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This prospective case-controlled study assessed whether plasma osteopontin (OPN) improves diagnosis of HCV-related HCC compared with alpha-fetoprotein (AFP). The study included 113 HCC patients versus 120 matched cirrhotic patients and 120 controls. Plasma OPN was significantly higher in HCC and showed superior diagnostic efficacy to AFP by AUC, sensitivity, specificity, PPV, and NPV across early and late stages. OPN also demonstrated prognostic relevance beyond AFP.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/diagnostic-significance-of-plasma-osteopontin-in-hepatitis-c-virus-related-hepatocellular-carcinoma/508326/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/diagnostic-significance-of-plasma-osteopontin-in-hepatitis-c-virus-related-hepatocellular-carcinoma/508326.png","ImageObject",300,407,{"name":92,"@type":93},"Franzy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-10-05",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main diagnostic goal of the study?","Question",{"text":112,"@type":113},"To determine the diagnostic value of plasma osteopontin (OPN) for HCV-related hepatocellular carcinoma and compare it with alpha-fetoprotein (AFP).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were study groups defined?",{"text":117,"@type":113},"The study recruited 113 HCC patients and compared them with 120 matched cirrhotic patients and 120 controls.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key findings regarding OPN versus AFP?",{"text":121,"@type":113},"Plasma OPN levels were significantly higher in HCC than in cirrhotic patients and controls, and OPN showed superior diagnostic efficacy to AFP in AUC, sensitivity, specificity, PPV, and NPV for both early and late HCC stages.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},508326,1791292357,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},2336478945519,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","ORIGINAL ARTICLE  \nJuly-September, Vol. 10 No.3, 2011: 296-305  \nDiagnostic significance of plasma osteopontin in hepatitis C virus-related hepatocellular carcinoma  \nMona A. Abu El Makarem,* Ashraf Abdel-Aleem,* Ahmed Ali,*  \nRafet Saber,** Mohammed Shatat,* Doaa Abdel Rahem,* Douaa Sayed***  \n* Department of Internal Medicine, Medical School, Minia University, Egypt. ** Department of Oncology, Medical School, Minia University, Egypt.  \n*** Flow Cytometry Lab, Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Egypt.  \nABSTRACT  \nBackground and aim: Outcome of hepatocellular carcinoma (HCC) depends mainly on its early diagnosis. The performance of traditional biomarkers is not satisfactory. Osteopontin (OPN) is of potential importance. This study aim to assess the diagnostic value of plasma OPN compared with alpha-fetoprotein (AFP) for the diagnosis of HCV- related HCC. Methods: We recruited 113 HCC patients compared with 120 matched cirrhotic patients and 120 Controls. The plasma level of OPN and serum AFP for all participants were assessed. Results: The median plasma OPN level was significantly higher in the HCC group than in the cirrhotic patient group or in the normal control group (p-value \u003C 0.001), while OPN levels were not differed significantly in correlation with the degree of liver function deterioration in terms of advanced Child-Pugh class (p-value \u003C 0.9) . The diagnostic efficacy of OPN were superior to AFP in terms of AUC, sensitivity, specificity, PPV and NPV either in diagnosis of early or late stages of HCC (0.88 vs. 0.56; P = 0.0001, 0.991vs. 0.899; p = 0.01; respectively) . Conclusion: Plasma OPN level is a potential diagnostic marker for HCC, especially among high-risk group of patients. These values extend beyond the traditional tumor biomarkers as AFP, as it possesses good prognostic value.  \nKey words. Osteopontin. Hepatitis C virus infection. Hepatocellular carcinoma. Diagnosis. Prognosis.  \nINTRODUCTION  \nHepatocellular carcinoma (HCC) is the fifth most common tumor and the third most common cause of cancer-related deaths worldwide. 1,2 HCC incidence has increased sharply over recent decades and this has been partially attributed to chronic HCV infection.3-6 In Egypt, the growing incidence of HCC, which is nearly doubled over the last decade7-10 is parallel with that Egypt are plugged with highest prevalence of HCV in the world, ranging from 6 to 28% .11-13 The prevelance of serological markers of HCV infection in patients with HCC is nearly 80% .14  \nCorrespondence and reprint request: Prof. Mona Abu El Makarem Professor of Internal Medicine, Medical School; Minia University, Minia 61111, Egypt.  \nTel.: +20862366553. Fax: +2086242813  \n[E-mail: mona.makarem@yahoo.com](E-mail: mona.makarem@yahoo.com)  \nManuscript received: March 14, 2011.  \nManuscript accepted: April 08, 2011.  \nHCC represents the leading cause of death from all other cancer sites.10  \nThe incidence and mortality rates for HCC are virtually identical, reflecting the overall poor survival of patients with this tumor. Most effective therapies exist for HCC if diagnosed early.15  \nCurrently, D-fetoprotein (AFP) is the most validated serological marker for HCC. Even though AFP’s performance in early stage HCC are deficient, 16 the sensitivity and specificity of plasma AFP detection ( > 20 ng/mL) in screening tests were set at about 50% and 85%, respectively.17 According to the new update of the American Association for the Study of Liver Diseases (AASLD) practice guideline for HCC, AFP alone should not be used for HCC screening unless ultrasound isnot available.15 Recent systematic reviews of the literature show that the quality of evidence supporting the use of AFP as a diagnostic and screening test for HCV-related HCC is limited. 18,19 In addition; this is traditional biomarkers don’t reflect  \n© 2019, Fundación Clínica Médica Sur, A.C. Published by Elsevier España S.L.U. This is an open access article under","cbCaisLJiEj3w0Xd","https://ap.wps.com/l/cbCaisLJiEj3w0Xd","pdf",205886,"English","# Abstract\n# Introduction\n# Patient and Methods","[{\"question\":\"What was the main diagnostic goal of the study?\",\"answer\":\"To determine the diagnostic value of plasma osteopontin (OPN) for HCV-related hepatocellular carcinoma and compare it with alpha-fetoprotein (AFP).\"},{\"question\":\"How were study groups defined?\",\"answer\":\"The study recruited 113 HCC patients and compared them with 120 matched cirrhotic patients and 120 controls.\"},{\"question\":\"What were the key findings regarding OPN versus AFP?\",\"answer\":\"Plasma OPN levels were significantly higher in HCC than in cirrhotic patients and controls, and OPN showed superior diagnostic efficacy to AFP in AUC, sensitivity, specificity, PPV, and NPV for both early and late HCC stages.\"}]","Diagnostic significance of plasma osteopontin in hepatitis C virus-related hepatocellular carcinoma | PDF",1791217410,25]