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A prospective single-blind randomized trial enrolled 240 patients confirmed by CT/MRI, assigning equal groups to B-EUS, EG-EUS, CE-EUS, and SSC-EUS with ROC-based diagnostic thresholds. SSC-EUS showed optimal performance at 1,563 m/s with sensitivity 82.8% and specificity 78.9%. CE-EUS achieved the highest overall efficacy and subgroup results supported lesion-specific advantages, while EG-EUS strain measures showed limited accuracy.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/diagnostic-value-of-sound-speed-correction-endoscopic-ultrasound-compared-with-other-endoscopic-ultrasound-assisted-imaging-techniques-in-solid-pancreatic-lesions-article-1/353541/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/diagnostic-value-of-sound-speed-correction-endoscopic-ultrasound-compared-with-other-endoscopic-ultrasound-assisted-imaging-techniques-in-solid-pancreatic-lesions-article-1/353541.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is SSC-EUS and what diagnostic problem does it target?","Question",{"text":113,"@type":114},"SSC-EUS is a sound speed correction endoscopic ultrasound technique proposed for improved imaging. It targets the diagnostic evaluation of solid pancreatic lesions.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the diagnostic performance of SSC-EUS compared in the study?",{"text":118,"@type":114},"A prospective single-blind randomized trial assigned 240 patients to four imaging groups: B-EUS, EG-EUS, CE-EUS, and SSC-EUS. Diagnostic thresholds were set using receiver operating characteristic curves.",{"name":120,"@type":111,"acceptedAnswer":121},"Which imaging modality showed the best overall diagnostic efficacy?",{"text":122,"@type":114},"CE-EUS demonstrated the highest overall efficacy, with SSC-EUS and EG-EUS performing next, while B-EUS showed lower accuracy.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},353541,1790657985,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","ARTICLE 1  \nINTRODUCTION: Sound speed correction endoscopic ultrasound (SSC-EUS) is a novel imaging technique with limited previous validation. The aim of this study was to evaluate the diagnostic efficacy of SSC-EUS for solid pancreatic lesions (SPL) and compare it with B-mode endoscopic ultrasound (B-EUS), elastographyendoscopic ultrasound (EG-EUS), and contrast-enhanced endoscopic ultrasound (CE-EUS) .  \nMETHODS: A prospective, single-blind, randomized trial included 240 patients with computed tomography/ magnetic resonance imaging-confirmed SPL (solid portion >80% of lesion volume) . Participants were equally divided into 4 groups (B-EUS, EG-EUS, CE-EUS, and SSC-EUS) . Diagnostic thresholds were determined through receiver operating characteristic curves. Subgroup analyses assessed the impact of lesion location (head/body/tail), tumor size (£3 vs >3 cm), and cancer stage (I/II vs III/IV) . Statistical analysis used SPSS 23.0 and GraphPad Prism 8.  \nRESULTS: Among 240 patients, 138 (57.5%) had malignant lesions. SSC-EUS achieved optimal diagnostic performance at a cutoff sound speed of 1,563 m/s (area under the receiver operating characteristic curve 5 0.822, sensitivity 5 82.8%, specificity 5 78.9%, accuracy 5 81.7%) . CE-EUS demonstrated the highest overall efficacy (sensitivity 5 90.3%, specificity 5 82.8%, accuracy 5  \n86.7%), followed by SSC-EUS and EG-EUS, both outperforming B-EUS (accuracy 5 70.0%) . Subgroup analysis revealed superior sensitivity for pancreatic body lesions (SSC-EUS: 87.5%; CEEUS: 90.0%), tumors >3 cm (SSC-EUS: 84.2%; CE-EUS: 90.0%), and stage III/IV cancers (SSCEUS: 81.8%; CE-EUS: 90.9%) . EG-EUS strain ratio (cutoff 5 4.44) showed limited accuracy (61.7%), whereas elastic strain value A (cutoff 5 0.065%) exhibited moderate utility (accuracy 5  \n75.0%) .  \nDISCUSSION: CE-EUS remains the most effective imaging modality for SPL diagnosis. SSC-EUS demonstrates comparable accuracy with EG-EUS and is particularly advantageous for larger tumors (>3 cm) and advanced-stage malignancies. EG-EUS strain ratio lacks clinical robustness, whereas elastic strain value A warrants further validation. Tailoring imaging method selection to lesion characteristics (location, size, and stage) may optimize diagnostic outcomes.  \nKEYWORDS: endoscopic ultrasound; assisted imaging; pancreatic cancer; sound speed correction; diagnostic efficacy  \nABBREVIATIONS: AUROC, area under the receiver operator characteristic curve; B-EUS, B-mode endoscopic ultrasound; CE-EUS, contrast-enhanced endoscopic ultrasound; CP, chronic pancreatitis; CT, computer tomography; EG-EUS, elastography endoscopic ultrasound; EUS, endoscopic ultrasound; EUS-FNA, endoscopic ultrasound-guided fine-needle aspiration; NET, neuroendocrine tumor; NPV, negative predictive value; PC, pancreatic cancer; PDAC, pancreatic ductal adenocarcinoma; PPV, positive predictive value; ROC,  \nDiagnostic Value of Sound Speed Correction Endoscopic Ultrasound Compared With Other Endoscopic Ultrasound-Assisted Imaging Techniques in Solid Pancreatic Lesions  \nDun-Wei Yao, PhD1 ,3 , *, Yi-Han Lu, MM 1 ,3 , *, Hai-Xing Jiang, PhD2 , Min-Zhen Qin, PhD1 ,3 and Shan-Yu Qin, PhD2  \nENDOSCOPY  \n1Department of Gastroenterology, Baise People’s Hospital, Baise City, Guangxi Zhuang Autonomous Region, China; 2Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; 3Affiliated Southwest Hospital of Youjiang Medical University for Nationalities, Baise  \nCity, Guangxi, China. Correspondence: Min-Zhen Qin, PhD. E-mail: [qinminzhen@126.com. Shan-Yu Qin](qinminzhen@126.com. Shan-Yu Qin), PhD. E-mail: [qinshanyu@gxmu.edu.cn](qinshanyu@gxmu.edu.cn).  \n*Dun-Wei Yao and Yi-Han Lu contributed equally to this article.  \nReceived May 21, 2025; accepted October 9, 2025; published online November 10, 2025  \n© 2025 The Author(s) . Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology  \nAmerican College ","cbCaiez8LYd4xRgZ","https://ap.wps.com/l/cbCaiez8LYd4xRgZ","pdf",1168373,"English","# Introduction\n# Methods\n# Results\n# Discussion","[{\"question\":\"What is SSC-EUS and what diagnostic problem does it target?\",\"answer\":\"SSC-EUS is a sound speed correction endoscopic ultrasound technique proposed for improved imaging. It targets the diagnostic evaluation of solid pancreatic lesions.\"},{\"question\":\"How was the diagnostic performance of SSC-EUS compared in the study?\",\"answer\":\"A prospective single-blind randomized trial assigned 240 patients to four imaging groups: B-EUS, EG-EUS, CE-EUS, and SSC-EUS. Diagnostic thresholds were set using receiver operating characteristic curves.\"},{\"question\":\"Which imaging modality showed the best overall diagnostic efficacy?\",\"answer\":\"CE-EUS demonstrated the highest overall efficacy, with SSC-EUS and EG-EUS performing next, while B-EUS showed lower accuracy.\"}]","Diagnostic Value of Sound Speed Correction Endoscopic Ultrasound Compared With Other Endoscopic Ultrasound-Assisted Imaging Techniques in Solid Pancreatic Lesions - Article 1 | PDF",1790105970,28]