer":71},"Why is the 8 mm threshold considered more useful clinically in this study?",{"text":72,"@type":64},"Decision curve analysis indicated that the predictive model using an 8 mm threshold had greater clinical utility than models using other thresholds, while AUC patterns showed comparable category performance at 8 mm.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},372171,1790643423,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":55,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Lung cancer  \nOriginal research  \nDiameter thresholds for pure ground-glass pulmonary nodules at low-dose CT screening:  \nChinese experience  \nWenjun Ye  , 1,2 Wenhai Fu, 1 Caichen Li, 1 Jianfu Li, 1 Shan Xiong, 1 Bo Cheng, 1 Bin Xu,3 Qixia Wang,4 Yi Feng  , 1 Peiling Chen  , 1 Jianxing He  , 1 Wenhua Liang  1,2  \n► Additional supplemental material is published online only. To view, please visit the journal online ([https://doi](https://doi). org/10.1136/thorax-2024- 221642) .  \nFor numbered affiliations see end of article.  \nCorrespondence to  \nProfessor Jianxing He; drjianxing. he@gmail.com and Dr Wenhua Liang; [liangwh1987@163.com](liangwh1987@163.com)  \nWY, WF and CL contributed equally.  \nWY, WF and CL are joint first authors.  \nJH and WL are joint senior authors.  \nReceived 5 March 2024 Accepted 27 October 2024  \n© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.  \nTo cite: Ye W, Fu W, Li C, et al. Thorax Epub ahead of print: [please include Day Month Year] . doi:10 . 1136/ thorax-2024-221642  \nABSTRACT  \nBackground Limited research exists on screening thresholds for low-dose CT in detecting malignant pure ground-glass lung nodules (pGGNs) in the Chinese population.  \nMaterials and methods A retrospective analysis of the Guangzhou Lung-Care programme was conducted, retrieving average transverse diameter, location, histopathology, frequency and follow-up intervals. Diagnostic performances for ’lung cancers’were evaluated using areas under the curve (AUCs), decision curve analysis (DCA), sensitivities and specificities, with thresholds ranging from 5 mm to 10 mm. We divide malignant pGGNs into three groups:  \n(1) minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IA),(2) atypical adenomatous hyperplasia (AAH) and adenocarcinoma in situ (AIS) and MIA and IA and (3) IA-only.  \nResults In ’MIA+IA’, increasing the threshold from  \n5 mm to 8 mm improved specificity (60 .97% to 88.85%, p\u003C0 .001) and positive predictive values (PPVs; 5.87% to 14.88%, p\u003C0 .001), but decreased sensitivity (94 .44% to 75 . 56%, p\u003C0 .001) . Further raising threshold from 8 mm reduced sensitivity (75 . 56% to 60.00%, p\u003C0 .001), while slightly increasing specificity (88 .85% to 93 .47%, p\u003C0 .001) and PPVs (14 .88% to 19. 15%, p\u003C0 .001) . Increasing threshold from 5 mm to 7 mm enhanced the AUC for ’MIA+IA’ (from 0.711 to 0.829),’AAH+AIS+MIA+IA’ (from 0.748 to 0 .804) and’IA-only’(from 0.783 to 0 .833) . At 8 mm, the AUCs for these categories were similar. However, increasing the threshold from 7 mm to 10 mm resulted in reduced AUCs for ’MIA+IA’ (0 .829 to 0. 767),’AAH+AIS+MIA+IA’(0 .804 to 0 . 744) and ’IA-only’(0 .833 to 0 .800) . DCA reveals that the 8 mm predictive model demonstrates greater clinical utility compared with models with other thresholds.  \nConclusions Increasing the diameter threshold for positive results for pGGNs, up to 8 mm could enhance diagnostic performance.  \nTrial registration number NCT04938804 .  \nINTRODUCTION  \nThe advent of low-dose CT (LDCT) has significantly increased the detection of pure groundglass nodules (pGGNs) in regions like China.1–3 These pGGNs, which may be transient or evolve  \n\n| WHAT IS ALREADY KNOWN ON THIS TOPIC\u003Cbr>⇒ Prior studies, including the National Lung Screening Trial, the International Lung Screening Trial, the Early Lung Cancer Action Project (ELCAP), and extensions like New York-ELCAP and International-ELCAP, as well as the NELSON trial, have primarily focused on semi-solid and solid nodules. This research emphasis has led to a lack of specific early screening cohorts for pure ground-glass nodules, a gap this paper seeks to address by exploring diameter thresholds in low-dose CT (LDCT) screenings.\u003Cbr>WHAT THIS STUDY ADDS |\n| --- |\n| ⇒ Raising the diameter threshold for identifying malignant pure ground-glass nodules (pGGNs) from 5 mm to 8 mm LDCT scans improves diagnostic specificity and po","cbCain2ZObieTCJE","https://ap.wps.com/l/cbCain2ZObieTCJE","pdf",1811529,"English","# ABSTRACT\n# Background\n# Materials and methods\n## Thresholds and diagnostic evaluation\n# Results\n## Performance trends across thresholds\n# Conclusions\n# Trial registration","[{\"question\":\"What population and study design were used to evaluate CT diameter thresholds for pGGNs?\",\"answer\":\"A retrospective analysis of the Guangzhou Lung-Care programme was conducted, using retrieved nodule measurements, histopathology, frequency, and follow-up intervals to assess diagnostic performance.\"},{\"question\":\"How did changing the diameter threshold affect sensitivity and specificity?\",\"answer\":\"Increasing the threshold from 5 mm to 8 mm improved specificity and positive predictive value but reduced sensitivity. Raising further from 8 mm decreased sensitivity while slightly increasing specificity and PPV.\"},{\"question\":\"Why is the 8 mm threshold considered more useful clinically in this study?\",\"answer\":\"Decision curve analysis indicated that the predictive model using an 8 mm threshold had greater clinical utility than models using other thresholds, while AUC patterns showed comparable category performance at 8 mm.\"}]","Diameter thresholds for pure ground-glass pulmonary nodules at low-dose CT screening: Chinese experience | PDF",1790193882,25]